Bioinspired Magnetic Nanochains for Medicine
Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely used for medicine, both in therapy and diagnosis. Their guided assembly into anisotropic structures, such as nanochains, has recently opened new research avenues; for instance, targeted drug delivery. Interestingly, magnetic nanoch...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/8/1262 |
| _version_ | 1827684379905753088 |
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| author | Slavko Kralj Silvia Marchesan |
| author_facet | Slavko Kralj Silvia Marchesan |
| author_sort | Slavko Kralj |
| collection | DOAJ |
| description | Superparamagnetic iron oxide nanoparticles (SPIONs) have been widely used for medicine, both in therapy and diagnosis. Their guided assembly into anisotropic structures, such as nanochains, has recently opened new research avenues; for instance, targeted drug delivery. Interestingly, magnetic nanochains do occur in nature, and they are thought to be involved in the navigation and geographic orientation of a variety of animals and bacteria, although many open questions on their formation and functioning remain. In this review, we will analyze what is known about the natural formation of magnetic nanochains, as well as the synthetic protocols to produce them in the laboratory, to conclude with an overview of medical applications and an outlook on future opportunities in this exciting research field. |
| first_indexed | 2024-03-10T08:28:29Z |
| format | Article |
| id | doaj.art-92f60f6685b545be9893df84601b22a9 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T08:28:29Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-92f60f6685b545be9893df84601b22a92023-11-22T09:15:10ZengMDPI AGPharmaceutics1999-49232021-08-01138126210.3390/pharmaceutics13081262Bioinspired Magnetic Nanochains for MedicineSlavko Kralj0Silvia Marchesan1Department for Materials Synthesis, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, SloveniaDepartment of Chemical and Pharmaceutical Sciences, University of Trieste, 34127 Trieste, ItalySuperparamagnetic iron oxide nanoparticles (SPIONs) have been widely used for medicine, both in therapy and diagnosis. Their guided assembly into anisotropic structures, such as nanochains, has recently opened new research avenues; for instance, targeted drug delivery. Interestingly, magnetic nanochains do occur in nature, and they are thought to be involved in the navigation and geographic orientation of a variety of animals and bacteria, although many open questions on their formation and functioning remain. In this review, we will analyze what is known about the natural formation of magnetic nanochains, as well as the synthetic protocols to produce them in the laboratory, to conclude with an overview of medical applications and an outlook on future opportunities in this exciting research field.https://www.mdpi.com/1999-4923/13/8/1262biomineralizationbiocompassmagnetotactic bacteriamagnetosome chainsmagnetic navigationmagnetic assembly |
| spellingShingle | Slavko Kralj Silvia Marchesan Bioinspired Magnetic Nanochains for Medicine Pharmaceutics biomineralization biocompass magnetotactic bacteria magnetosome chains magnetic navigation magnetic assembly |
| title | Bioinspired Magnetic Nanochains for Medicine |
| title_full | Bioinspired Magnetic Nanochains for Medicine |
| title_fullStr | Bioinspired Magnetic Nanochains for Medicine |
| title_full_unstemmed | Bioinspired Magnetic Nanochains for Medicine |
| title_short | Bioinspired Magnetic Nanochains for Medicine |
| title_sort | bioinspired magnetic nanochains for medicine |
| topic | biomineralization biocompass magnetotactic bacteria magnetosome chains magnetic navigation magnetic assembly |
| url | https://www.mdpi.com/1999-4923/13/8/1262 |
| work_keys_str_mv | AT slavkokralj bioinspiredmagneticnanochainsformedicine AT silviamarchesan bioinspiredmagneticnanochainsformedicine |