Reconstitution of Functional Integrin αIIbβ3 and Its Activation in Plasma Membrane-Mimetic Lipid Environments

Reconstitution of Functional Integrin αIIbβ3 and Its Activation in Plasma Membrane-Mimetic Lipid Environments

The study of the platelet receptor integrin αIIbβ3 in a membrane-mimetic environment without interfering signalling pathways is crucial to understand protein structure and dynamics. Our understanding of this receptor and its sequential activation steps has been tremendously progressing using structu...

Full description

Bibliographic Details
Main Authors:	Una Janke, Alexandra Mitlehner, Aileen Weide, Theresia Gutmann, Mihaela Delcea
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Series:	Membranes
Subjects:	liposomes lipids integrin αIIbβ3 reconstitution detergents
Online Access:	https://www.mdpi.com/2077-0375/11/7/499

Similar Items

Synergistic effect of peptide inhibitors derived from the extracellular and intracellular domain of αIIb subunit of integrin αIIbβ3 on platelet activation and aggregation
by: Alexia V. Gkourogianni, et al.
Published: (2018-01-01)

Structure, signal transduction, activation, and inhibition of integrin αIIbβ3
by: Honglei Xin, et al.
Published: (2023-02-01)

Maximum likelihood approach suggests positive selection in platelet integrin αIIbβ3 in mammalian species
by: Luís Bernardo Pina-Cabral, et al.
Published: (2019-05-01)

Extracellular thiol isomerase ERp5 regulates integrin αIIbβ3 activation by inhibition of fibrinogen binding
by: Kaifei Sun, et al.
Published: (2025-12-01)

Extract of Seaweed Codium fragile Inhibits Integrin αIIbβ3-Induced Outside-in Signaling and Arterial Thrombosis
by: Tae In Kim, et al.
Published: (2021-07-01)

Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading
by: Wen Gao, et al.
Published: (2018-08-01)

Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting
by: Jiansong Huang, et al.
Published: (2019-03-01)

Transmembrane thiol isomerase TMX1 counterbalances the effect of ERp46 to inhibit platelet activation and integrin αIIbβ3 function
by: Zhenzhen Zhao, et al.
Published: (2024-07-01)

Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation
by: Jinmi Zou, et al.
Published: (2024-04-01)

Clot Retraction and Its Correlation with the Function of Platelet Integrin α<sub>IIb</sub>β<sub>3</sub>
by: Daniel Gao, et al.
Published: (2023-08-01)

Modulation of human platelet activation and in vivo vascular thrombosis by columbianadin: regulation by integrin αIIbβ3 inside-out but not outside-in signals
by: Shaw-Min Hou, et al.
Published: (2020-05-01)

Pharmacological actions of dieckol on modulation of platelet functions and thrombus formation via integrin αIIbβ3 and cAMP signaling
by: Muhammad Irfan, et al.
Published: (2022-03-01)

Ulmus parvifolia Modulates Platelet Functions and Inhibits Thrombus Formation by Regulating Integrin αIIbβ3 and cAMP Signaling
by: Muhammad Irfan, et al.
Published: (2020-05-01)

Glanzmann thrombasthenia complicated by frequent myeloproliferative neoplasm‐related thromboembolism: thrombosis occurring regardless of αIIbβIII integrin deficiency
by: Roger E. G. Schutgens, et al.
Published: (2021-09-01)

Development of the Integrated Computer Simulation Model of the Intracellular, Transmembrane, and Extracellular Domain of Platelet Integrin α<sub>IIb</sub>β<sub>3</sub> (Platelet Membrane Glycoprotein: GPIIb–IIIa)
by: Masamitsu Nakayama, et al.
Published: (2024-01-01)

CDH6‐activated αIIbβ3 crosstalks with α2β1 to trigger cellular adhesion and invasion in metastatic ovarian and renal cancers
by: Rubén A. Bartolomé, et al.
Published: (2021-07-01)

CD40L Activates Platelet Integrin αIIbβ3 by Binding to the Allosteric Site (Site 2) in a KGD-Independent Manner and HIGM1 Mutations Are Clustered in the Integrin-Binding Sites of CD40L
by: Yoko K. Takada, et al.
Published: (2023-07-01)

