Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
Innate immunity sensors are expressed by both tumour cells and tumour-associated myeloid cells. Here, the authors show that stimulation of the innate immunity response with pseudoviruses in a genetic mouse model of intestinal cancer triggers tumour regression via Caspase-1 activation.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15004 |
| _version_ | 1818990639592767488 |
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| author | Zhenyu Zhong Yougang Zhai Ping Bu Shivanee Shah Liang Qiao |
| author_facet | Zhenyu Zhong Yougang Zhai Ping Bu Shivanee Shah Liang Qiao |
| author_sort | Zhenyu Zhong |
| collection | DOAJ |
| description | Innate immunity sensors are expressed by both tumour cells and tumour-associated myeloid cells. Here, the authors show that stimulation of the innate immunity response with pseudoviruses in a genetic mouse model of intestinal cancer triggers tumour regression via Caspase-1 activation. |
| first_indexed | 2024-12-20T19:57:34Z |
| format | Article |
| id | doaj.art-92ec82368ef3485b8daed75d8490090d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T19:57:34Z |
| publishDate | 2017-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-92ec82368ef3485b8daed75d8490090d2022-12-21T19:28:07ZengNature PortfolioNature Communications2041-17232017-04-018111210.1038/ncomms15004Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ miceZhenyu Zhong0Yougang Zhai1Ping Bu2Shivanee Shah3Liang Qiao4Department of Microbiology and Immunology, Health Sciences Division, Stritch School of Medicine, Loyola University ChicagoDepartment of Microbiology and Immunology, Health Sciences Division, Stritch School of Medicine, Loyola University ChicagoDepartment of Ophthalmology, Health Sciences Division, Stritch School of Medicine, Loyola University ChicagoDepartment of Microbiology and Immunology, Health Sciences Division, Stritch School of Medicine, Loyola University ChicagoDepartment of Microbiology and Immunology, Health Sciences Division, Stritch School of Medicine, Loyola University ChicagoInnate immunity sensors are expressed by both tumour cells and tumour-associated myeloid cells. Here, the authors show that stimulation of the innate immunity response with pseudoviruses in a genetic mouse model of intestinal cancer triggers tumour regression via Caspase-1 activation.https://doi.org/10.1038/ncomms15004 |
| spellingShingle | Zhenyu Zhong Yougang Zhai Ping Bu Shivanee Shah Liang Qiao Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice Nature Communications |
| title | Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice |
| title_full | Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice |
| title_fullStr | Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice |
| title_full_unstemmed | Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice |
| title_short | Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice |
| title_sort | papilloma pseudovirus eradicates intestinal tumours and triples the lifespan of apcmin mice |
| url | https://doi.org/10.1038/ncomms15004 |
| work_keys_str_mv | AT zhenyuzhong papillomapseudoviruseradicatesintestinaltumoursandtriplesthelifespanofapcminmice AT yougangzhai papillomapseudoviruseradicatesintestinaltumoursandtriplesthelifespanofapcminmice AT pingbu papillomapseudoviruseradicatesintestinaltumoursandtriplesthelifespanofapcminmice AT shivaneeshah papillomapseudoviruseradicatesintestinaltumoursandtriplesthelifespanofapcminmice AT liangqiao papillomapseudoviruseradicatesintestinaltumoursandtriplesthelifespanofapcminmice |