Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application
In this work, TiMg metal-metal composites (MMCs) were successfully fabricated by spark plasma sintering (SPS). In vitro, the proliferation and differentiation of SaOS-2 cells in response to TiMg metal-metal composites (MMCs) were investigated. In vivo, a rat model with femur condyle defect was emp...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2019-12-01
|
| Series: | Bioactive Materials |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X18300707 |
| _version_ | 1797203926233120768 |
|---|---|
| author | Sihui Ouyang Qianli Huang Yong Liu Zhengxiao Ouyang Luxin Liang |
| author_facet | Sihui Ouyang Qianli Huang Yong Liu Zhengxiao Ouyang Luxin Liang |
| author_sort | Sihui Ouyang |
| collection | DOAJ |
| description | In this work, TiMg metal-metal composites (MMCs) were successfully fabricated by spark plasma sintering (SPS). In vitro, the proliferation and differentiation of SaOS-2 cells in response to TiMg metal-metal composites (MMCs) were investigated. In vivo, a rat model with femur condyle defect was employed, and TiMg MMCs implants were embedded into the femur condyles. Results showed that TiMg MMCs exhibited enhanced cytocompatibility to SaOS-2 cells than pure Ti. The micro-computed tomography (Micro-CT) results showed that the volume of bone trabecula was significantly more abundant around TiMg implants than around Ti implants, indicating that more active new-bone formed around TiMg MMCs implants. Hematoxylin-eosin (H&E) staining analysis revealed significantly greater osteointegration around TiMg implants than that around Ti implants. Keywords: Powder metallurgy, Composites, Osteoconduction, Osseointegration |
| first_indexed | 2024-04-24T08:27:05Z |
| format | Article |
| id | doaj.art-92e4a018c41e4a649389ef9b8d7460e7 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:27:05Z |
| publishDate | 2019-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-92e4a018c41e4a649389ef9b8d7460e72024-04-16T22:06:32ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2019-12-0143742Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic applicationSihui Ouyang0Qianli Huang1Yong Liu2Zhengxiao Ouyang3Luxin Liang4State Key Lab of Powder Metallurgy, Central South University, Changsha, 410083, PR ChinaState Key Lab of Powder Metallurgy, Central South University, Changsha, 410083, PR China; Corresponding author.State Key Lab of Powder Metallurgy, Central South University, Changsha, 410083, PR China; Corresponding author.Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, PR ChinaState Key Lab of Powder Metallurgy, Central South University, Changsha, 410083, PR ChinaIn this work, TiMg metal-metal composites (MMCs) were successfully fabricated by spark plasma sintering (SPS). In vitro, the proliferation and differentiation of SaOS-2 cells in response to TiMg metal-metal composites (MMCs) were investigated. In vivo, a rat model with femur condyle defect was employed, and TiMg MMCs implants were embedded into the femur condyles. Results showed that TiMg MMCs exhibited enhanced cytocompatibility to SaOS-2 cells than pure Ti. The micro-computed tomography (Micro-CT) results showed that the volume of bone trabecula was significantly more abundant around TiMg implants than around Ti implants, indicating that more active new-bone formed around TiMg MMCs implants. Hematoxylin-eosin (H&E) staining analysis revealed significantly greater osteointegration around TiMg implants than that around Ti implants. Keywords: Powder metallurgy, Composites, Osteoconduction, Osseointegrationhttp://www.sciencedirect.com/science/article/pii/S2452199X18300707 |
| spellingShingle | Sihui Ouyang Qianli Huang Yong Liu Zhengxiao Ouyang Luxin Liang Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application Bioactive Materials |
| title | Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application |
| title_full | Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application |
| title_fullStr | Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application |
| title_full_unstemmed | Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application |
| title_short | Powder metallurgical Ti-Mg metal-metal composites facilitate osteoconduction and osseointegration for orthopedic application |
| title_sort | powder metallurgical ti mg metal metal composites facilitate osteoconduction and osseointegration for orthopedic application |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X18300707 |
| work_keys_str_mv | AT sihuiouyang powdermetallurgicaltimgmetalmetalcompositesfacilitateosteoconductionandosseointegrationfororthopedicapplication AT qianlihuang powdermetallurgicaltimgmetalmetalcompositesfacilitateosteoconductionandosseointegrationfororthopedicapplication AT yongliu powdermetallurgicaltimgmetalmetalcompositesfacilitateosteoconductionandosseointegrationfororthopedicapplication AT zhengxiaoouyang powdermetallurgicaltimgmetalmetalcompositesfacilitateosteoconductionandosseointegrationfororthopedicapplication AT luxinliang powdermetallurgicaltimgmetalmetalcompositesfacilitateosteoconductionandosseointegrationfororthopedicapplication |