Network models of protein phosphorylation, acetylation, and ubiquitination connect metabolic and cell signaling pathways in lung cancer.
We analyzed large-scale post-translational modification (PTM) data to outline cell signaling pathways affected by tyrosine kinase inhibitors (TKIs) in ten lung cancer cell lines. Tyrosine phosphorylated, lysine ubiquitinated, and lysine acetylated proteins were concomitantly identified using sequent...
Main Authors: | Karen E Ross, Guolin Zhang, Cuneyt Akcora, Yu Lin, Bin Fang, John Koomen, Eric B Haura, Mark Grimes |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2023-03-01
|
Series: | PLoS Computational Biology |
Online Access: | https://doi.org/10.1371/journal.pcbi.1010690 |
Similar Items
-
Acetylation, Phosphorylation, Ubiquitination (Oh My!): Following Post-Translational Modifications on the Ubiquitin Road
by: Rachel E. Lacoursiere, et al.
Published: (2022-03-01) -
The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways
by: Rayene Berkane, et al.
Published: (2023-12-01) -
Ubiquitin turnover and endocytic trafficking in yeast are regulated by Ser57 phosphorylation of ubiquitin
by: Sora Lee, et al.
Published: (2017-11-01) -
Phosphorylation and activation of ubiquitin-specific protease-14 by Akt regulates the ubiquitin-proteasome system
by: Daichao Xu, et al.
Published: (2015-11-01) -
N-terminal acetylation can stabilize proteins independent of their ubiquitination
by: Bert van de Kooij, et al.
Published: (2023-04-01)