Exploring candidate biomarkers for rheumatoid arthritis through cardiovascular and cardiometabolic serum proteome profiling

Exploring candidate biomarkers for rheumatoid arthritis through cardiovascular and cardiometabolic serum proteome profiling

IntroductionRA patients are at higher risk of cardiovascular disease, influenced by therapies. Studying their cardiovascular and cardiometabolic proteome can unveil biomarkers and insights into related biological pathways.MethodsThis study included two cohorts of RA patients: newly diagnosed individ...

Full description

Bibliographic Details
Main Authors:	Laura Cuesta-López, Alejandro Escudero-Contreras, Yas Hanaee, Carlos Pérez-Sánchez, Miriam Ruiz-Ponce, Julio Manuel Martínez-Moreno, Eva Pérez-Pampin, Antonio González, Chamaida Plasencia-Rodriguez, Ana Martínez-Feito, Alejandro Balsa, Clementina López-Medina, Lourdes Ladehesa-Pineda, Marta Rojas-Giménez, Rafaela Ortega-Castro, Jerusalem Calvo-Gutiérrez, Chary López-Pedrera, Eduardo Collantes-Estévez, Iván Arias-de la Rosa, Nuria Barbarroja
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Series:	Frontiers in Immunology
Subjects:	rheumatoid arthritis methotrexate tofacitinib biomarkers proximity extension assay (PEA) Olink
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1333995/full

Similar Items

Characterization of the inflammatory proteome of synovial fluid from patients with psoriatic arthritis: Potential treatment targets
by: Nuria Barbarroja, et al.
Published: (2023-03-01)

Nonalcoholic fatty liver disease in inflammatory arthritis: Relationship with cardiovascular risk
by: Nuria Barbarroja, et al.
Published: (2022-09-01)

New Biomarkers for Atherothrombosis in Antiphospholipid Syndrome: Genomics and Epigenetics Approaches
by: Chary Lopez-Pedrera, et al.
Published: (2019-04-01)

Effects of Biological Therapies on Molecular Features of Rheumatoid Arthritis
by: Chary Lopez-Pedrera, et al.
Published: (2020-11-01)

Methotrexate Reduces the Probability of Discontinuation of TNF Inhibitors in Seropositive Patients With Rheumatoid Arthritis. A Real-World Data Analysis
by: Borja Hernández-Breijo, et al.
Published: (2021-06-01)

Differences and similarities in clinical and functional responses among patients receiving tofacitinib monotherapy, tofacitinib plus methotrexate, and adalimumab plus methotrexate: a post hoc analysis of data from ORAL Strategy
by: Tsutomu Takeuchi, et al.
Published: (2021-08-01)

Joint-level responses to tofacitinib and methotrexate: a post hoc analysis of data from ORAL Start
by: Adrian Ciurea, et al.
Published: (2023-09-01)

Effect of food intake on 92 oncological biomarkers by the Proseek Oncology II panel
by: Magnus Dencker, et al.
Published: (2019-04-01)

Editorial: Clinical management, pathogenesis and biomarkers of cardiovascular disease associated with systemic autoimmune disorders
by: Carlos Perez-Sanchez, et al.
Published: (2022-11-01)

Inflammation and Neurodegeneration in Glaucoma: Isolated Eye Disease or a Part of a Systemic Disorder? - Serum Proteomic Analysis
by: Okruszko MA, et al.
Published: (2024-02-01)

Different Therapeutic Response to Anti-TNF Drugs in Patients with Axial Spondyloarthritis Depending on Their Clinical Profile: An Unsupervised Cluster Analysis
by: Carmen Priego-Pérez, et al.
Published: (2024-03-01)

Therapeutic Potential and Immunomodulatory Role of Coenzyme Q<sub>10</sub> and Its Analogues in Systemic Autoimmune Diseases
by: Chary López-Pedrera, et al.
Published: (2021-04-01)

Derivation of a Protein Risk Score for Cardiovascular Disease Among a Multiracial and Multiethnic HIV+ Cohort
by: Sandra E. Safo, et al.
Published: (2023-07-01)

Clinical Utility of microRNAs in Exhaled Breath Condensate as Biomarkers for Lung Cancer
by: Carlos Pérez-Sánchez, et al.
Published: (2021-02-01)

Potential Role and Impact of Peripheral Blood Mononuclear Cells in Radiographic Axial Spondyloarthritis-Associated Endothelial Dysfunction
by: Patricia Ruiz-Limon, et al.
Published: (2021-06-01)

