Endothelial MICU1 alleviates diabetic cardiomyopathy by attenuating nitrative stress-mediated cardiac microvascular injury

Endothelial MICU1 alleviates diabetic cardiomyopathy by attenuating nitrative stress-mediated cardiac microvascular injury

Abstract Background Myocardial microvascular injury is the key event in early diabetic heart disease. The injury of myocardial microvascular endothelial cells (CMECs) is the main cause and trigger of myocardial microvascular disease. Mitochondrial calcium homeostasis plays an important role in maint...

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Bibliographic Details
Main Authors: Xide Shi, Chao Liu, Jiangwei Chen, Shiqiang Zhou, Yajuan Li, Xingcheng Zhao, Jinliang Xing, Junhui Xue, Fengzhou Liu, Fei Li
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Cardiovascular Diabetology
Subjects:
MICU1
Diabetic cardiomyopathy
Cardiac microvascular endothelial cells (CMECs)
Nitrative stress
Inflammatory response
Endothelial permeability
Online Access:https://doi.org/10.1186/s12933-023-01941-1

Internet

https://doi.org/10.1186/s12933-023-01941-1

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