Urinary triclosan is associated with elevated body mass index in NHANES.
Triclosan-a ubiquitous chemical in toothpastes, soaps, and household cleaning supplies-has the potential to alter both gut microbiota and endocrine function and thereby affect body weight.We investigated the relationship between triclosan and body mass index (BMI) using National Health and Nutrition...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3836985?pdf=render |
| _version_ | 1819135614458527744 |
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| author | Joanna Lankester Chirag Patel Mark R Cullen Catherine Ley Julie Parsonnet |
| author_facet | Joanna Lankester Chirag Patel Mark R Cullen Catherine Ley Julie Parsonnet |
| author_sort | Joanna Lankester |
| collection | DOAJ |
| description | Triclosan-a ubiquitous chemical in toothpastes, soaps, and household cleaning supplies-has the potential to alter both gut microbiota and endocrine function and thereby affect body weight.We investigated the relationship between triclosan and body mass index (BMI) using National Health and Nutrition Examination Surveys (NHANES) from 2003-2008. BMI and spot urinary triclosan levels were obtained from adults. Using two different exposure measures-either presence vs. absence or quartiles of triclosan-we assessed the association between triclosan and BMI. We also screened all NHANES serum and urine biomarkers to identify correlated factors that might confound observed associations.Compared with undetectable triclosan, a detectable level was associated with a 0.9-point increase in BMI (p<0.001). In analysis by quartile, compared to the lowest quartile, the 2nd, 3rd and 4th quartiles of urinary triclosan were associated with BMI increases of 1.5 (p<0.001), 1.0 (p = 0.002), and 0.3 (p = 0.33) respectively. The one strong correlate of triclosan identified in NHANES was its metabolite, 2,4-dichlorophenol (ρ = 0.4); its association with BMI, however, was weaker than that of triclosan. No other likely confounder was identified.Triclosan exposure is associated with increased BMI. Stronger effect at moderate than high levels suggests a complex mechanism of action. |
| first_indexed | 2024-12-22T10:21:53Z |
| format | Article |
| id | doaj.art-931256f6f96943bfa9b67788dce88ba3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T10:21:53Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-931256f6f96943bfa9b67788dce88ba32022-12-21T18:29:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01811e8005710.1371/journal.pone.0080057Urinary triclosan is associated with elevated body mass index in NHANES.Joanna LankesterChirag PatelMark R CullenCatherine LeyJulie ParsonnetTriclosan-a ubiquitous chemical in toothpastes, soaps, and household cleaning supplies-has the potential to alter both gut microbiota and endocrine function and thereby affect body weight.We investigated the relationship between triclosan and body mass index (BMI) using National Health and Nutrition Examination Surveys (NHANES) from 2003-2008. BMI and spot urinary triclosan levels were obtained from adults. Using two different exposure measures-either presence vs. absence or quartiles of triclosan-we assessed the association between triclosan and BMI. We also screened all NHANES serum and urine biomarkers to identify correlated factors that might confound observed associations.Compared with undetectable triclosan, a detectable level was associated with a 0.9-point increase in BMI (p<0.001). In analysis by quartile, compared to the lowest quartile, the 2nd, 3rd and 4th quartiles of urinary triclosan were associated with BMI increases of 1.5 (p<0.001), 1.0 (p = 0.002), and 0.3 (p = 0.33) respectively. The one strong correlate of triclosan identified in NHANES was its metabolite, 2,4-dichlorophenol (ρ = 0.4); its association with BMI, however, was weaker than that of triclosan. No other likely confounder was identified.Triclosan exposure is associated with increased BMI. Stronger effect at moderate than high levels suggests a complex mechanism of action.http://europepmc.org/articles/PMC3836985?pdf=render |
| spellingShingle | Joanna Lankester Chirag Patel Mark R Cullen Catherine Ley Julie Parsonnet Urinary triclosan is associated with elevated body mass index in NHANES. PLoS ONE |
| title | Urinary triclosan is associated with elevated body mass index in NHANES. |
| title_full | Urinary triclosan is associated with elevated body mass index in NHANES. |
| title_fullStr | Urinary triclosan is associated with elevated body mass index in NHANES. |
| title_full_unstemmed | Urinary triclosan is associated with elevated body mass index in NHANES. |
| title_short | Urinary triclosan is associated with elevated body mass index in NHANES. |
| title_sort | urinary triclosan is associated with elevated body mass index in nhanes |
| url | http://europepmc.org/articles/PMC3836985?pdf=render |
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