Inflammatory related plasma proteins involved in acute preschool wheeze
by: Idun Holmdahl, et al.
Published: (2023-11-01)

Olink proteomics profiling platform reveals non-invasive inflammatory related protein biomarkers in autism spectrum disorder
by: Xiao-Hong Bao, et al.
Published: (2023-05-01)

Plasma protein profiling analysis in patients with atrial fibrillation before and after three different ablation techniques
by: Menglu Lin, et al.
Published: (2023-01-01)

Decoding clinical and molecular pathways of liver dysfunction in Psoriatic Arthritis: Impact of cumulative methotrexate doses
by: M. Ruiz-Ponce, et al.
Published: (2023-12-01)

Vitreous Olink proteomics reveals inflammatory biomarkers for diagnosis and prognosis of traumatic proliferative vitreoretinopathy
by: Haixia Guo, et al.
Published: (2024-02-01)

Identification of Plasma Inflammatory Markers of Adolescent Depression Using the Olink Proteomics Platform
by: Yang L, et al.
Published: (2023-10-01)

Plasma Kidney Injury Molecule-1 in Systemic Lupus Erythematosus: Discordance Between ELISA and Proximity Extension Assay
by: Insa M. Schmidt, MD, MPH, et al.
Published: (2022-08-01)

Technical Performance Evaluation of Olink Proximity Extension Assay for Blood-Based Biomarker Discovery in Longitudinal Studies of Alzheimer's Disease
by: Becky C. Carlyle, et al.
Published: (2022-06-01)

Efficacy and safety of tofacitinib combined with methotrexate in the treatment of rheumatoid arthritis: A systematic review and meta-analysis
by: Yan Gao, et al.
Published: (2023-05-01)

Cardiovascular risk factors in psoriatic disease: psoriasis psoriatic arthritis
by: Nuria Barbarroja, et al.
Published: (2019-10-01)

Pathogenic mechanisms involving the interplay between adipose tissue and auto-antibodies in rheumatoid arthritis
by: Iván Arias-de la Rosa, et al.
Published: (2022-09-01)

Enhanced NETosis generation in radiographic axial spondyloarthritis: utility as biomarker for disease activity and anti-TNF-α therapy effectiveness
by: Patricia Ruiz-Limon, et al.
Published: (2020-04-01)

Tofacitinib: Revisión
by: Carlos Ríos Acosta, et al.
Published: (2016-12-01)

Inflammation proteomics datasets in the ALSPAC cohort [version 2; peer review: 2 approved]
by: Matthew Suderman, et al.
Published: (2024-02-01)

Blood-Based Proteomic Profiling Identifies Potential Biomarker Candidates and Pathogenic Pathways in Dementia
by: Hanan Ehtewish, et al.
Published: (2023-05-01)

Uncovering a neurological protein signature for severe COVID-19
by: Omar El-Agnaf, et al.
Published: (2023-06-01)

Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers
by: Helen He, et al.
Published: (2020-08-01)

Plasma perfluoroalkyls are associated with decreased levels of proteomic inflammatory markers in a cross-sectional study of an elderly population
by: S. Salihovic, et al.
Published: (2020-12-01)

Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis
by: Sandra Pérez-Baos, et al.
Published: (2019-01-01)

Genetic Polymorphisms of GGH and ABCC2 Are Associated with Methotrexate Intolerance in Patients with Rheumatoid Arthritis
by: Alejandro Escudero-Contreras, et al.
Published: (2021-09-01)

Complement component 3 as biomarker of disease activity and cardiometabolic risk factor in rheumatoid arthritis and spondyloarthritis
by: Iván Arias de la Rosa, et al.
Published: (2020-10-01)

Progression from high insulin resistance to type 2 diabetes does not entail additional visceral adipose tissue inflammation.
by: Nuria Barbarroja, et al.
Published: (2012-01-01)

Treatment of STING‐associated vasculopathy with onset in infancy
by: Xiaozhen Zhao, et al.
Published: (2023-06-01)

Efficacy of tofacitinib on rheumatoid arthritis: A retrospective single-center cohort study
by: Yuhui Qi, et al.
Published: (2023-09-01)

Successful treatment of refractory tumor necrosis factor inhibitor-induced palmoplantar pustulosis with tofacitinib: Report of case
by: Yixin Ally Wang, BA, et al.
Published: (2020-02-01)