The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders
Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disorder of integrative areas of the brain, characterized by cognitive decline and disability resulting in negative impacts on the family of the patients and the health care services worldwide. AD involves oxidative stres...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.872594/full |
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| author | Sarha A. L. Queiroz Alyne M. M. Ton Thiago M. C. Pereira Thiago M. C. Pereira Bianca P. Campagnaro Larissa Martinelli Aitor Picos Manuel Campos-Toimil Elisardo C. Vasquez |
| author_facet | Sarha A. L. Queiroz Alyne M. M. Ton Thiago M. C. Pereira Thiago M. C. Pereira Bianca P. Campagnaro Larissa Martinelli Aitor Picos Manuel Campos-Toimil Elisardo C. Vasquez |
| author_sort | Sarha A. L. Queiroz |
| collection | DOAJ |
| description | Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disorder of integrative areas of the brain, characterized by cognitive decline and disability resulting in negative impacts on the family of the patients and the health care services worldwide. AD involves oxidative stress, neuroinflammation and accelerated apoptosis, accompanied by deposition of amyloid-β peptide plaques and tau protein-based neurofibrillary tangles in the central nervous system. Among the multiple factors that contribute to the onset and evolution of this disease, aging stands out. That is why the prevalence of this disease has increased due to the constant increase in life expectancy. In the hope of finding new, more effective methods to slow the progression of this disease, over the last two decades, researchers have promoted “omics”-based approaches that include the gut microbiota and their reciprocal interactions with different targets in the body. This scientific advance has also led to a better understanding of brain compartments and the mechanisms that affect the integrity of the blood-brain barrier. This review aims to discuss recent advances related to the gut-brain-microbiota axis in AD. Furthermore, considering that AD involves psychiatric symptoms, this review also focuses on the psychiatric factors that interact with this axis (an issue that has not yet been sufficiently addressed in the literature). |
| first_indexed | 2024-04-13T21:21:08Z |
| format | Article |
| id | doaj.art-92f5905e0cef4241b97544198c5e8888 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T21:21:08Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-92f5905e0cef4241b97544198c5e88882022-12-22T02:29:29ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-06-011310.3389/fpsyt.2022.872594872594The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric DisordersSarha A. L. Queiroz0Alyne M. M. Ton1Thiago M. C. Pereira2Thiago M. C. Pereira3Bianca P. Campagnaro4Larissa Martinelli5Aitor Picos6Manuel Campos-Toimil7Elisardo C. Vasquez8Laboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University, Vila Velha, BrazilLaboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University, Vila Velha, BrazilLaboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University, Vila Velha, BrazilFederal Institute of Education, Science and Technology (IFES), Vila Velha, BrazilLaboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University, Vila Velha, BrazilLaboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University, Vila Velha, BrazilPhysiology and Pharmacology of Chronic Diseases (FIFAEC), Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela, SpainPhysiology and Pharmacology of Chronic Diseases (FIFAEC), Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela, Santiago de Compostela, SpainLaboratory of Translational Physiology and Pharmacology, Pharmaceutical Sciences Graduate Program, Vila Velha University, Vila Velha, BrazilAlzheimer's disease (AD) is a progressive and incurable neurodegenerative disorder of integrative areas of the brain, characterized by cognitive decline and disability resulting in negative impacts on the family of the patients and the health care services worldwide. AD involves oxidative stress, neuroinflammation and accelerated apoptosis, accompanied by deposition of amyloid-β peptide plaques and tau protein-based neurofibrillary tangles in the central nervous system. Among the multiple factors that contribute to the onset and evolution of this disease, aging stands out. That is why the prevalence of this disease has increased due to the constant increase in life expectancy. In the hope of finding new, more effective methods to slow the progression of this disease, over the last two decades, researchers have promoted “omics”-based approaches that include the gut microbiota and their reciprocal interactions with different targets in the body. This scientific advance has also led to a better understanding of brain compartments and the mechanisms that affect the integrity of the blood-brain barrier. This review aims to discuss recent advances related to the gut-brain-microbiota axis in AD. Furthermore, considering that AD involves psychiatric symptoms, this review also focuses on the psychiatric factors that interact with this axis (an issue that has not yet been sufficiently addressed in the literature).https://www.frontiersin.org/articles/10.3389/fpsyt.2022.872594/fullAlzheimer's diseasemicrobiota-gut-brain axisdysbiosisprobioticneuropsychiatric symptoms |
| spellingShingle | Sarha A. L. Queiroz Alyne M. M. Ton Thiago M. C. Pereira Thiago M. C. Pereira Bianca P. Campagnaro Larissa Martinelli Aitor Picos Manuel Campos-Toimil Elisardo C. Vasquez The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders Frontiers in Psychiatry Alzheimer's disease microbiota-gut-brain axis dysbiosis probiotic neuropsychiatric symptoms |
| title | The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders |
| title_full | The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders |
| title_fullStr | The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders |
| title_full_unstemmed | The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders |
| title_short | The Gut Microbiota-Brain Axis: A New Frontier on Neuropsychiatric Disorders |
| title_sort | gut microbiota brain axis a new frontier on neuropsychiatric disorders |
| topic | Alzheimer's disease microbiota-gut-brain axis dysbiosis probiotic neuropsychiatric symptoms |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.872594/full |
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