Major and minor subgroup profile of blood in patients receiving multiple transfusions and donors
OBJECTIVE: It was aimed to profile the blood subgroups of our region and to reveal the prevalence of auto/alloimmune sensitization in patients who had to undergo multiple erythrocyte transfusions and to establish the sensitization profile by screening major and minor subgroups. MATERIALS AND METHODS...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Asian Journal of Transfusion Science |
| Subjects: | |
| Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=219;epage=223;aulast=Orhan |
| _version_ | 1828166777957253120 |
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| author | Mehmet Fatih Orhan Merve Pilavci Adigül Mustafa Altindiş Mehmet Köroğlu |
| author_facet | Mehmet Fatih Orhan Merve Pilavci Adigül Mustafa Altindiş Mehmet Köroğlu |
| author_sort | Mehmet Fatih Orhan |
| collection | DOAJ |
| description | OBJECTIVE: It was aimed to profile the blood subgroups of our region and to reveal the prevalence of auto/alloimmune sensitization in patients who had to undergo multiple erythrocyte transfusions and to establish the sensitization profile by screening major and minor subgroups.
MATERIALS AND METHODS: In this study, the distribution of ABO and Rh system major subgroups was studied in 100 donor blood. As the patient group, 50 patients who received three or more red blood cell transfusions were included. In addition to this group, Kell, Lewis, Duffy blood group systems were studied.
RESULTS: According to the ABO system, 35% of the donors were in O, 33% in A, 17% in AB, and 15% in B. According to the Rh system, 75% is Dvi positive. Rh system is 99% e positive and 33% E positive in major subgroups and Kell1 positivity is 8%. In the patient group, 22% D(-) was determined compared to Rh blood group. Among the major subgroups of Rh, C was 68%, E was 14%, c was 76%, and e positivity was found to be 100%. The Kell1 negativity rate is 96%. The highest negativity was found in 86% Lea antigen in Lewis system, in 36% S antigen in MNS system, 34% Fyb antigen in Duffy system, and 24% Jka antigen in Kidd system. When inappropriate blood is given for any antigen, a double population is formed. The double negativities we detected in our study occurred as follows according to blood group systems: E 18%, C 12%, c 8%, Cw 2%, Kell 1 2%, M 8%, N 4%, S 18%, s 6%, Fya 8%, Jka 6%, Jkb 22%. Indirect Agglutination Test (IAT) was negative in all patients.
CONCLUSION: IAT negativity in all patient groups suggests that we do not develop alloimmunization, but the high rates of double population suggest a high risk of alloimmunization. |
| first_indexed | 2024-04-12T02:07:09Z |
| format | Article |
| id | doaj.art-9317b852dac44a199281de6a7337dbfa |
| institution | Directory Open Access Journal |
| issn | 0973-6247 1998-3565 |
| language | English |
| last_indexed | 2024-04-12T02:07:09Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Transfusion Science |
| spelling | doaj.art-9317b852dac44a199281de6a7337dbfa2022-12-22T03:52:30ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652022-01-0116221922310.4103/ajts.ajts_17_21Major and minor subgroup profile of blood in patients receiving multiple transfusions and donorsMehmet Fatih OrhanMerve Pilavci AdigülMustafa AltindişMehmet KöroğluOBJECTIVE: It was aimed to profile the blood subgroups of our region and to reveal the prevalence of auto/alloimmune sensitization in patients who had to undergo multiple erythrocyte transfusions and to establish the sensitization profile by screening major and minor subgroups. MATERIALS AND METHODS: In this study, the distribution of ABO and Rh system major subgroups was studied in 100 donor blood. As the patient group, 50 patients who received three or more red blood cell transfusions were included. In addition to this group, Kell, Lewis, Duffy blood group systems were studied. RESULTS: According to the ABO system, 35% of the donors were in O, 33% in A, 17% in AB, and 15% in B. According to the Rh system, 75% is Dvi positive. Rh system is 99% e positive and 33% E positive in major subgroups and Kell1 positivity is 8%. In the patient group, 22% D(-) was determined compared to Rh blood group. Among the major subgroups of Rh, C was 68%, E was 14%, c was 76%, and e positivity was found to be 100%. The Kell1 negativity rate is 96%. The highest negativity was found in 86% Lea antigen in Lewis system, in 36% S antigen in MNS system, 34% Fyb antigen in Duffy system, and 24% Jka antigen in Kidd system. When inappropriate blood is given for any antigen, a double population is formed. The double negativities we detected in our study occurred as follows according to blood group systems: E 18%, C 12%, c 8%, Cw 2%, Kell 1 2%, M 8%, N 4%, S 18%, s 6%, Fya 8%, Jka 6%, Jkb 22%. Indirect Agglutination Test (IAT) was negative in all patients. CONCLUSION: IAT negativity in all patient groups suggests that we do not develop alloimmunization, but the high rates of double population suggest a high risk of alloimmunization.http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=219;epage=223;aulast=Orhanalloimmunizationdonorred blood cell antigenssafe bloodtransfusion medicine |
| spellingShingle | Mehmet Fatih Orhan Merve Pilavci Adigül Mustafa Altindiş Mehmet Köroğlu Major and minor subgroup profile of blood in patients receiving multiple transfusions and donors Asian Journal of Transfusion Science alloimmunization donor red blood cell antigens safe blood transfusion medicine |
| title | Major and minor subgroup profile of blood in patients receiving multiple transfusions and donors |
| title_full | Major and minor subgroup profile of blood in patients receiving multiple transfusions and donors |
| title_fullStr | Major and minor subgroup profile of blood in patients receiving multiple transfusions and donors |
| title_full_unstemmed | Major and minor subgroup profile of blood in patients receiving multiple transfusions and donors |
| title_short | Major and minor subgroup profile of blood in patients receiving multiple transfusions and donors |
| title_sort | major and minor subgroup profile of blood in patients receiving multiple transfusions and donors |
| topic | alloimmunization donor red blood cell antigens safe blood transfusion medicine |
| url | http://www.ajts.org/article.asp?issn=0973-6247;year=2022;volume=16;issue=2;spage=219;epage=223;aulast=Orhan |
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