Clinical Classification of SARS-CoV-2 Positive Patients; Evaluation of Laboratory and Radiological Findings
Introduction: The sudden emergence and rapid spread of the Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has dangered global health. For this reason, there has been an urgent need to develop strategies to control the spread of the virus. In this study, we aimed to evaluate the cl...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bilimsel Tip Yayinevi
2021-09-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| Subjects: | |
| Online Access: | http://floradergisi.org/managete/fu_folder/2021-03/401-409%20Gonul%20Aslan.pdf |
| _version_ | 1797920587588304896 |
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| author | Şinasi KARVAR Harun GÜLBUDAK Yusuf GÖRGÜLÜ Seda TEZCAN ÜLGER Gülden ERSÖZ Mukadder ÇALIKOĞLU Mehmet Burak Yavuz ÇİMEN Yüksel BALCI Asena Ayça ÖZDEMİR Gamze YAPICI Nuran DELİALİOĞLU Gönül ASLAN |
| author_facet | Şinasi KARVAR Harun GÜLBUDAK Yusuf GÖRGÜLÜ Seda TEZCAN ÜLGER Gülden ERSÖZ Mukadder ÇALIKOĞLU Mehmet Burak Yavuz ÇİMEN Yüksel BALCI Asena Ayça ÖZDEMİR Gamze YAPICI Nuran DELİALİOĞLU Gönül ASLAN |
| author_sort | Şinasi KARVAR |
| collection | DOAJ |
| description | Introduction: The sudden emergence and rapid spread of the Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has dangered global health. For this reason, there has been an urgent need to develop strategies to control the spread of the virus. In this study, we aimed to evaluate the clinical, laboratory and chest computed tomography (CT) findings of COVID-19 cases with positive results of SARS-CoV-2 reverse transcription quantitative polymerase chain reaction (RT-qPCR).
Materials and Methods: A total of 278 patients aged 18 years and over who had positive SARS-CoV-2 RT-qPCR results and had access to laboratory and chest CT examinations between 15 April 2020 and 31 August 2020 were included in the study. Clinical classification of patients was performed as asymptomatic, mild and severe. Demographic information, laboratory tests and chest CT results of the patients were created with the data obtained from the hospital system and the relevant branch physicians. The data were analyzed statistically.
Results: In the study, 150 (54%) of the patients were males and 128 (46%) were females. Forty-two (15%) of these patients were classified as asymptomatic, 200 (72%) as mild and 36 (13%) as severe cases. Mean age of the patients was found to be 45.5 ± 17.5 years and 72 (25.9%) patients were found to have at least one comorbidity. Findings consistent with COVID-19 pneumonia were observed in the chest CT examinations of 42.4% (118/278) of the patients. The rate of findings in chest CT of severe patients (91.7%) was found higher than mild (38.5%) and asymptomatic cases (19%) (p< 0.05). When we examined the laboratory findings; 59.4% of the patients had elevated CRP, 42.1% lymphopenia, 41.1% elevated LDH, 40.6% elevated creatinine, 36% elevated AST, 20.1% leukopenia, 8% elevated ALT, 7.2% elevated leukocyte, 5.4% elevated troponin I and 3.3% elevated CK-MB were detected. In severe patients, lymphopenia (83.3%), neutrophil elevation (41.7%), CRP elevation (97.2%), LDH elevation (91.3%), troponin I elevation (21.4%) and AST elevation (63.9%) findings were observed at a higher rate than asymptomatic and mild cases (p< 0.05).
