Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study
BackgroundEpidemiological evidence suggests an association between lifestyle habits (smoking, alcohol consumption, tea, coffee intake, etc.) and gastric cancer (GC). However, the causal relationship remains uncertain. Therefore, the purpose of this study was to ascertain whether there is a causal co...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1224753/full |
| _version_ | 1797692946475122688 |
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| author | Yuegui Tan Zhao Wei Kun Liu Yuzhen Qin Wenqi Hui |
| author_facet | Yuegui Tan Zhao Wei Kun Liu Yuzhen Qin Wenqi Hui |
| author_sort | Yuegui Tan |
| collection | DOAJ |
| description | BackgroundEpidemiological evidence suggests an association between lifestyle habits (smoking, alcohol consumption, tea, coffee intake, etc.) and gastric cancer (GC). However, the causal relationship remains uncertain. Therefore, the purpose of this study was to ascertain whether there is a causal connection between them.MethodsTwo-sample Mendelian randomization (MR) analysis was performed using the publicly available Genome Wide Association Study summary datasets using six methods: inverse variance weighting (IVW), weighted median, MR using a Robust Adjusted Profile Score (MR.Raps), MR using a Robust Adjusted Profile Score (MR-PRESSO), Radial regression of MR, and Causal Analysis Using Summary Effect Estimates (CAUSE). A sensitivity analysis was conducted to assess the robustness of the results.ResultsIn an East Asian population, we found that increased tea intake reduced the risk of GC [odds ratio (OR)= 0.90, 95% confidence interval (CI)= 0.82-0.99, P = 0.037] while there was a positive association between smoking and GC (OR = 1.58, 95% CI = 1.04-2.39, P = 0.032). No causal relationship between alcohol and coffee intake and GC. Sensitivity analyses demonstrated the robustness of these causal associations.ConclusionsOur study suggests that tea intake may reduce the risk of GC, for which smoking is a potential risk factor. Nevertheless, a larger and more diverse sample size is needed for further validation. |
| first_indexed | 2024-03-12T02:36:29Z |
| format | Article |
| id | doaj.art-9301c0a916834a269a29f819168e203e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T02:36:29Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9301c0a916834a269a29f819168e203e2023-09-04T16:11:00ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-09-011310.3389/fonc.2023.12247531224753Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization studyYuegui Tan0Zhao Wei1Kun Liu2Yuzhen Qin3Wenqi Hui4Department of Pharmacy, Xi’an Fifth Hospital, Xian, Shaanxi, ChinaDepartment of Medicinal Chemistry, School of Pharmacy, Air Force Medical University, Xi’an, Shaanxi, ChinaDepartment of Epidemiology, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Air Force Medical University, Xi’an, Shaanxi, ChinaXi’an Jiaotong-liverpool University, XJTLU Wisdom Lake Academy of Pharmacy, Xian, Shaanxi, ChinaDepartment of Pharmacy, Xi’an Fifth Hospital, Xian, Shaanxi, ChinaBackgroundEpidemiological evidence suggests an association between lifestyle habits (smoking, alcohol consumption, tea, coffee intake, etc.) and gastric cancer (GC). However, the causal relationship remains uncertain. Therefore, the purpose of this study was to ascertain whether there is a causal connection between them.MethodsTwo-sample Mendelian randomization (MR) analysis was performed using the publicly available Genome Wide Association Study summary datasets using six methods: inverse variance weighting (IVW), weighted median, MR using a Robust Adjusted Profile Score (MR.Raps), MR using a Robust Adjusted Profile Score (MR-PRESSO), Radial regression of MR, and Causal Analysis Using Summary Effect Estimates (CAUSE). A sensitivity analysis was conducted to assess the robustness of the results.ResultsIn an East Asian population, we found that increased tea intake reduced the risk of GC [odds ratio (OR)= 0.90, 95% confidence interval (CI)= 0.82-0.99, P = 0.037] while there was a positive association between smoking and GC (OR = 1.58, 95% CI = 1.04-2.39, P = 0.032). No causal relationship between alcohol and coffee intake and GC. Sensitivity analyses demonstrated the robustness of these causal associations.ConclusionsOur study suggests that tea intake may reduce the risk of GC, for which smoking is a potential risk factor. Nevertheless, a larger and more diverse sample size is needed for further validation.https://www.frontiersin.org/articles/10.3389/fonc.2023.1224753/fullgastric cancerMendelian randomizationsmokingalcohol consumptiontea intakecoffee intake |
| spellingShingle | Yuegui Tan Zhao Wei Kun Liu Yuzhen Qin Wenqi Hui Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study Frontiers in Oncology gastric cancer Mendelian randomization smoking alcohol consumption tea intake coffee intake |
| title | Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study |
| title_full | Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study |
| title_fullStr | Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study |
| title_full_unstemmed | Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study |
| title_short | Lifestyle habits and gastric cancer in an East Asian population: a Mendelian randomization study |
| title_sort | lifestyle habits and gastric cancer in an east asian population a mendelian randomization study |
| topic | gastric cancer Mendelian randomization smoking alcohol consumption tea intake coffee intake |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1224753/full |
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