THE INFLUENCE OF INSULIN RESISTANCE ON THE FORMATION AND PROGRESSION OF METABOLIC SYNDROME COMPONENTS (THE RESULTS OF A FIVE-YEAR STUDY)
<p>The combination of risk factors that make up a metabolic syndrome increases the risk of cardiovascular disease and type 2 diabetes. In the presence of insulin resistance the effects of risk factors combine, thereby increasing the probability of the development of cardiovascular disease and...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | http://www.rpcardio.ru/jour/article/view/75 |
| _version_ | 1797717072065593344 |
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| author | G. E. Roytberg J. V. Dorosh O. O. Sharkhun |
| author_facet | G. E. Roytberg J. V. Dorosh O. O. Sharkhun |
| author_sort | G. E. Roytberg |
| collection | DOAJ |
| description | <p>The combination of risk factors that make up a metabolic syndrome increases the risk of cardiovascular disease and type 2 diabetes. In the presence of insulin resistance the effects of risk factors combine, thereby increasing the probability of the development of cardiovascular disease and its complications.</p><p><strong>Aim.</strong> To study the effect of insulin resistance on the formation and progression of metabolic syndrome components on the basis of a 5-year follow-up.</p><p><strong>Material and methods.</strong> An outpatient examination of clinically healthy patients aged 20-65 years (n=711; 327 men and 384 women) was conducted. The average body mass index did not exceed 34.5 kg/m2. Biochemical blood analysis was performed to assess the state of lipid and carbohydrate metabolism. Insulin resistance was diagnosed using HOMAIR>2.6.</p><p><strong>Results.</strong> It has been detected that patients with insulin resistance have significantly higher incidence of the combination of three or more components of the metabolic syndrome (p<0.01). The incidence of multicomponent syndrome among the examined patients with insulin resistance was 69.7%, which is 1.8 times higher than in patients with initially preserved tissue sensitivity to insulin.</p><p><strong>Conclusion.</strong> The follow-up study of patients with insulin resistance shows that in the absence of correction of metabolic disorders, the development of multicomponent disorders that make up a metabolic syndrome occurs.</p> |
| first_indexed | 2024-03-12T08:31:00Z |
| format | Article |
| id | doaj.art-92fda03718d44e3191eede98cf52ac78 |
| institution | Directory Open Access Journal |
| issn | 1819-6446 2225-3653 |
| language | English |
| last_indexed | 2024-03-12T08:31:00Z |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj.art-92fda03718d44e3191eede98cf52ac782023-09-02T17:43:16ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-0111213213810.1234/1819-6446-2015-2-132-13874THE INFLUENCE OF INSULIN RESISTANCE ON THE FORMATION AND PROGRESSION OF METABOLIC SYNDROME COMPONENTS (THE RESULTS OF A FIVE-YEAR STUDY)G. E. Roytberg0J. V. Dorosh1O. O. Sharkhun2Российский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссийский национальный исследовательский медицинский университет им. Н.И. ПироговаРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова<p>The combination of risk factors that make up a metabolic syndrome increases the risk of cardiovascular disease and type 2 diabetes. In the presence of insulin resistance the effects of risk factors combine, thereby increasing the probability of the development of cardiovascular disease and its complications.</p><p><strong>Aim.</strong> To study the effect of insulin resistance on the formation and progression of metabolic syndrome components on the basis of a 5-year follow-up.</p><p><strong>Material and methods.</strong> An outpatient examination of clinically healthy patients aged 20-65 years (n=711; 327 men and 384 women) was conducted. The average body mass index did not exceed 34.5 kg/m2. Biochemical blood analysis was performed to assess the state of lipid and carbohydrate metabolism. Insulin resistance was diagnosed using HOMAIR>2.6.</p><p><strong>Results.</strong> It has been detected that patients with insulin resistance have significantly higher incidence of the combination of three or more components of the metabolic syndrome (p<0.01). The incidence of multicomponent syndrome among the examined patients with insulin resistance was 69.7%, which is 1.8 times higher than in patients with initially preserved tissue sensitivity to insulin.</p><p><strong>Conclusion.</strong> The follow-up study of patients with insulin resistance shows that in the absence of correction of metabolic disorders, the development of multicomponent disorders that make up a metabolic syndrome occurs.</p>http://www.rpcardio.ru/jour/article/view/75метаболический синдроминсулинорезистентностьартериальная гипертониясахарный диабет |
| spellingShingle | G. E. Roytberg J. V. Dorosh O. O. Sharkhun THE INFLUENCE OF INSULIN RESISTANCE ON THE FORMATION AND PROGRESSION OF METABOLIC SYNDROME COMPONENTS (THE RESULTS OF A FIVE-YEAR STUDY) Рациональная фармакотерапия в кардиологии метаболический синдром инсулинорезистентность артериальная гипертония сахарный диабет |
| title | THE INFLUENCE OF INSULIN RESISTANCE ON THE FORMATION AND PROGRESSION OF METABOLIC SYNDROME COMPONENTS (THE RESULTS OF A FIVE-YEAR STUDY) |
| title_full | THE INFLUENCE OF INSULIN RESISTANCE ON THE FORMATION AND PROGRESSION OF METABOLIC SYNDROME COMPONENTS (THE RESULTS OF A FIVE-YEAR STUDY) |
| title_fullStr | THE INFLUENCE OF INSULIN RESISTANCE ON THE FORMATION AND PROGRESSION OF METABOLIC SYNDROME COMPONENTS (THE RESULTS OF A FIVE-YEAR STUDY) |
| title_full_unstemmed | THE INFLUENCE OF INSULIN RESISTANCE ON THE FORMATION AND PROGRESSION OF METABOLIC SYNDROME COMPONENTS (THE RESULTS OF A FIVE-YEAR STUDY) |
| title_short | THE INFLUENCE OF INSULIN RESISTANCE ON THE FORMATION AND PROGRESSION OF METABOLIC SYNDROME COMPONENTS (THE RESULTS OF A FIVE-YEAR STUDY) |
| title_sort | influence of insulin resistance on the formation and progression of metabolic syndrome components the results of a five year study |
| topic | метаболический синдром инсулинорезистентность артериальная гипертония сахарный диабет |
| url | http://www.rpcardio.ru/jour/article/view/75 |
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