The role of Toll-like receptors in skin diseases
The innate immune system has the ability to recognize pathogens through Toll-like receptors (TLRs), which are transmembrane glycoproteins on the cell surface. These receptors present on the surface of immunological cells – macrophages, dendritic cells, mast cells and some populations of lymphocytes...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2014-09-01
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| Series: | Przegląd Dermatologiczny |
| Subjects: | |
| Online Access: | http://www.termedia.pl/The-role-of-Toll-like-receptors-in-skin-diseases,56,23497,1,1.html |
| _version_ | 1819096430160117760 |
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| author | Joanna Bacharewicz Teresa Reduta Iwona Flisiak |
| author_facet | Joanna Bacharewicz Teresa Reduta Iwona Flisiak |
| author_sort | Joanna Bacharewicz |
| collection | DOAJ |
| description | The innate immune system has the ability to recognize pathogens through Toll-like receptors (TLRs), which are transmembrane glycoproteins on the cell surface. These receptors present on the surface of immunological cells – macrophages, dendritic cells, mast cells and some populations of lymphocytes – play an important role in the defense against bacterial, viral and fungal infections. The connection of a Toll-like receptor with the microbial cell component known as pathogen associated molecular pattern (PAMP) induces intracellular mechanisms leading to the synthesis of proinflammatory cytokines. Depending on the kind of the recognized ligand, TLRs are classified into subfamilies. So far, 13 TLRs have been described in mice and 11 in humans. These receptors may be expressed extracellularly (TLRs 1, 2, 4, 5, 6, 10, 11) or intracellularly, located in endosomes (TLRs 3, 7, 8, 9). Recent studies also indicate their role in the development of many dermatoses. Occurrence of these receptors has been found on the surface of epidermal and dermal cells: keratinocytes, Langerhans cells, fibroblasts, endo-thelial cells, melanocytes and adipocytes. This paper presents the structure and function of Toll-like receptors and their role in the pathogenesis of some infectious skin diseases, autoimmune and allergic dermatoses as well as skin neoplasms. The knowledge about the role of Toll-like receptors in the development of skin diseases creates the possibility to use them in treatment in the future. |
| first_indexed | 2024-12-21T23:59:04Z |
| format | Article |
| id | doaj.art-930c54a0470c4a71a489358afcbd69f8 |
| institution | Directory Open Access Journal |
| issn | 0033-2526 2084-9893 |
| language | English |
| last_indexed | 2024-12-21T23:59:04Z |
| publishDate | 2014-09-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Przegląd Dermatologiczny |
| spelling | doaj.art-930c54a0470c4a71a489358afcbd69f82022-12-21T18:45:45ZengTermedia Publishing HousePrzegląd Dermatologiczny0033-25262084-98932014-09-01101430931810.5114/dr.2014.4512623497The role of Toll-like receptors in skin diseasesJoanna BacharewiczTeresa RedutaIwona FlisiakThe innate immune system has the ability to recognize pathogens through Toll-like receptors (TLRs), which are transmembrane glycoproteins on the cell surface. These receptors present on the surface of immunological cells – macrophages, dendritic cells, mast cells and some populations of lymphocytes – play an important role in the defense against bacterial, viral and fungal infections. The connection of a Toll-like receptor with the microbial cell component known as pathogen associated molecular pattern (PAMP) induces intracellular mechanisms leading to the synthesis of proinflammatory cytokines. Depending on the kind of the recognized ligand, TLRs are classified into subfamilies. So far, 13 TLRs have been described in mice and 11 in humans. These receptors may be expressed extracellularly (TLRs 1, 2, 4, 5, 6, 10, 11) or intracellularly, located in endosomes (TLRs 3, 7, 8, 9). Recent studies also indicate their role in the development of many dermatoses. Occurrence of these receptors has been found on the surface of epidermal and dermal cells: keratinocytes, Langerhans cells, fibroblasts, endo-thelial cells, melanocytes and adipocytes. This paper presents the structure and function of Toll-like receptors and their role in the pathogenesis of some infectious skin diseases, autoimmune and allergic dermatoses as well as skin neoplasms. The knowledge about the role of Toll-like receptors in the development of skin diseases creates the possibility to use them in treatment in the future.http://www.termedia.pl/The-role-of-Toll-like-receptors-in-skin-diseases,56,23497,1,1.htmlToll-like receptors function skin diseases |
| spellingShingle | Joanna Bacharewicz Teresa Reduta Iwona Flisiak The role of Toll-like receptors in skin diseases Przegląd Dermatologiczny Toll-like receptors function skin diseases |
| title | The role of Toll-like receptors in skin diseases |
| title_full | The role of Toll-like receptors in skin diseases |
| title_fullStr | The role of Toll-like receptors in skin diseases |
| title_full_unstemmed | The role of Toll-like receptors in skin diseases |
| title_short | The role of Toll-like receptors in skin diseases |
| title_sort | role of toll like receptors in skin diseases |
| topic | Toll-like receptors function skin diseases |
| url | http://www.termedia.pl/The-role-of-Toll-like-receptors-in-skin-diseases,56,23497,1,1.html |
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