Decreased in vivo glutamate/GABA ratio correlates with the social behavior deficit in a mouse model of autism spectrum disorder

Decreased in vivo glutamate/GABA ratio correlates with the social behavior deficit in a mouse model of autism spectrum disorder

Abstract To diagnose autism spectrum disorder (ASD), researchers have sought biomarkers whose alterations correlate with the susceptibility to ASD. However, biomarkers closely related to the pathophysiology of ASD are lacking. Even though excitation/inhibition (E/I) imbalance has been suggested as a...

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Bibliographic Details
Main Authors: Gaeun Park, Se Jin Jeon, In Ok Ko, Ji Hwan Park, Kyo Chul Lee, Min-Sik Kim, Chan Young Shin, Hyeonjin Kim, Yong-Seok Lee
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Molecular Brain
Subjects:
Autism spectrum disorder
E/I balance
Glu/GABA
Creatine
Sociability
Magnetic resonance spectroscopy
Online Access:https://doi.org/10.1186/s13041-022-00904-z

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