Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle
The purpose of this study was to investigate the effects of acacia polyphenol (AP) supplementation on exercise-induced oxidative stress in mouse liver and skeletal muscle. Plasma aspartate aminotransferase (AST), liver and skeletal muscle levels of thiobarbituric acid reactive substance (TBARS), and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-12-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/1/29 |
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| author | Koichi Yada Llion Arwyn Roberts Natsumi Oginome Katsuhiko Suzuki |
| author_facet | Koichi Yada Llion Arwyn Roberts Natsumi Oginome Katsuhiko Suzuki |
| author_sort | Koichi Yada |
| collection | DOAJ |
| description | The purpose of this study was to investigate the effects of acacia polyphenol (AP) supplementation on exercise-induced oxidative stress in mouse liver and skeletal muscle. Plasma aspartate aminotransferase (AST), liver and skeletal muscle levels of thiobarbituric acid reactive substance (TBARS), and levels of skeletal muscle protein carbonyls increased immediately after exhaustive exercise. Exhaustive exercise also decreased liver glutathione (GSH). These results suggest that the exhaustive exercise used in this study induced tissue damage and oxidative stress. Contrary to our expectations, AP supplementation increased plasma AST and alanine aminotransferase activities, liver levels of TBARS, and protein carbonyls. Furthermore, AP supplementation decreased glutathione and glutathione peroxidase activity in the liver. On the other hand, AP supplementation decreased TBARS levels in skeletal muscle. These results suggest that oral high-dose AP administration decreased oxidative stress in skeletal muscle but induced oxidative stress in the liver and increased hepatotoxicity. |
| first_indexed | 2024-03-12T10:38:49Z |
| format | Article |
| id | doaj.art-92fafc5bfcd14ffcb5dc5102dc9c2080 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T10:38:49Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-92fafc5bfcd14ffcb5dc5102dc9c20802023-09-02T08:21:21ZengMDPI AGAntioxidants2076-39212019-12-01912910.3390/antiox9010029antiox9010029Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal MuscleKoichi Yada0Llion Arwyn Roberts1Natsumi Oginome2Katsuhiko Suzuki3Faculty of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, JapanSchool of Allied Health Sciences, Griffith University, Gold Coast 4215, AustraliaGraduate School of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, JapanFaculty of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, JapanThe purpose of this study was to investigate the effects of acacia polyphenol (AP) supplementation on exercise-induced oxidative stress in mouse liver and skeletal muscle. Plasma aspartate aminotransferase (AST), liver and skeletal muscle levels of thiobarbituric acid reactive substance (TBARS), and levels of skeletal muscle protein carbonyls increased immediately after exhaustive exercise. Exhaustive exercise also decreased liver glutathione (GSH). These results suggest that the exhaustive exercise used in this study induced tissue damage and oxidative stress. Contrary to our expectations, AP supplementation increased plasma AST and alanine aminotransferase activities, liver levels of TBARS, and protein carbonyls. Furthermore, AP supplementation decreased glutathione and glutathione peroxidase activity in the liver. On the other hand, AP supplementation decreased TBARS levels in skeletal muscle. These results suggest that oral high-dose AP administration decreased oxidative stress in skeletal muscle but induced oxidative stress in the liver and increased hepatotoxicity.https://www.mdpi.com/2076-3921/9/1/29polyphenolsantioxidantsoxidative stresshepatotoxicityexhaustive exercise |
| spellingShingle | Koichi Yada Llion Arwyn Roberts Natsumi Oginome Katsuhiko Suzuki Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle Antioxidants polyphenols antioxidants oxidative stress hepatotoxicity exhaustive exercise |
| title | Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle |
| title_full | Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle |
| title_fullStr | Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle |
| title_full_unstemmed | Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle |
| title_short | Effect of Acacia Polyphenol Supplementation on Exercise-Induced Oxidative Stress in Mice Liver and Skeletal Muscle |
| title_sort | effect of acacia polyphenol supplementation on exercise induced oxidative stress in mice liver and skeletal muscle |
| topic | polyphenols antioxidants oxidative stress hepatotoxicity exhaustive exercise |
| url | https://www.mdpi.com/2076-3921/9/1/29 |
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