Histological and Histometrical Evaluation of two Synthetic Hydroxyapatite Based Biomaterials in the Experimental Periodontal Defects in Dogs
Aim: The present study was to evaluate histologically and histometrically the efficacy of Chitra granules in the regeneration of alveolar bone and to compare it with that of OsteoGenR (HA Resorb)™ in iatrogenically created alveolar bone defects in mongrel dogs. Materials and Methods: Four dogs...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4860/9892_CE(Ra)_F(Sh)_PF1(AJAK)_PFA(Sh)_PF2(PAG).pdf |
| Summary: | Aim: The present study was to evaluate histologically and
histometrically the efficacy of Chitra granules in the regeneration
of alveolar bone and to compare it with that of OsteoGenR (HA
Resorb)™ in iatrogenically created alveolar bone defects in
mongrel dogs.
Materials and Methods: Four dogs (16 sites) were used for
this split-mouth study. The animals were divided randomly into
two groups of two animals. Same animals were used as control
and test. Each dog had four implantation sites. The periodontal
defects were prepared by acute defect model. Animals were
sacrificed at 3 months (n=2), 6 months (n=2) and histologic and
histometric evaluation was carried out.
Statistical Analysis: The data was analysed using statistical
package Graph pad Software. Comparison of the hard and
soft tissue parameters in the two groups was done using the
Wilcoxan (Man Whitney), two tailed t-test. A p-value less than
0.05 were considered significant.
Results: Maturing bone with immature periodontal ligament
fibers were observed at three months and advanced
osteogenesis at six months with both the types of bone graft
materials. The mean values showed that amount of new bone
formed with OsteoGenR (HA Resorb)™ was slightly more than
that obtained by Chitra granules in histometric evaluation.
Conclusion: Histological study showed similar healing pattern
with both the types of bone graft materials with maturing
bone at 3 months and advanced osteogenesis at six months
in experimental intraosseous periodontal defects in dogs.
However, histological evaluation for longer period is necessary
to determine the time taken for complete replacement of the
bone graft materials with new bone. |
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| ISSN: | 2249-782X 0973-709X |