| Summary: | Interferon-alpha-16 (IFNA16) and tumor necrosis factor receptor superfamily member 19 (TNFRSF19) are cytokines that may play a role in adipogenesis and fatness. Single nucleotide polymorphisms (SNPs) of the porcine <i>IFNA16</i> and <i>TNFRSF19</i> genes were verified and their association with intramuscular fat (IMF) content and fatty acid (FA) composition were evaluated in commercial crossbred pigs. Two non-synonymous SNPs of the porcine <i>IFNA16</i> c.413G > A and <i>TNFRSF19</i> c.860G > C loci were detected in commercial crossbred pigs. The porcine <i>IFNA16</i> c.413G >A polymorphism was significantly associated with stearic acid, total saturated FAs (SFAs), and the ratio of monounsaturated FAs (MUFAs) to SFAs (<i>p</i> < 0.05). Furthermore, the porcine <i>TNFRSF19</i> c.860G > C polymorphism was found to be significantly associated with IMF content and arachidic acid levels (<i>p</i> < 0.05). The results revealed that porcine <i>IFNA16</i> and <i>TNFRSF19</i> polymorphisms are related to IMF content and/or FA composition and affirmed the importance of these cytokine genes as potential candidate genes for lipid deposition and FA composition in the muscle tissue of pigs.
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