Whole Brain CT Perfusion Evaluation in Transient Ischaemic Attack: A Cross-sectional Study from a Tertiary Care Centre, New Delhi, India
Introduction: Few studies exist in current literature regarding imaging features in Transient Ischaemic Attack (TIA) and most of the previous studies on Computed Tomography Perfusion (CTP) have used old generation scanners with limited brain coverage. Aim: To study the spectrum of whole brain C...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2022-02-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/15994/50889_CE(Ra1)_F(SS)_PF1(SC_KM)_PFA(SC_KM)_PN(KM).pdf |
| _version_ | 1818059784683782144 |
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| author | Prateek Kumar Madaan Rohini Gupta Ghasi |
| author_facet | Prateek Kumar Madaan Rohini Gupta Ghasi |
| author_sort | Prateek Kumar Madaan |
| collection | DOAJ |
| description | Introduction: Few studies exist in current literature regarding
imaging features in Transient Ischaemic Attack (TIA) and most
of the previous studies on Computed Tomography Perfusion
(CTP) have used old generation scanners with limited brain
coverage.
Aim: To study the spectrum of whole brain CTP parameters in
patients presenting with TIA using a 256 slice CT scanner.
Materials and Methods: This cross-sectional observational study
was conducted on 15 patients, tertiary care centre in New Delhi,
India over a period of 18 months from October 2017 till March 2019.
All patients presenting with the first episode of TIA were evaluated
with Non Contrast Computed Tomography (NCCT), Whole brain
CTP, and Colour doppler of carotid vessels. Quantitative assessment
and statistical analysis of the alteration of CT perfusion parameters
was done in areas of visualised Focal Perfusion Abnormalities
(FPA) and seven predefined locations in bilateral hemispheres on
perfusion maps.
Results: Five out of 15 patients had FPAs in the colour maps
and there was a significant elevation of Cerebral Blood Flow
(CBF) and Cerebral Blood Volume (CBV) in the FPA region
(p-value=0.018) suggestive of postischaemic hyperperfusion. The
mean hemispheric CBF was increased in the abnormal hemisphere
compared to the normal hemisphere (p-value=0.04).
Conclusion: CTP parameters are significantly altered in the
patients with TIA with predominant increase in CBF and CBV in
the patients who have FPA on CTP. CTP shows postischaemic
hyperperfusion changes in the form of increased CBF in the
hemisphere corresponding to the symptoms.
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| first_indexed | 2024-12-10T13:22:02Z |
| format | Article |
| id | doaj.art-93168b848dc44f0487a886effade7dbb |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-10T13:22:02Z |
| publishDate | 2022-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-93168b848dc44f0487a886effade7dbb2022-12-22T01:47:19ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-02-01162TC11TC1610.7860/JCDR/2022/50889.15994Whole Brain CT Perfusion Evaluation in Transient Ischaemic Attack: A Cross-sectional Study from a Tertiary Care Centre, New Delhi, IndiaPrateek Kumar Madaan0Rohini Gupta Ghasi1Senior Resident, Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.Professor, Department of Radiodiagnosis, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.Introduction: Few studies exist in current literature regarding imaging features in Transient Ischaemic Attack (TIA) and most of the previous studies on Computed Tomography Perfusion (CTP) have used old generation scanners with limited brain coverage. Aim: To study the spectrum of whole brain CTP parameters in patients presenting with TIA using a 256 slice CT scanner. Materials and Methods: This cross-sectional observational study was conducted on 15 patients, tertiary care centre in New Delhi, India over a period of 18 months from October 2017 till March 2019. All patients presenting with the first episode of TIA were evaluated with Non Contrast Computed Tomography (NCCT), Whole brain CTP, and Colour doppler of carotid vessels. Quantitative assessment and statistical analysis of the alteration of CT perfusion parameters was done in areas of visualised Focal Perfusion Abnormalities (FPA) and seven predefined locations in bilateral hemispheres on perfusion maps. Results: Five out of 15 patients had FPAs in the colour maps and there was a significant elevation of Cerebral Blood Flow (CBF) and Cerebral Blood Volume (CBV) in the FPA region (p-value=0.018) suggestive of postischaemic hyperperfusion. The mean hemispheric CBF was increased in the abnormal hemisphere compared to the normal hemisphere (p-value=0.04). Conclusion: CTP parameters are significantly altered in the patients with TIA with predominant increase in CBF and CBV in the patients who have FPA on CTP. CTP shows postischaemic hyperperfusion changes in the form of increased CBF in the hemisphere corresponding to the symptoms. https://jcdr.net/articles/PDF/15994/50889_CE(Ra1)_F(SS)_PF1(SC_KM)_PFA(SC_KM)_PN(KM).pdfcerebrovascular accidentcomputed tomography perfusionpostischaemic hyperperfusionstroke |
| spellingShingle | Prateek Kumar Madaan Rohini Gupta Ghasi Whole Brain CT Perfusion Evaluation in Transient Ischaemic Attack: A Cross-sectional Study from a Tertiary Care Centre, New Delhi, India Journal of Clinical and Diagnostic Research cerebrovascular accident computed tomography perfusion postischaemic hyperperfusion stroke |
| title | Whole Brain CT Perfusion Evaluation in Transient Ischaemic Attack: A Cross-sectional Study from a Tertiary Care Centre, New Delhi, India |
| title_full | Whole Brain CT Perfusion Evaluation in Transient Ischaemic Attack: A Cross-sectional Study from a Tertiary Care Centre, New Delhi, India |
| title_fullStr | Whole Brain CT Perfusion Evaluation in Transient Ischaemic Attack: A Cross-sectional Study from a Tertiary Care Centre, New Delhi, India |
| title_full_unstemmed | Whole Brain CT Perfusion Evaluation in Transient Ischaemic Attack: A Cross-sectional Study from a Tertiary Care Centre, New Delhi, India |
| title_short | Whole Brain CT Perfusion Evaluation in Transient Ischaemic Attack: A Cross-sectional Study from a Tertiary Care Centre, New Delhi, India |
| title_sort | whole brain ct perfusion evaluation in transient ischaemic attack a cross sectional study from a tertiary care centre new delhi india |
| topic | cerebrovascular accident computed tomography perfusion postischaemic hyperperfusion stroke |
| url | https://jcdr.net/articles/PDF/15994/50889_CE(Ra1)_F(SS)_PF1(SC_KM)_PFA(SC_KM)_PN(KM).pdf |
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