Preclinical studies of RUC-4, a novel platelet αIIbβ3 antagonist, in non-human primates and with human platelets
by: Spandana Vootukuri, et al.
Published: (2019-06-01)

Expression profiles of α-synuclein in cortical lesions of patients with FCD IIb and TSC, and FCD rats
by: Li Zhang, et al.
Published: (2023-11-01)

Aβ<sub>1–40</sub>-Induced Platelet Adhesion Is Ameliorated by Rosmarinic Acid through Inhibition of NADPH Oxidase/PKC-δ/Integrin α<sub>IIb</sub>β<sub>3</sub> Signaling
by: Bo Kyung Lee, et al.
Published: (2021-10-01)

Platelet Phenotype Analysis of COVID-19 Patients Reveals Progressive Changes in the Activation of Integrin αIIbβ3, F13A1, the SARS-CoV-2 Target EIF4A1 and Annexin A5
by: Huriye Ercan, et al.
Published: (2021-11-01)

Mechanisms of glabridin inhibition of integrin αIIbβ3 inside-out signals and NF-κB activation in human platelets
by: Wei-Chieh Huang, et al.
Published: (2023-06-01)

High-molecular-weight fucosylated glycosaminoglycan induces human platelet aggregation depending on αIIbβ3 and platelet secretion
by: Lisha Lin, et al.
Published: (2021-10-01)

Calculated mixing enthalpies of 11 IIB-IVB and IIB-VB binary alloy systems using a subregular model
by: Bangwei Z., et al.
Published: (2010-01-01)

Optimization of Detergent-Mediated Reconstitution of Influenza A M2 Protein into Proteoliposomes
by: Catherine H. Crouch, et al.
Published: (2018-11-01)

New αIIbβ3 variants in 28 Turkish Glanzmann patients; structural hypothesis for complex activation by residues variations in I-EGF domains
by: M Y Koker, et al.
Published: (2022-05-01)

Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation
by: Dan Shu, et al.
Published: (2021-04-01)

New insights into regulation of αIIbβ3 integrin signaling by filamin A
by: Lamia Lamrani, et al.
Published: (2022-02-01)

Type IIB urethral duplication in young adult—A case report
by: Naqibullah Foladi, MD, et al.
Published: (2020-08-01)

Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2
by: Adela Constantinescu-Bercu, et al.
Published: (2020-04-01)

Expression dynamics of integrin α2, α3, and αV upon osteogenic differentiation of human mesenchymal stem cells
by: Hyun Min Lee, et al.
Published: (2020-06-01)

Rumex acetosa modulates platelet function and inhibits thrombus formation in rats
by: Dahye Jeong, et al.
Published: (2020-03-01)

Integrin α6 targeted cancer imaging and therapy
by: Zhang Wenbiao, et al.
Published: (2023-01-01)

Integrin αV Mediates the Effects of Irisin on Human Mature Adipocytes
by: Tingting Fu, et al.
Published: (2022-03-01)

Toll-like receptors and integrins crosstalk
by: Fahd Alhamdan, et al.
Published: (2024-06-01)

Lipid Membrane Mimetics in Functional and Structural Studies of Integral Membrane Proteins
by: Saman Majeed, et al.
Published: (2021-09-01)

Constitutive activation of integrin αvβ3 contributes to anoikis resistance of ovarian cancer cells
by: Romana Dolinschek, et al.
Published: (2021-02-01)

Myricetin as a promising inhibitor of platelet fibrinogen receptor in humans
by: Yi Chang, et al.
Published: (2023-10-01)

Angiogenesis in the Outer Membrane of Chronic Subdural Hematomas through Thrombin-Cleaved Osteopontin and the Integrin α9 and Integrin β1 Signaling Pathways
by: Koji Osuka, et al.
Published: (2023-05-01)

Expressions of type I collagen, α2 integrin and β1 integrin in sclera of guinea pig with defocus myopia and inhibitory effects of bFGF on the formation of myopia
by: Xiao-Dan Tian
Published: (2013-02-01)