Some histopathological aspects of the disease related to IgG-4
The IgG4-related disease (IgG4-RD) is a recurrent chronic fibroinflammatory disease, probably of autoimmune origin, recently recognised. Its diagnosis is based on a combination of clinical, radiological, serological, histopathological and immunohistochemical data. However, the histopathology is cons...
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| Format: | Article |
| Language: | English |
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Permanyer
2015-04-01
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| Series: | Revista Médica del Hospital General de México |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0185106315000232 |
| _version_ | 1819111734556753920 |
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| author | Minerva Lazos-Ochoa |
| author_facet | Minerva Lazos-Ochoa |
| author_sort | Minerva Lazos-Ochoa |
| collection | DOAJ |
| description | The IgG4-related disease (IgG4-RD) is a recurrent chronic fibroinflammatory disease, probably of autoimmune origin, recently recognised. Its diagnosis is based on a combination of clinical, radiological, serological, histopathological and immunohistochemical data. However, the histopathology is considered as the golden “standard” for diagnosis. In most of the cases, the sum of lymphoplasmacytic inflammatory infiltrate with abundant IgG4+ plasma cells, storiform fibrosis and obliterative phlebitis makes a reliable diagnosis. Patients usually show elevated serum IgG4 concentrations and respond well to steroid therapy. Nowadays, IgG4-RD has been described in almost every organ: pancreatobiliary tract, liver, salivary glands, nasopharynx, bone marrow, lacrimal gland, extra-ocular muscles and retrobulbar space, kidney, lung, lymph nodes, meninges, aorta, skin, breast, prostate, thyroid gland and pericardium. |
| first_indexed | 2024-12-22T04:02:19Z |
| format | Article |
| id | doaj.art-93161a4056654d1aa5063e57d1a9f003 |
| institution | Directory Open Access Journal |
| issn | 0185-1063 |
| language | English |
| last_indexed | 2024-12-22T04:02:19Z |
| publishDate | 2015-04-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Revista Médica del Hospital General de México |
| spelling | doaj.art-93161a4056654d1aa5063e57d1a9f0032022-12-21T18:39:43ZengPermanyerRevista Médica del Hospital General de México0185-10632015-04-017829910410.1016/j.hgmx.2015.03.007Some histopathological aspects of the disease related to IgG-4Minerva Lazos-OchoaThe IgG4-related disease (IgG4-RD) is a recurrent chronic fibroinflammatory disease, probably of autoimmune origin, recently recognised. Its diagnosis is based on a combination of clinical, radiological, serological, histopathological and immunohistochemical data. However, the histopathology is considered as the golden “standard” for diagnosis. In most of the cases, the sum of lymphoplasmacytic inflammatory infiltrate with abundant IgG4+ plasma cells, storiform fibrosis and obliterative phlebitis makes a reliable diagnosis. Patients usually show elevated serum IgG4 concentrations and respond well to steroid therapy. Nowadays, IgG4-RD has been described in almost every organ: pancreatobiliary tract, liver, salivary glands, nasopharynx, bone marrow, lacrimal gland, extra-ocular muscles and retrobulbar space, kidney, lung, lymph nodes, meninges, aorta, skin, breast, prostate, thyroid gland and pericardium.http://www.sciencedirect.com/science/article/pii/S0185106315000232IgG4Sclerosing disease |
| spellingShingle | Minerva Lazos-Ochoa Some histopathological aspects of the disease related to IgG-4 Revista Médica del Hospital General de México IgG4 Sclerosing disease |
| title | Some histopathological aspects of the disease related to IgG-4 |
| title_full | Some histopathological aspects of the disease related to IgG-4 |
| title_fullStr | Some histopathological aspects of the disease related to IgG-4 |
| title_full_unstemmed | Some histopathological aspects of the disease related to IgG-4 |
| title_short | Some histopathological aspects of the disease related to IgG-4 |
| title_sort | some histopathological aspects of the disease related to igg 4 |
| topic | IgG4 Sclerosing disease |
| url | http://www.sciencedirect.com/science/article/pii/S0185106315000232 |
| work_keys_str_mv | AT minervalazosochoa somehistopathologicalaspectsofthediseaserelatedtoigg4 |