LncRNA HOTAIR-mediated Wnt/β-catenin network modeling to predict and validate therapeutic targets for cartilage damage

LncRNA HOTAIR-mediated Wnt/β-catenin network modeling to predict and validate therapeutic targets for cartilage damage

Abstract Background Cartilage damage is a crucial feature involved in several pathological conditions characterized by joint disorders, such as osteoarthritis and rheumatoid arthritis. Accumulated evidences showed that Wnt/β-catenin pathway plays a role in the pathogenesis of cartilage damage. In ad...

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Bibliographic Details
Main Authors: Wei Zhou, Xiaojuan He, Ziyi Chen, Danping Fan, Yonghua Wang, Hui Feng, Ge Zhang, Aiping Lu, Lianbo Xiao
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Bioinformatics
Subjects:
LncRNA HOTAIR
Dynamic network
Therapeutic targets
Dynamic mechanism
Cartilage damage
Online Access:http://link.springer.com/article/10.1186/s12859-019-2981-4

Internet

http://link.springer.com/article/10.1186/s12859-019-2981-4

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