Cytoskeletal Actin Structure in Osteosarcoma Cells Determines Metastatic Phenotype via Regulating Cell Stiffness, Migration, and Transmigration

Cytoskeletal Actin Structure in Osteosarcoma Cells Determines Metastatic Phenotype via Regulating Cell Stiffness, Migration, and Transmigration

Osteosarcoma is the most common primary malignant bone tumor. The cause of death due to osteosarcoma is typically a consequence of metastasis to the lung. Controlling metastasis leads to improved prognosis for osteosarcoma patients. The cell stiffness of several tumor types is involved in metastatic...

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Bibliographic Details
Main Authors: Kouji Kita, Kunihiro Asanuma, Takayuki Okamoto, Eiji Kawamoto, Koichi Nakamura, Tomohito Hagi, Tomoki Nakamura, Motomu Shimaoka, Akihiro Sudo
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Current Issues in Molecular Biology
Subjects:
metastasis
cell stiffness
atomic force microscopy
osteosarcoma cell line
actin cytoskeleton
Online Access:https://www.mdpi.com/1467-3045/43/3/89

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