Hyperuricemia is associated with more cardiometabolic risk factors in hypertensive younger Chinese adults than in elderly
BackgroundNumerous studies have shown that hyperuricemia (HUA) is associated with cardiovascular and renal outcomes, but few studies specifically explored the effect of age on this relationship. Therefore, our study aimed to explore the relationship between HUA and other cardiometabolic risk factors...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1133724/full |
| _version_ | 1827987794288443392 |
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| author | Xiaofeng Su Xiaofeng Su Jing Liu Jing Liu Ningling Sun Yong Huo the SUCCESS Investigation Group |
| author_facet | Xiaofeng Su Xiaofeng Su Jing Liu Jing Liu Ningling Sun Yong Huo the SUCCESS Investigation Group |
| author_sort | Xiaofeng Su |
| collection | DOAJ |
| description | BackgroundNumerous studies have shown that hyperuricemia (HUA) is associated with cardiovascular and renal outcomes, but few studies specifically explored the effect of age on this relationship. Therefore, our study aimed to explore the relationship between HUA and other cardiometabolic risk factors in different age groups.MethodsThis cross-section study used the data from Survey on uric acid in Chinese subjects with essential hypertension (SUCCESS). We performed multivariate logistic regressions in different age groups.ResultsAfter adjusting for potential confounders, among young and middle-aged adults less than 60, HUA was associated with higher body mass index (BMI, adjusted OR = 1.114, 95% CI: 1.057–1.174), higher fasting blood glucose (FBG, adjusted OR = 1.099, 95% CI: 1.003–1.205), triglycerides (TG, adjusted OR = 1.425, 95% CI: 1.247–1.629), higher low-density lipoprotein cholesterol (LDL-C, adjusted OR = 1.171, 95% CI: 1.025–1.337), and lower estimated glomerular filtration rate (eGFR, adjusted OR = 0.992, 95% CI: 0.988–0.996). Among elderly adults 60 years or older, HUA was associated with higher SBP (adjusted OR = 1.024, 95% CI: 1.005–1.042), higher TG (adjusted OR = 1.716, 95% CI: 1.466–2.009), and higher LDL-C (adjusted OR = 1.595, 95% CI: 1.366–1.863).ConclusionHUA is associated with more cardiometabolic risk factors in younger adults with hypertension (HT). Comprehensive management of HT with HUA is needed in clinical settings. |
| first_indexed | 2024-04-09T23:53:39Z |
| format | Article |
| id | doaj.art-9309a18ba0614c5c94b594e71c287924 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-09T23:53:39Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-9309a18ba0614c5c94b594e71c2879242023-03-17T04:50:44ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-03-011010.3389/fcvm.2023.11337241133724Hyperuricemia is associated with more cardiometabolic risk factors in hypertensive younger Chinese adults than in elderlyXiaofeng Su0Xiaofeng Su1Jing Liu2Jing Liu3Ningling Sun4Yong Huo5the SUCCESS Investigation GroupDepartment of Hypertension, Peking University People’s Hospital, Beijing, ChinaCardio-Metabolic Laboratory, Peking University People's Hospital, Beijing, ChinaDepartment of Hypertension, Peking University People’s Hospital, Beijing, ChinaCardio-Metabolic Laboratory, Peking University People's Hospital, Beijing, ChinaDepartment of Hypertension, Peking University People’s Hospital, Beijing, ChinaDepartment of Cardiology, Peking University First Hospital, Beijing, ChinaBackgroundNumerous studies have shown that hyperuricemia (HUA) is associated with cardiovascular and renal outcomes, but few studies specifically explored the effect of age on this relationship. Therefore, our study aimed to explore the relationship between HUA and other cardiometabolic risk factors in different age groups.MethodsThis cross-section study used the data from Survey on uric acid in Chinese subjects with essential hypertension (SUCCESS). We performed multivariate logistic regressions in different age groups.ResultsAfter adjusting for potential confounders, among young and middle-aged adults less than 60, HUA was associated with higher body mass index (BMI, adjusted OR = 1.114, 95% CI: 1.057–1.174), higher fasting blood glucose (FBG, adjusted OR = 1.099, 95% CI: 1.003–1.205), triglycerides (TG, adjusted OR = 1.425, 95% CI: 1.247–1.629), higher low-density lipoprotein cholesterol (LDL-C, adjusted OR = 1.171, 95% CI: 1.025–1.337), and lower estimated glomerular filtration rate (eGFR, adjusted OR = 0.992, 95% CI: 0.988–0.996). Among elderly adults 60 years or older, HUA was associated with higher SBP (adjusted OR = 1.024, 95% CI: 1.005–1.042), higher TG (adjusted OR = 1.716, 95% CI: 1.466–2.009), and higher LDL-C (adjusted OR = 1.595, 95% CI: 1.366–1.863).ConclusionHUA is associated with more cardiometabolic risk factors in younger adults with hypertension (HT). Comprehensive management of HT with HUA is needed in clinical settings.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1133724/fullhyperuricemiacardiometabolic risk factorshypertensionage-relatedcross-section study |
| spellingShingle | Xiaofeng Su Xiaofeng Su Jing Liu Jing Liu Ningling Sun Yong Huo the SUCCESS Investigation Group Hyperuricemia is associated with more cardiometabolic risk factors in hypertensive younger Chinese adults than in elderly Frontiers in Cardiovascular Medicine hyperuricemia cardiometabolic risk factors hypertension age-related cross-section study |
| title | Hyperuricemia is associated with more cardiometabolic risk factors in hypertensive younger Chinese adults than in elderly |
| title_full | Hyperuricemia is associated with more cardiometabolic risk factors in hypertensive younger Chinese adults than in elderly |
| title_fullStr | Hyperuricemia is associated with more cardiometabolic risk factors in hypertensive younger Chinese adults than in elderly |
| title_full_unstemmed | Hyperuricemia is associated with more cardiometabolic risk factors in hypertensive younger Chinese adults than in elderly |
| title_short | Hyperuricemia is associated with more cardiometabolic risk factors in hypertensive younger Chinese adults than in elderly |
| title_sort | hyperuricemia is associated with more cardiometabolic risk factors in hypertensive younger chinese adults than in elderly |
| topic | hyperuricemia cardiometabolic risk factors hypertension age-related cross-section study |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1133724/full |
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