Association between glycemic control and albuminuria among Peruvian adults with diabetes mellitus 2: a cross-sectional analytical study
ABSTRACT BACKGROUND: Albuminuria is a risk factor for microvascular and macrovascular complications in the diabetic population. However, few studies have correlated poor glycemic control and albuminuria prevalence in Hispanic populations. OBJECTIVE: To evaluate the association between glycemic con...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
2022-07-01
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022005017201&tlng=en |
| _version_ | 1811295362195914752 |
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| author | Lucero Del Carmen Collazos-Huamán Camila Guerreros-Espino Percy Herrera-Añazco Vicente Aleixandre Benites-Zapata |
| author_facet | Lucero Del Carmen Collazos-Huamán Camila Guerreros-Espino Percy Herrera-Añazco Vicente Aleixandre Benites-Zapata |
| author_sort | Lucero Del Carmen Collazos-Huamán |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Albuminuria is a risk factor for microvascular and macrovascular complications in the diabetic population. However, few studies have correlated poor glycemic control and albuminuria prevalence in Hispanic populations. OBJECTIVE: To evaluate the association between glycemic control and albuminuria among Peruvian adults with type 2 diabetes mellitus (T2DM). DESIGN AND SETTING: Cross-sectional analytical study among adults with T2DM in Lima, Peru. METHODS: We included adults over 18 years old who were in a clinical follow-up program at a private clinic in Lima in 2018. Poor glycemic control was defined as a serum value of glycosylated hemoglobin A1C (HbA1C) ≥ 7%. Albuminuria was defined as albumin values > 30 mg/dl in the first morning urine. We generated generalized linear regression models from the Poisson family with robust variance. We calculated the crude and adjusted prevalence ratios (PRs) with their 95% confidence interval (CI). RESULTS: We analyzed 907 participants of median age 58 years (interquartile range, IQR 49 to 66), and 62.8% were males. The prevalence of poor glycemic control was 39.8%, and the prevalence of albuminuria was 22.7%. The prevalences of albuminuria in groups with poor glycemic control and adequate glycemic control were 32.7% and 16.1%, respectively. In the adjusted regression analysis, we found a statistically significant association between poor glycemic control and albuminuria (annual percentage rate, aPR = 1.70; 95% CI: 1.28-2.27). CONCLUSIONS: The prevalence of poor glycemic control and albuminuria was high in our study population. Moreover, Peruvian T2DM adults with poor glycemic control were more likely to have albuminuria. |
| first_indexed | 2024-04-13T05:32:13Z |
| format | Article |
| id | doaj.art-930f944b6d5144d8ab39c210a2abd75a |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-04-13T05:32:13Z |
| publishDate | 2022-07-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-930f944b6d5144d8ab39c210a2abd75a2022-12-22T03:00:24ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602022-07-0110.1590/1516-3180.2021.0448.r2.07022022Association between glycemic control and albuminuria among Peruvian adults with diabetes mellitus 2: a cross-sectional analytical studyLucero Del Carmen Collazos-Huamánhttps://orcid.org/0000-0002-9314-1181Camila Guerreros-Espinohttps://orcid.org/0000-0002-3170-2254Percy Herrera-Añazcohttps://orcid.org/0000-0003-0282-6634Vicente Aleixandre Benites-Zapatahttps://orcid.org/0000-0002-9158-1108ABSTRACT BACKGROUND: Albuminuria is a risk factor for microvascular and macrovascular complications in the diabetic population. However, few studies have correlated poor glycemic control and albuminuria prevalence in Hispanic populations. OBJECTIVE: To evaluate the association between glycemic control and albuminuria among Peruvian adults with type 2 diabetes mellitus (T2DM). DESIGN AND SETTING: Cross-sectional analytical study among adults with T2DM in Lima, Peru. METHODS: We included adults over 18 years old who were in a clinical follow-up program at a private clinic in Lima in 2018. Poor glycemic control was defined as a serum value of glycosylated hemoglobin A1C (HbA1C) ≥ 7%. Albuminuria was defined as albumin values > 30 mg/dl in the first morning urine. We generated generalized linear regression models from the Poisson family with robust variance. We calculated the crude and adjusted prevalence ratios (PRs) with their 95% confidence interval (CI). RESULTS: We analyzed 907 participants of median age 58 years (interquartile range, IQR 49 to 66), and 62.8% were males. The prevalence of poor glycemic control was 39.8%, and the prevalence of albuminuria was 22.7%. The prevalences of albuminuria in groups with poor glycemic control and adequate glycemic control were 32.7% and 16.1%, respectively. In the adjusted regression analysis, we found a statistically significant association between poor glycemic control and albuminuria (annual percentage rate, aPR = 1.70; 95% CI: 1.28-2.27). CONCLUSIONS: The prevalence of poor glycemic control and albuminuria was high in our study population. Moreover, Peruvian T2DM adults with poor glycemic control were more likely to have albuminuria.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022005017201&tlng=enDiabetes mellitusAlbuminuriaGlycated hemoglobin ADiabetes complicationsPeruChronic kidney diseaseDiabetic nephropathyKidney disease |
| spellingShingle | Lucero Del Carmen Collazos-Huamán Camila Guerreros-Espino Percy Herrera-Añazco Vicente Aleixandre Benites-Zapata Association between glycemic control and albuminuria among Peruvian adults with diabetes mellitus 2: a cross-sectional analytical study São Paulo Medical Journal Diabetes mellitus Albuminuria Glycated hemoglobin A Diabetes complications Peru Chronic kidney disease Diabetic nephropathy Kidney disease |
| title | Association between glycemic control and albuminuria among Peruvian adults with diabetes mellitus 2: a cross-sectional analytical study |
| title_full | Association between glycemic control and albuminuria among Peruvian adults with diabetes mellitus 2: a cross-sectional analytical study |
| title_fullStr | Association between glycemic control and albuminuria among Peruvian adults with diabetes mellitus 2: a cross-sectional analytical study |
| title_full_unstemmed | Association between glycemic control and albuminuria among Peruvian adults with diabetes mellitus 2: a cross-sectional analytical study |
| title_short | Association between glycemic control and albuminuria among Peruvian adults with diabetes mellitus 2: a cross-sectional analytical study |
| title_sort | association between glycemic control and albuminuria among peruvian adults with diabetes mellitus 2 a cross sectional analytical study |
| topic | Diabetes mellitus Albuminuria Glycated hemoglobin A Diabetes complications Peru Chronic kidney disease Diabetic nephropathy Kidney disease |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022005017201&tlng=en |
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