Building blocks of microphysiological system to model physiology and pathophysiology of human heart
Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology. MPS offer an advanced in vitro platform that can be used to study human organ and tissue level functions in health and in diseased...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1213959/full |
| _version_ | 1797785740578390016 |
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| author | Hanna Vuorenpää Hanna Vuorenpää Hanna Vuorenpää Miina Björninen Miina Björninen Miina Björninen Hannu Välimäki Hannu Välimäki Antti Ahola Antti Ahola Mart Kroon Mart Kroon Laura Honkamäki Laura Honkamäki Jussi T. Koivumäki Jussi T. Koivumäki Mari Pekkanen-Mattila Mari Pekkanen-Mattila |
| author_facet | Hanna Vuorenpää Hanna Vuorenpää Hanna Vuorenpää Miina Björninen Miina Björninen Miina Björninen Hannu Välimäki Hannu Välimäki Antti Ahola Antti Ahola Mart Kroon Mart Kroon Laura Honkamäki Laura Honkamäki Jussi T. Koivumäki Jussi T. Koivumäki Mari Pekkanen-Mattila Mari Pekkanen-Mattila |
| author_sort | Hanna Vuorenpää |
| collection | DOAJ |
| description | Microphysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology. MPS offer an advanced in vitro platform that can be used to study human organ and tissue level functions in health and in diseased states more accurately than traditional single cell cultures or even animal models. Key features in MPS include microenvironmental control and monitoring as well as high biological complexity of the target tissue. To reach these qualities, cross-disciplinary collaboration from multiple fields of science is required to build MPS. Here, we review different areas of expertise and describe essential building blocks of heart MPS including relevant cardiac cell types, supporting matrix, mechanical stimulation, functional measurements, and computational modelling. The review presents current methods in cardiac MPS and provides insights for future MPS development with improved recapitulation of human physiology. |
| first_indexed | 2024-03-13T00:58:15Z |
| format | Article |
| id | doaj.art-92f0776a54f3407590a917783ff7a8ff |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-13T00:58:15Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-92f0776a54f3407590a917783ff7a8ff2023-07-06T15:07:16ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-07-011410.3389/fphys.2023.12139591213959Building blocks of microphysiological system to model physiology and pathophysiology of human heartHanna Vuorenpää0Hanna Vuorenpää1Hanna Vuorenpää2Miina Björninen3Miina Björninen4Miina Björninen5Hannu Välimäki6Hannu Välimäki7Antti Ahola8Antti Ahola9Mart Kroon10Mart Kroon11Laura Honkamäki12Laura Honkamäki13Jussi T. Koivumäki14Jussi T. Koivumäki15Mari Pekkanen-Mattila16Mari Pekkanen-Mattila17Centre of Excellence in Body-on-Chip Research (CoEBoC), BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandAdult Stem Cell Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandResearch, Development and Innovation Centre, Tampere University Hospital, Tampere, FinlandCentre of Excellence in Body-on-Chip Research (CoEBoC), BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandAdult Stem Cell Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandResearch, Development and Innovation Centre, Tampere University Hospital, Tampere, FinlandCentre of Excellence in Body-on-Chip Research (CoEBoC), BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandMicro- and Nanosystems Research Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCentre of Excellence in Body-on-Chip Research (CoEBoC), BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandComputational Biophysics and Imaging Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCentre of Excellence in Body-on-Chip Research (CoEBoC), BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandBiomaterials and Tissue Engineering Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCentre of Excellence in Body-on-Chip Research (CoEBoC), BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandNeuro Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCentre of Excellence in Body-on-Chip Research (CoEBoC), BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandComputational Biophysics and Imaging Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandCentre of Excellence in Body-on-Chip Research (CoEBoC), BioMediTech, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandHeart Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandMicrophysiological systems (MPS) are drawing increasing interest from academia and from biomedical industry due to their improved capability to capture human physiology. MPS offer an advanced in vitro platform that can be used to study human organ and tissue level functions in health and in diseased states more accurately than traditional single cell cultures or even animal models. Key features in MPS include microenvironmental control and monitoring as well as high biological complexity of the target tissue. To reach these qualities, cross-disciplinary collaboration from multiple fields of science is required to build MPS. Here, we review different areas of expertise and describe essential building blocks of heart MPS including relevant cardiac cell types, supporting matrix, mechanical stimulation, functional measurements, and computational modelling. The review presents current methods in cardiac MPS and provides insights for future MPS development with improved recapitulation of human physiology.https://www.frontiersin.org/articles/10.3389/fphys.2023.1213959/fullcardiac modelingmicrophysiological systemsin vitroin silicoco-culturesbiomaterials |
| spellingShingle | Hanna Vuorenpää Hanna Vuorenpää Hanna Vuorenpää Miina Björninen Miina Björninen Miina Björninen Hannu Välimäki Hannu Välimäki Antti Ahola Antti Ahola Mart Kroon Mart Kroon Laura Honkamäki Laura Honkamäki Jussi T. Koivumäki Jussi T. Koivumäki Mari Pekkanen-Mattila Mari Pekkanen-Mattila Building blocks of microphysiological system to model physiology and pathophysiology of human heart Frontiers in Physiology cardiac modeling microphysiological systems in vitro in silico co-cultures biomaterials |
| title | Building blocks of microphysiological system to model physiology and pathophysiology of human heart |
| title_full | Building blocks of microphysiological system to model physiology and pathophysiology of human heart |
| title_fullStr | Building blocks of microphysiological system to model physiology and pathophysiology of human heart |
| title_full_unstemmed | Building blocks of microphysiological system to model physiology and pathophysiology of human heart |
| title_short | Building blocks of microphysiological system to model physiology and pathophysiology of human heart |
| title_sort | building blocks of microphysiological system to model physiology and pathophysiology of human heart |
| topic | cardiac modeling microphysiological systems in vitro in silico co-cultures biomaterials |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1213959/full |
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