Proteinuria and Electrophoretic Pattern in Dogs with Comorbidities Associated with Chronic Kidney Disease
In animals with chronic pathologies, the detection of proteinuria via the proteinuria: creatininuria ratio (UPC) and urinary protein electrophoresis allows for the early diagnosis of chronic kidney disease (CKD). The objective of this work was to identify and determine the magnitude of proteinuria a...
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MDPI AG
2023-04-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/8/1399 |
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| author | Alicia Pamela Pérez-Sánchez Sofía Perini-Perera Javier Del-Angel-Caraza Israel Alejandro Quijano-Hernández Sergio Recillas-Morales |
| author_facet | Alicia Pamela Pérez-Sánchez Sofía Perini-Perera Javier Del-Angel-Caraza Israel Alejandro Quijano-Hernández Sergio Recillas-Morales |
| author_sort | Alicia Pamela Pérez-Sánchez |
| collection | DOAJ |
| description | In animals with chronic pathologies, the detection of proteinuria via the proteinuria: creatininuria ratio (UPC) and urinary protein electrophoresis allows for the early diagnosis of chronic kidney disease (CKD). The objective of this work was to identify and determine the magnitude of proteinuria and its electrophoretic pattern characterization in dogs with chronic diseases pathophysiologically related to proteinuria. With the studied patients, five groups were formed. The control group (CG) contained non-proteinuric cases. The cases with proteinuria were classified into four groups according to the concurrent disease: chronic inflammatory diseases (IG), neoplasms (NG), heart diseases (HG), and endocrine diseases (EG). For the statistical analysis, descriptive statistics and non-parametric tests were used. Data from 264 dogs were obtained; in the disease groups, proteinuria was observed in more than 30% as the only finding of kidney disease, evidencing a greater risk factor for proteinuria in the HG group (OR 4.047, CI 1.894–8.644, <i>p</i> < 0.0001). In the HG, NG, and EG groups, a higher frequency of glomerular pattern (GEP) related to glomerular hypertension was observed; in the IG, a higher frequency of mixed pattern (MEP) was observed. These findings are secondary to the hyperfiltration process that affects the glomerulus and the renal tubule. |
| first_indexed | 2024-03-11T05:19:07Z |
| format | Article |
| id | doaj.art-92e998fb327746fb8c4361d0c5f67346 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-11T05:19:07Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-92e998fb327746fb8c4361d0c5f673462023-11-17T18:01:16ZengMDPI AGAnimals2076-26152023-04-01138139910.3390/ani13081399Proteinuria and Electrophoretic Pattern in Dogs with Comorbidities Associated with Chronic Kidney DiseaseAlicia Pamela Pérez-Sánchez0Sofía Perini-Perera1Javier Del-Angel-Caraza2Israel Alejandro Quijano-Hernández3Sergio Recillas-Morales4Hospital Veterinario para Pequeñas Especies de la Facultad de Medicina Veterinaria y Zootecnia-Universidad Autonoma del Estado de México, Toluca 50130, MexicoHospital Veterinario para Pequeñas Especies de la Facultad de Medicina Veterinaria y Zootecnia-Universidad Autonoma del Estado de México, Toluca 50130, MexicoHospital Veterinario para Pequeñas Especies de la Facultad de Medicina Veterinaria y Zootecnia-Universidad Autonoma del Estado de México, Toluca 50130, MexicoHospital Veterinario para Pequeñas Especies de la Facultad de Medicina Veterinaria y Zootecnia-Universidad Autonoma del Estado de México, Toluca 50130, MexicoHospital Veterinario para Pequeñas Especies de la Facultad de Medicina Veterinaria y Zootecnia-Universidad Autonoma del Estado de México, Toluca 50130, MexicoIn animals with chronic pathologies, the detection of proteinuria via the proteinuria: creatininuria ratio (UPC) and urinary protein electrophoresis allows for the early diagnosis of chronic kidney disease (CKD). The objective of this work was to identify and determine the magnitude of proteinuria and its electrophoretic pattern characterization in dogs with chronic diseases pathophysiologically related to proteinuria. With the studied patients, five groups were formed. The control group (CG) contained non-proteinuric cases. The cases with proteinuria were classified into four groups according to the concurrent disease: chronic inflammatory diseases (IG), neoplasms (NG), heart diseases (HG), and endocrine diseases (EG). For the statistical analysis, descriptive statistics and non-parametric tests were used. Data from 264 dogs were obtained; in the disease groups, proteinuria was observed in more than 30% as the only finding of kidney disease, evidencing a greater risk factor for proteinuria in the HG group (OR 4.047, CI 1.894–8.644, <i>p</i> < 0.0001). In the HG, NG, and EG groups, a higher frequency of glomerular pattern (GEP) related to glomerular hypertension was observed; in the IG, a higher frequency of mixed pattern (MEP) was observed. These findings are secondary to the hyperfiltration process that affects the glomerulus and the renal tubule.https://www.mdpi.com/2076-2615/13/8/1399proteinuria: creatininuria ratiochronic kidney diseaseSDS PAGErenal biomarkerdogs |
| spellingShingle | Alicia Pamela Pérez-Sánchez Sofía Perini-Perera Javier Del-Angel-Caraza Israel Alejandro Quijano-Hernández Sergio Recillas-Morales Proteinuria and Electrophoretic Pattern in Dogs with Comorbidities Associated with Chronic Kidney Disease Animals proteinuria: creatininuria ratio chronic kidney disease SDS PAGE renal biomarker dogs |
| title | Proteinuria and Electrophoretic Pattern in Dogs with Comorbidities Associated with Chronic Kidney Disease |
| title_full | Proteinuria and Electrophoretic Pattern in Dogs with Comorbidities Associated with Chronic Kidney Disease |
| title_fullStr | Proteinuria and Electrophoretic Pattern in Dogs with Comorbidities Associated with Chronic Kidney Disease |
| title_full_unstemmed | Proteinuria and Electrophoretic Pattern in Dogs with Comorbidities Associated with Chronic Kidney Disease |
| title_short | Proteinuria and Electrophoretic Pattern in Dogs with Comorbidities Associated with Chronic Kidney Disease |
| title_sort | proteinuria and electrophoretic pattern in dogs with comorbidities associated with chronic kidney disease |
| topic | proteinuria: creatininuria ratio chronic kidney disease SDS PAGE renal biomarker dogs |
| url | https://www.mdpi.com/2076-2615/13/8/1399 |
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