Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation.

Single-molecule dynamics and genome-wide transcriptomics reveal that NF-kB (p65)-DNA binding times can be decoupled from transcriptional activation.

Transcription factors (TFs) regulate gene expression in both prokaryotes and eukaryotes by recognizing and binding to specific DNA promoter sequences. In higher eukaryotes, it remains unclear how the duration of TF binding to DNA relates to downstream transcriptional output. Here, we address this qu...

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Bibliographic Details
Main Authors: Andrea Callegari, Christian Sieben, Alexander Benke, David M Suter, Beat Fierz, Davide Mazza, Suliana Manley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007891

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