Association of <i>IFNA16</i> and <i>TNFRSF19</i> Polymorphisms with Intramuscular Fat Content and Fatty Acid Composition in Pigs
Interferon-alpha-16 (IFNA16) and tumor necrosis factor receptor superfamily member 19 (TNFRSF19) are cytokines that may play a role in adipogenesis and fatness. Single nucleotide polymorphisms (SNPs) of the porcine <i>IFNA16</i> and <i>TNFRSF19</i> genes were verified and the...
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MDPI AG
2022-01-01
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| author | Supamit Mekchay Nanthana Pothakam Worrarak Norseeda Pantaporn Supakankul Tawatchai Teltathum Guisheng Liu Watcharapong Naraballobh Trisadee Khamlor Korawan Sringarm Patcharin Krutmuang |
| author_facet | Supamit Mekchay Nanthana Pothakam Worrarak Norseeda Pantaporn Supakankul Tawatchai Teltathum Guisheng Liu Watcharapong Naraballobh Trisadee Khamlor Korawan Sringarm Patcharin Krutmuang |
| author_sort | Supamit Mekchay |
| collection | DOAJ |
| description | Interferon-alpha-16 (IFNA16) and tumor necrosis factor receptor superfamily member 19 (TNFRSF19) are cytokines that may play a role in adipogenesis and fatness. Single nucleotide polymorphisms (SNPs) of the porcine <i>IFNA16</i> and <i>TNFRSF19</i> genes were verified and their association with intramuscular fat (IMF) content and fatty acid (FA) composition were evaluated in commercial crossbred pigs. Two non-synonymous SNPs of the porcine <i>IFNA16</i> c.413G > A and <i>TNFRSF19</i> c.860G > C loci were detected in commercial crossbred pigs. The porcine <i>IFNA16</i> c.413G >A polymorphism was significantly associated with stearic acid, total saturated FAs (SFAs), and the ratio of monounsaturated FAs (MUFAs) to SFAs (<i>p</i> < 0.05). Furthermore, the porcine <i>TNFRSF19</i> c.860G > C polymorphism was found to be significantly associated with IMF content and arachidic acid levels (<i>p</i> < 0.05). The results revealed that porcine <i>IFNA16</i> and <i>TNFRSF19</i> polymorphisms are related to IMF content and/or FA composition and affirmed the importance of these cytokine genes as potential candidate genes for lipid deposition and FA composition in the muscle tissue of pigs. |
| first_indexed | 2024-03-10T01:53:06Z |
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| id | doaj.art-92e8514d025546c9a1eae9b2f4c0f633 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T01:53:06Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-92e8514d025546c9a1eae9b2f4c0f6332023-11-23T13:01:22ZengMDPI AGBiology2079-77372022-01-0111110910.3390/biology11010109Association of <i>IFNA16</i> and <i>TNFRSF19</i> Polymorphisms with Intramuscular Fat Content and Fatty Acid Composition in PigsSupamit Mekchay0Nanthana Pothakam1Worrarak Norseeda2Pantaporn Supakankul3Tawatchai Teltathum4Guisheng Liu5Watcharapong Naraballobh6Trisadee Khamlor7Korawan Sringarm8Patcharin Krutmuang9Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Agriculture, Faculty of Agricultural Technology, Lampang Rajabhat University, Lampang 52100, ThailandDivision of Animal Science, School of Agriculture and Natural Resources, University of Phayao, Phayao 56000, ThailandMae Hong Son Livestock Research and Breeding Center, Mae Hong Son 58000, ThailandInstitute of Animal Science and Veterinary Medicine, Hubei Academy of Agricultural Sciences, Wuhan 430064, ChinaDepartment of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, ThailandInnovative Agriculture Research Center, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, ThailandInterferon-alpha-16 (IFNA16) and tumor necrosis factor receptor superfamily member 19 (TNFRSF19) are cytokines that may play a role in adipogenesis and fatness. Single nucleotide polymorphisms (SNPs) of the porcine <i>IFNA16</i> and <i>TNFRSF19</i> genes were verified and their association with intramuscular fat (IMF) content and fatty acid (FA) composition were evaluated in commercial crossbred pigs. Two non-synonymous SNPs of the porcine <i>IFNA16</i> c.413G > A and <i>TNFRSF19</i> c.860G > C loci were detected in commercial crossbred pigs. The porcine <i>IFNA16</i> c.413G >A polymorphism was significantly associated with stearic acid, total saturated FAs (SFAs), and the ratio of monounsaturated FAs (MUFAs) to SFAs (<i>p</i> < 0.05). Furthermore, the porcine <i>TNFRSF19</i> c.860G > C polymorphism was found to be significantly associated with IMF content and arachidic acid levels (<i>p</i> < 0.05). The results revealed that porcine <i>IFNA16</i> and <i>TNFRSF19</i> polymorphisms are related to IMF content and/or FA composition and affirmed the importance of these cytokine genes as potential candidate genes for lipid deposition and FA composition in the muscle tissue of pigs.https://www.mdpi.com/2079-7737/11/1/109fatty acid<i>IFNA16</i>intramuscular fatMUFAporkSFA |
| spellingShingle | Supamit Mekchay Nanthana Pothakam Worrarak Norseeda Pantaporn Supakankul Tawatchai Teltathum Guisheng Liu Watcharapong Naraballobh Trisadee Khamlor Korawan Sringarm Patcharin Krutmuang Association of <i>IFNA16</i> and <i>TNFRSF19</i> Polymorphisms with Intramuscular Fat Content and Fatty Acid Composition in Pigs Biology fatty acid <i>IFNA16</i> intramuscular fat MUFA pork SFA |
| title | Association of <i>IFNA16</i> and <i>TNFRSF19</i> Polymorphisms with Intramuscular Fat Content and Fatty Acid Composition in Pigs |
| title_full | Association of <i>IFNA16</i> and <i>TNFRSF19</i> Polymorphisms with Intramuscular Fat Content and Fatty Acid Composition in Pigs |
| title_fullStr | Association of <i>IFNA16</i> and <i>TNFRSF19</i> Polymorphisms with Intramuscular Fat Content and Fatty Acid Composition in Pigs |
| title_full_unstemmed | Association of <i>IFNA16</i> and <i>TNFRSF19</i> Polymorphisms with Intramuscular Fat Content and Fatty Acid Composition in Pigs |
| title_short | Association of <i>IFNA16</i> and <i>TNFRSF19</i> Polymorphisms with Intramuscular Fat Content and Fatty Acid Composition in Pigs |
| title_sort | association of i ifna16 i and i tnfrsf19 i polymorphisms with intramuscular fat content and fatty acid composition in pigs |
| topic | fatty acid <i>IFNA16</i> intramuscular fat MUFA pork SFA |
| url | https://www.mdpi.com/2079-7737/11/1/109 |
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