Comparison of Sensitivity and Specificity of Commercial Amphetamine Tests
Drug addiction is a disease that is characterized by a compulsion, a desire to take different substances permanently or for a certain period of time. Numerous negative incidents, such as crimes, work accidents and traffic accidents, are related to using illegal substances. Therefore, urine drug cass...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | AppliedChem |
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| Online Access: | https://www.mdpi.com/2673-9623/3/1/10 |
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| author | Aleksandra Miłos Marcin Gackowski Anna Przybylska Piotr Kośliński Marcin Koba |
| author_facet | Aleksandra Miłos Marcin Gackowski Anna Przybylska Piotr Kośliński Marcin Koba |
| author_sort | Aleksandra Miłos |
| collection | DOAJ |
| description | Drug addiction is a disease that is characterized by a compulsion, a desire to take different substances permanently or for a certain period of time. Numerous negative incidents, such as crimes, work accidents and traffic accidents, are related to using illegal substances. Therefore, urine drug cassette tests have become a screening tool. However, considering legal consequences of test result, the question arises of their performance and reliability. On this account, the main objective of this study was to evaluate the sensitivity and specificity of urine drug tests available on the commercial pharmaceutical market. Evaluated tests were immersed in synthetic urine diluent spiked with amphetamine at various concentrations also containing potentially interfering substances such as caffeine, paracetamol and acetylsalicylic acid, and after a certain period of time, it was observed whether the result was as expected. The reference method used in this study was high-performance liquid chromatography. The obtained results confirmed the declared cut-off as well as specificity of rapid diagnostic tests. |
| first_indexed | 2024-03-11T06:59:43Z |
| format | Article |
| id | doaj.art-9306558331a9402b808c9b1214ec8e0c |
| institution | Directory Open Access Journal |
| issn | 2673-9623 |
| language | English |
| last_indexed | 2024-03-11T06:59:43Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | AppliedChem |
| spelling | doaj.art-9306558331a9402b808c9b1214ec8e0c2023-11-17T09:19:56ZengMDPI AGAppliedChem2673-96232023-03-013114115210.3390/appliedchem3010010Comparison of Sensitivity and Specificity of Commercial Amphetamine TestsAleksandra Miłos0Marcin Gackowski1Anna Przybylska2Piotr Kośliński3Marcin Koba4Department of Toxicology and Bromatology, Faculty of Pharmacy, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, A. Jurasza 2 Street, PL-85089 Bydgoszcz, PolandDepartment of Toxicology and Bromatology, Faculty of Pharmacy, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, A. Jurasza 2 Street, PL-85089 Bydgoszcz, PolandDepartment of Toxicology and Bromatology, Faculty of Pharmacy, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, A. Jurasza 2 Street, PL-85089 Bydgoszcz, PolandDepartment of Toxicology and Bromatology, Faculty of Pharmacy, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, A. Jurasza 2 Street, PL-85089 Bydgoszcz, PolandDepartment of Toxicology and Bromatology, Faculty of Pharmacy, L. Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, A. Jurasza 2 Street, PL-85089 Bydgoszcz, PolandDrug addiction is a disease that is characterized by a compulsion, a desire to take different substances permanently or for a certain period of time. Numerous negative incidents, such as crimes, work accidents and traffic accidents, are related to using illegal substances. Therefore, urine drug cassette tests have become a screening tool. However, considering legal consequences of test result, the question arises of their performance and reliability. On this account, the main objective of this study was to evaluate the sensitivity and specificity of urine drug tests available on the commercial pharmaceutical market. Evaluated tests were immersed in synthetic urine diluent spiked with amphetamine at various concentrations also containing potentially interfering substances such as caffeine, paracetamol and acetylsalicylic acid, and after a certain period of time, it was observed whether the result was as expected. The reference method used in this study was high-performance liquid chromatography. The obtained results confirmed the declared cut-off as well as specificity of rapid diagnostic tests.https://www.mdpi.com/2673-9623/3/1/10amphetaminescassette testshigh-performance liquid chromatographyrapid drug detection test |
| spellingShingle | Aleksandra Miłos Marcin Gackowski Anna Przybylska Piotr Kośliński Marcin Koba Comparison of Sensitivity and Specificity of Commercial Amphetamine Tests AppliedChem amphetamines cassette tests high-performance liquid chromatography rapid drug detection test |
| title | Comparison of Sensitivity and Specificity of Commercial Amphetamine Tests |
| title_full | Comparison of Sensitivity and Specificity of Commercial Amphetamine Tests |
| title_fullStr | Comparison of Sensitivity and Specificity of Commercial Amphetamine Tests |
| title_full_unstemmed | Comparison of Sensitivity and Specificity of Commercial Amphetamine Tests |
| title_short | Comparison of Sensitivity and Specificity of Commercial Amphetamine Tests |
| title_sort | comparison of sensitivity and specificity of commercial amphetamine tests |
| topic | amphetamines cassette tests high-performance liquid chromatography rapid drug detection test |
| url | https://www.mdpi.com/2673-9623/3/1/10 |
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