The functional and anatomical characterization of three spinal output pathways of the anterolateral tract
Summary: The nature of spinal output pathways that convey nociceptive information to the brain has been the subject of controversy. Here, we provide anatomical, molecular, and functional characterizations of two distinct anterolateral pathways: one, ascending in the lateral spinal cord, triggers noc...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724001578 |
| _version_ | 1797291779801743360 |
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| author | Haichao Chen Isabel H. Bleimeister Eileen K. Nguyen Jie Li Abby Yilin Cui Harrison J. Stratton Kelly M. Smith Mark L. Baccei Sarah E. Ross |
| author_facet | Haichao Chen Isabel H. Bleimeister Eileen K. Nguyen Jie Li Abby Yilin Cui Harrison J. Stratton Kelly M. Smith Mark L. Baccei Sarah E. Ross |
| author_sort | Haichao Chen |
| collection | DOAJ |
| description | Summary: The nature of spinal output pathways that convey nociceptive information to the brain has been the subject of controversy. Here, we provide anatomical, molecular, and functional characterizations of two distinct anterolateral pathways: one, ascending in the lateral spinal cord, triggers nociceptive behaviors, and the other one, ascending in the ventral spinal cord, when inhibited, leads to sensorimotor deficits. Moreover, the lateral pathway consists of at least two subtypes. The first is a contralateral pathway that extends to the periaqueductal gray (PAG) and thalamus; the second is a bilateral pathway that projects to the bilateral parabrachial nucleus (PBN). Finally, we present evidence showing that activation of the contralateral pathway is sufficient for defensive behaviors such as running and freezing, whereas the bilateral pathway is sufficient for attending behaviors such as licking and guarding. This work offers insight into the complex organizational logic of the anterolateral system in the mouse. |
| first_indexed | 2024-03-07T19:42:39Z |
| format | Article |
| id | doaj.art-92f4cc7c0b754df8b235682d3300f4e7 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-07T19:42:39Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-92f4cc7c0b754df8b235682d3300f4e72024-02-29T05:19:03ZengElsevierCell Reports2211-12472024-03-01433113829The functional and anatomical characterization of three spinal output pathways of the anterolateral tractHaichao Chen0Isabel H. Bleimeister1Eileen K. Nguyen2Jie Li3Abby Yilin Cui4Harrison J. Stratton5Kelly M. Smith6Mark L. Baccei7Sarah E. Ross8Tsinghua Medicine, Tsinghua University, Beijing 100084, China; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USAPittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA 15213, USAPittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Anesthesiology, Pain Research Center, University of Cincinnati Medical Center, Cincinnati, OH 45267, USAPittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USAPittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USAPittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USADepartment of Anesthesiology, Pain Research Center, University of Cincinnati Medical Center, Cincinnati, OH 45267, USAPittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15213, USA; Corresponding authorSummary: The nature of spinal output pathways that convey nociceptive information to the brain has been the subject of controversy. Here, we provide anatomical, molecular, and functional characterizations of two distinct anterolateral pathways: one, ascending in the lateral spinal cord, triggers nociceptive behaviors, and the other one, ascending in the ventral spinal cord, when inhibited, leads to sensorimotor deficits. Moreover, the lateral pathway consists of at least two subtypes. The first is a contralateral pathway that extends to the periaqueductal gray (PAG) and thalamus; the second is a bilateral pathway that projects to the bilateral parabrachial nucleus (PBN). Finally, we present evidence showing that activation of the contralateral pathway is sufficient for defensive behaviors such as running and freezing, whereas the bilateral pathway is sufficient for attending behaviors such as licking and guarding. This work offers insight into the complex organizational logic of the anterolateral system in the mouse.http://www.sciencedirect.com/science/article/pii/S2211124724001578CP: Neuroscience |
| spellingShingle | Haichao Chen Isabel H. Bleimeister Eileen K. Nguyen Jie Li Abby Yilin Cui Harrison J. Stratton Kelly M. Smith Mark L. Baccei Sarah E. Ross The functional and anatomical characterization of three spinal output pathways of the anterolateral tract Cell Reports CP: Neuroscience |
| title | The functional and anatomical characterization of three spinal output pathways of the anterolateral tract |
| title_full | The functional and anatomical characterization of three spinal output pathways of the anterolateral tract |
| title_fullStr | The functional and anatomical characterization of three spinal output pathways of the anterolateral tract |
| title_full_unstemmed | The functional and anatomical characterization of three spinal output pathways of the anterolateral tract |
| title_short | The functional and anatomical characterization of three spinal output pathways of the anterolateral tract |
| title_sort | functional and anatomical characterization of three spinal output pathways of the anterolateral tract |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724001578 |
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