Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84

Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84

Abstract GPR84 is an orphan class A G protein-coupled receptor (GPCR) that is predominantly expressed in immune cells and plays important roles in inflammation, fibrosis, and metabolism. Here, we present cryo-electron microscopy (cryo-EM) structures of Gαi protein-coupled human GPR84 bound to a synt...

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Bibliographic Details
Main Authors: Heng Liu, Qing Zhang, Xinheng He, Mengting Jiang, Siwei Wang, Xiaoci Yan, Xi Cheng, Yang Liu, Fa-Jun Nan, H. Eric Xu, Xin Xie, Wanchao Yin
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38985-6

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