Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients
In healthy subjects, dual hemisphere transcranial direct current stimulation (tDCS) over the primary (S1) and secondary somatosensory cortices (S2) has been found to transiently enhance tactile performance. However, the effect of dual hemisphere tDCS on tactile performance in stroke patients with se...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00128/full |
| _version_ | 1818528375186128896 |
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| author | Shuhei eFujimoto Shuhei eFujimoto Shuhei eFujimoto Shuhei eFujimoto Noriko eKon Yohei eOtaka Yohei eOtaka Tomofumi eYamaguchi Tomofumi eYamaguchi Takeo eNakayama Kunistugu eKondo Patrick eRagert Patrick eRagert Satoshi eTanaka |
| author_facet | Shuhei eFujimoto Shuhei eFujimoto Shuhei eFujimoto Shuhei eFujimoto Noriko eKon Yohei eOtaka Yohei eOtaka Tomofumi eYamaguchi Tomofumi eYamaguchi Takeo eNakayama Kunistugu eKondo Patrick eRagert Patrick eRagert Satoshi eTanaka |
| author_sort | Shuhei eFujimoto |
| collection | DOAJ |
| description | In healthy subjects, dual hemisphere transcranial direct current stimulation (tDCS) over the primary (S1) and secondary somatosensory cortices (S2) has been found to transiently enhance tactile performance. However, the effect of dual hemisphere tDCS on tactile performance in stroke patients with sensory deficits remains unknown. The purpose of this study was to investigate whether dual hemisphere tDCS over S1 and S2 could enhance tactile discrimination in stroke patients. We employed a double-blind, crossover, sham-controlled experimental design. Eight chronic stroke patients with sensory deficits participated in this study. We used a grating orientation task (GOT) to measure the tactile discriminative threshold of the index finger on the lesioned side before, during, and 10 min after four tDCS conditions. For both the S1 and S2 conditions, we placed an anodal electrode over the lesioned hemisphere and a cathodal electrode over the opposite hemisphere. We applied tDCS at an intensity of 2 mA for 15 min in both S1 and S2 conditions. We included two sham conditions in which the positions of the electrodes and the current intensity were identical to that in the S1 and S2 conditions except that current was delivered for the initial 15 s only. We found that GOT thresholds during and 10 min after the S1 and S2 conditions were significantly lower compared with each sham condition. GOT thresholds were not significantly different between the S1 and S2 conditions at any time point. We concluded that dual-hemisphere tDCS over S1 and S2 can transiently enhance tactile discriminative task performance in chronic stroke patients with sensory dysfunction. |
| first_indexed | 2024-12-11T06:48:57Z |
| format | Article |
| id | doaj.art-92f43fcbec6948c3894256e2d1c275be |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-11T06:48:57Z |
| publishDate | 2016-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-92f43fcbec6948c3894256e2d1c275be2022-12-22T01:16:58ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2016-03-011010.3389/fnins.2016.00128181336Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patientsShuhei eFujimoto0Shuhei eFujimoto1Shuhei eFujimoto2Shuhei eFujimoto3Noriko eKon4Yohei eOtaka5Yohei eOtaka6Tomofumi eYamaguchi7Tomofumi eYamaguchi8Takeo eNakayama9Kunistugu eKondo10Patrick eRagert11Patrick eRagert12Satoshi eTanaka13Tokyo Bay Rehabilitation HospitalHamamatsu University School of MedicineKyoto University Graduate School of Public HealthMEDLEY,IncKyoto University Graduate School of Public HealthTokyo Bay Rehabilitation HospitalKeio University School of MedicineTokyo Bay Rehabilitation HospitalKeio University School of MedicineKyoto University Graduate School of Public HealthTokyo Bay Rehabilitation HospitalMax Planck Institute for Human Cognitive and Brain SciencesUniversity of LeipzigHamamatsu University School of MedicineIn healthy subjects, dual hemisphere transcranial direct current stimulation (tDCS) over the primary (S1) and secondary somatosensory cortices (S2) has been found to transiently enhance tactile performance. However, the effect of dual hemisphere tDCS on tactile performance in stroke patients with sensory deficits remains unknown. The purpose of this study was to investigate whether dual hemisphere tDCS over S1 and S2 could enhance tactile discrimination in stroke patients. We employed a double-blind, crossover, sham-controlled experimental design. Eight chronic stroke patients with sensory deficits participated in this study. We used a grating orientation task (GOT) to measure the tactile discriminative threshold of the index finger on the lesioned side before, during, and 10 min after four tDCS conditions. For both the S1 and S2 conditions, we placed an anodal electrode over the lesioned hemisphere and a cathodal electrode over the opposite hemisphere. We applied tDCS at an intensity of 2 mA for 15 min in both S1 and S2 conditions. We included two sham conditions in which the positions of the electrodes and the current intensity were identical to that in the S1 and S2 conditions except that current was delivered for the initial 15 s only. We found that GOT thresholds during and 10 min after the S1 and S2 conditions were significantly lower compared with each sham condition. GOT thresholds were not significantly different between the S1 and S2 conditions at any time point. We concluded that dual-hemisphere tDCS over S1 and S2 can transiently enhance tactile discriminative task performance in chronic stroke patients with sensory dysfunction.http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00128/fullGrating OrientationTranscranial magnetic stimulation (TMS)transcranial direct current stimulation (tDCS)Cortical PlasticityPalsyinter-hemispheric inhibition |
| spellingShingle | Shuhei eFujimoto Shuhei eFujimoto Shuhei eFujimoto Shuhei eFujimoto Noriko eKon Yohei eOtaka Yohei eOtaka Tomofumi eYamaguchi Tomofumi eYamaguchi Takeo eNakayama Kunistugu eKondo Patrick eRagert Patrick eRagert Satoshi eTanaka Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients Frontiers in Neuroscience Grating Orientation Transcranial magnetic stimulation (TMS) transcranial direct current stimulation (tDCS) Cortical Plasticity Palsy inter-hemispheric inhibition |
| title | Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients |
| title_full | Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients |
| title_fullStr | Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients |
| title_full_unstemmed | Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients |
| title_short | Transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients |
| title_sort | transcranial direct current stimulation over the primary and secondary somatosensory cortices transiently improves tactile spatial discrimination in stroke patients |
| topic | Grating Orientation Transcranial magnetic stimulation (TMS) transcranial direct current stimulation (tDCS) Cortical Plasticity Palsy inter-hemispheric inhibition |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00128/full |
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