Conclusion: In our study, it was shown that the findings of high age, hypertension, diabetes mellitus, dyspnea, lymphopenia and the increase in neutrophil, CRP, LDH, troponin I and AST values were associated with severe clinical presentation. These findings are thought to be helpful in understanding the differences between clinical classes in COVID-19 patients. |
| first_indexed | 2024-04-10T14:03:34Z |
| format | Article |
| id | doaj.art-93146ef503b94f32a80d9c352aa605c2 |
| institution | Directory Open Access Journal |
| issn | 1300-932X |
| language | English |
| last_indexed | 2024-04-10T14:03:34Z |
| publishDate | 2021-09-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-93146ef503b94f32a80d9c352aa605c22023-02-15T16:10:08ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X2021-09-0126340140910.5578/flora.20219708Clinical Classification of SARS-CoV-2 Positive Patients; Evaluation of Laboratory and Radiological FindingsŞinasi KARVAR0https://orcid.org/0000-0003-3174-9674Harun GÜLBUDAK1https://orcid.org/0000-0003-3199-3132Yusuf GÖRGÜLÜ2https://orcid.org/0000-0002-8196-0948Seda TEZCAN ÜLGER3https://orcid.org/0000-0002-0823-3680Gülden ERSÖZ4https://orcid.org/0000-0003-2836-3586Mukadder ÇALIKOĞLU5https://orcid.org/0000-0001-6645-4652Mehmet Burak Yavuz ÇİMEN6https://orcid.org/0000-0002-1274-3499Yüksel BALCI7https://orcid.org/0000-0003-1758-9600Asena Ayça ÖZDEMİR8https://orcid.org/0000-0002-0108-1880Gamze YAPICI9https://orcid.org/0000-0001-8263-5680Nuran DELİALİOĞLU10https://orcid.org/0000-0001-8535-3291Gönül ASLAN11https://orcid.org/0000-0002-4431-3629Department of Medical Microbiology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Medical Microbiology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Medical Microbiology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Medical Microbiology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Chest Diseases, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Medical Biochemistry, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Radiology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Medicine Education, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Medical Microbiology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Medical Microbiology, Mersin University Faculty of Medicine, Mersin, TurkeyDepartment of Medical Microbiology, Mersin University Faculty of Medicine, Mersin, TurkeyIntroduction: The sudden emergence and rapid spread of the Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has dangered global health. For this reason, there has been an urgent need to develop strategies to control the spread of the virus. In this study, we aimed to evaluate the clinical, laboratory and chest computed tomography (CT) findings of COVID-19 cases with positive results of SARS-CoV-2 reverse transcription quantitative polymerase chain reaction (RT-qPCR). Materials and Methods: A total of 278 patients aged 18 years and over who had positive SARS-CoV-2 RT-qPCR results and had access to laboratory and chest CT examinations between 15 April 2020 and 31 August 2020 were included in the study. Clinical classification of patients was performed as asymptomatic, mild and severe. Demographic information, laboratory tests and chest CT results of the patients were created with the data obtained from the hospital system and the relevant branch physicians. The data were analyzed statistically. Results: In the study, 150 (54%) of the patients were males and 128 (46%) were females. Forty-two (15%) of these patients were classified as asymptomatic, 200 (72%) as mild and 36 (13%) as severe cases. Mean age of the patients was found to be 45.5 ± 17.5 years and 72 (25.9%) patients were found to have at least one comorbidity. Findings consistent with COVID-19 pneumonia were observed in the chest CT examinations of 42.4% (118/278) of the patients. The rate of findings in chest CT of severe patients (91.7%) was found higher than mild (38.5%) and asymptomatic cases (19%) (p< 0.05). When we examined the laboratory findings; 59.4% of the patients had elevated CRP, 42.1% lymphopenia, 41.1% elevated LDH, 40.6% elevated creatinine, 36% elevated AST, 20.1% leukopenia, 8% elevated ALT, 7.2% elevated leukocyte, 5.4% elevated troponin I and 3.3% elevated CK-MB were detected. In severe patients, lymphopenia (83.3%), neutrophil elevation (41.7%), CRP elevation (97.2%), LDH elevation (91.3%), troponin I elevation (21.4%) and AST elevation (63.9%) findings were observed at a higher rate than asymptomatic and mild cases (p< 0.05). Conclusion: In our study, it was shown that the findings of high age, hypertension, diabetes mellitus, dyspnea, lymphopenia and the increase in neutrophil, CRP, LDH, troponin I and AST values were associated with severe clinical presentation. These findings are thought to be helpful in understanding the differences between clinical classes in COVID-19 patients.http://floradergisi.org/managete/fu_folder/2021-03/401-409%20Gonul%20Aslan.pdfsars-cov-2covid-19crpcomputed tomography |
| spellingShingle | Şinasi KARVAR Harun GÜLBUDAK Yusuf GÖRGÜLÜ Seda TEZCAN ÜLGER Gülden ERSÖZ Mukadder ÇALIKOĞLU Mehmet Burak Yavuz ÇİMEN Yüksel BALCI Asena Ayça ÖZDEMİR Gamze YAPICI Nuran DELİALİOĞLU Gönül ASLAN Clinical Classification of SARS-CoV-2 Positive Patients; Evaluation of Laboratory and Radiological Findings Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi sars-cov-2 covid-19 crp computed tomography |
| title | Clinical Classification of SARS-CoV-2 Positive Patients; Evaluation of Laboratory and Radiological Findings |
| title_full | Clinical Classification of SARS-CoV-2 Positive Patients; Evaluation of Laboratory and Radiological Findings |
| title_fullStr | Clinical Classification of SARS-CoV-2 Positive Patients; Evaluation of Laboratory and Radiological Findings |
| title_full_unstemmed | Clinical Classification of SARS-CoV-2 Positive Patients; Evaluation of Laboratory and Radiological Findings |
| title_short | Clinical Classification of SARS-CoV-2 Positive Patients; Evaluation of Laboratory and Radiological Findings |
| title_sort | clinical classification of sars cov 2 positive patients evaluation of laboratory and radiological findings |
| topic | sars-cov-2 covid-19 crp computed tomography |
| url | http://floradergisi.org/managete/fu_folder/2021-03/401-409%20Gonul%20Aslan.pdf |
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