Clinical utility of 18F-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma
ABSTRACT Objective To evaluate the clinical utility of 18F-FDG PET/CT in patients with high-risk DTC. Subjects and methods Single-center retrospective study with 74 patients with high-risk differentiated thyroid cancer (DTC), classified in 4 groups. Group 1: patients with positive sTg or TgAb, s...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Endocrinology and Metabolism
2017-09-01
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| Series: | Archives of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000500416&lng=en&tlng=en |
| _version_ | 1828875065576390656 |
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| author | Ji H. Yang Rui M. B. Maciel Claudia C. D. Nakabashi Carolina C. P. S. Janovsky Rosalia P. Padovani Danielle Macellaro Cléber P. Camacho Akemi Osawa Jairo Wagner Rosa Paula M. Biscolla |
| author_facet | Ji H. Yang Rui M. B. Maciel Claudia C. D. Nakabashi Carolina C. P. S. Janovsky Rosalia P. Padovani Danielle Macellaro Cléber P. Camacho Akemi Osawa Jairo Wagner Rosa Paula M. Biscolla |
| author_sort | Ji H. Yang |
| collection | DOAJ |
| description | ABSTRACT Objective To evaluate the clinical utility of 18F-FDG PET/CT in patients with high-risk DTC. Subjects and methods Single-center retrospective study with 74 patients with high-risk differentiated thyroid cancer (DTC), classified in 4 groups. Group 1: patients with positive sTg or TgAb, subdivided in Group 1A: negative RxWBS and no foci of metastases identified at conventional image (n = 9); Group 1B: RxWBS not compatible with suspicious foci at conventional image or not proportional to sTg level (n = 13); Group 2: patients with histological findings of aggressive DTC variants (n = 21) and Group 3: patients with positive RxWBS (n = 31). Results 18F-FDG PET/CT identified undifferentiated lesions and helped restage the disease in groups 1B and 2. The scan helped guide clinical judgment in 9/13 (69%) patients of group 1B, 10/21 (48%) patients of group 2 and 2/31 (6%) patients of group 3. There was no clinical benefit associated with group 1A. 18F-FDG PET/CT was associated with progressive disease. Conclusion 18F-FDG PET/CT is a useful tool in the follow-up of patients with high-risk DTC, mainly in the group of RxWBS not compatible with suspicious foci at conventional image or not proportional to sTg level and in those with aggressive DTC variants. Additionally, this study showed that 18F-FDG PET/CT was associated with progression and helped display undifferentiated lesions guiding clinical assessments regarding surgeries or expectant treatments. |
| first_indexed | 2024-12-13T07:51:23Z |
| format | Article |
| id | doaj.art-930fb6d03ae84d30b0df014b0ffa3b4f |
| institution | Directory Open Access Journal |
| issn | 2359-4292 |
| language | English |
| last_indexed | 2024-12-13T07:51:23Z |
| publishDate | 2017-09-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj.art-930fb6d03ae84d30b0df014b0ffa3b4f2022-12-21T23:54:40ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922017-09-0161541642510.1590/2359-3997000000285S2359-39972017000500416Clinical utility of 18F-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinomaJi H. YangRui M. B. MacielClaudia C. D. NakabashiCarolina C. P. S. JanovskyRosalia P. PadovaniDanielle MacellaroCléber P. CamachoAkemi OsawaJairo WagnerRosa Paula M. BiscollaABSTRACT Objective To evaluate the clinical utility of 18F-FDG PET/CT in patients with high-risk DTC. Subjects and methods Single-center retrospective study with 74 patients with high-risk differentiated thyroid cancer (DTC), classified in 4 groups. Group 1: patients with positive sTg or TgAb, subdivided in Group 1A: negative RxWBS and no foci of metastases identified at conventional image (n = 9); Group 1B: RxWBS not compatible with suspicious foci at conventional image or not proportional to sTg level (n = 13); Group 2: patients with histological findings of aggressive DTC variants (n = 21) and Group 3: patients with positive RxWBS (n = 31). Results 18F-FDG PET/CT identified undifferentiated lesions and helped restage the disease in groups 1B and 2. The scan helped guide clinical judgment in 9/13 (69%) patients of group 1B, 10/21 (48%) patients of group 2 and 2/31 (6%) patients of group 3. There was no clinical benefit associated with group 1A. 18F-FDG PET/CT was associated with progressive disease. Conclusion 18F-FDG PET/CT is a useful tool in the follow-up of patients with high-risk DTC, mainly in the group of RxWBS not compatible with suspicious foci at conventional image or not proportional to sTg level and in those with aggressive DTC variants. Additionally, this study showed that 18F-FDG PET/CT was associated with progression and helped display undifferentiated lesions guiding clinical assessments regarding surgeries or expectant treatments.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000500416&lng=en&tlng=enDifferentiated thyroid carcinoma18F-FDG PET/CTradioiodine (RAI)whole-body scan (WBS)thyroglobulin (Tg) |
| spellingShingle | Ji H. Yang Rui M. B. Maciel Claudia C. D. Nakabashi Carolina C. P. S. Janovsky Rosalia P. Padovani Danielle Macellaro Cléber P. Camacho Akemi Osawa Jairo Wagner Rosa Paula M. Biscolla Clinical utility of 18F-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma Archives of Endocrinology and Metabolism Differentiated thyroid carcinoma 18F-FDG PET/CT radioiodine (RAI) whole-body scan (WBS) thyroglobulin (Tg) |
| title | Clinical utility of 18F-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma |
| title_full | Clinical utility of 18F-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma |
| title_fullStr | Clinical utility of 18F-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma |
| title_full_unstemmed | Clinical utility of 18F-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma |
| title_short | Clinical utility of 18F-FDG PET/CT in the follow-up of a large cohort of patients with high-risk differentiated thyroid carcinoma |
| title_sort | clinical utility of 18f fdg pet ct in the follow up of a large cohort of patients with high risk differentiated thyroid carcinoma |
| topic | Differentiated thyroid carcinoma 18F-FDG PET/CT radioiodine (RAI) whole-body scan (WBS) thyroglobulin (Tg) |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972017000500416&lng=en&tlng=en |
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