Accessing Nystatin through Mariculture
Understanding our oceans and their marine ecosystems has enabled the development of sustainable systems for mariculture. While the bulk of studies to date have focused on the production of food, its remarkable expanse has inspired the translation of other markets towards aquatic environments. This m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/24/7649 |
| _version_ | 1797502127686287360 |
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| author | James J. La Clair |
| author_facet | James J. La Clair |
| author_sort | James J. La Clair |
| collection | DOAJ |
| description | Understanding our oceans and their marine ecosystems has enabled the development of sustainable systems for mariculture. While the bulk of studies to date have focused on the production of food, its remarkable expanse has inspired the translation of other markets towards aquatic environments. This manuscript outlines an approach to pharmaceutical mariculture, by demonstrating a benchmark for future prototyping. Here, design, field evaluation and natural product chemistry are united to successfully produce nystatin at sea. This study begins by evaluating new designs for culture flasks, illustrating a next step towards developing self-contained bioreactors for culturing in marine environments. Through pilot studies, an underwater system was developed to cost effectively produce cultures that yielded 200 mg of nystatin per deployment. Overall, this study demonstrates the potential for the practical culturing of microbes in a marine environment and provides an important next step for the fledgling field of molecular mariculture. |
| first_indexed | 2024-03-10T03:28:28Z |
| format | Article |
| id | doaj.art-92f24984a52c4e8885ba6f0e457b63d5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:28:28Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-92f24984a52c4e8885ba6f0e457b63d52023-11-23T09:47:21ZengMDPI AGMolecules1420-30492021-12-012624764910.3390/molecules26247649Accessing Nystatin through MaricultureJames J. La Clair0Xenobe Research Institute, P.O. Box 3052, San Diego, CA 92163-1052, USAUnderstanding our oceans and their marine ecosystems has enabled the development of sustainable systems for mariculture. While the bulk of studies to date have focused on the production of food, its remarkable expanse has inspired the translation of other markets towards aquatic environments. This manuscript outlines an approach to pharmaceutical mariculture, by demonstrating a benchmark for future prototyping. Here, design, field evaluation and natural product chemistry are united to successfully produce nystatin at sea. This study begins by evaluating new designs for culture flasks, illustrating a next step towards developing self-contained bioreactors for culturing in marine environments. Through pilot studies, an underwater system was developed to cost effectively produce cultures that yielded 200 mg of nystatin per deployment. Overall, this study demonstrates the potential for the practical culturing of microbes in a marine environment and provides an important next step for the fledgling field of molecular mariculture.https://www.mdpi.com/1420-3049/26/24/7649natural product productionmariculturedrug developmentmarine biotechnology |
| spellingShingle | James J. La Clair Accessing Nystatin through Mariculture Molecules natural product production mariculture drug development marine biotechnology |
| title | Accessing Nystatin through Mariculture |
| title_full | Accessing Nystatin through Mariculture |
| title_fullStr | Accessing Nystatin through Mariculture |
| title_full_unstemmed | Accessing Nystatin through Mariculture |
| title_short | Accessing Nystatin through Mariculture |
| title_sort | accessing nystatin through mariculture |
| topic | natural product production mariculture drug development marine biotechnology |
| url | https://www.mdpi.com/1420-3049/26/24/7649 |
| work_keys_str_mv | AT jamesjlaclair accessingnystatinthroughmariculture |