A comparison of altered white matter microstructure in youth born with congenital heart disease or born preterm
IntroductionAlterations to white matter microstructure as detected by diffusion tensor imaging have been documented in both individuals born with congenital heart disease (CHD) and individuals born preterm. However, it remains unclear if these disturbances are the consequence of similar underlying m...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1167026/full |
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| author | Kaitlyn Easson Kaitlyn Easson May Khairy Charles V. Rohlicek Christine Saint-Martin Guillaume Gilbert Kim-Anh Nguyen Thuy Mai Luu Élise Couture Anne-Monique Nuyt Pia Wintermark Sean C. L. Deoni Maxime Descoteaux Marie Brossard-Racine Marie Brossard-Racine Marie Brossard-Racine Marie Brossard-Racine |
| author_facet | Kaitlyn Easson Kaitlyn Easson May Khairy Charles V. Rohlicek Christine Saint-Martin Guillaume Gilbert Kim-Anh Nguyen Thuy Mai Luu Élise Couture Anne-Monique Nuyt Pia Wintermark Sean C. L. Deoni Maxime Descoteaux Marie Brossard-Racine Marie Brossard-Racine Marie Brossard-Racine Marie Brossard-Racine |
| author_sort | Kaitlyn Easson |
| collection | DOAJ |
| description | IntroductionAlterations to white matter microstructure as detected by diffusion tensor imaging have been documented in both individuals born with congenital heart disease (CHD) and individuals born preterm. However, it remains unclear if these disturbances are the consequence of similar underlying microstructural disruptions. This study used multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) and neurite orientation dispersion and density imaging (NODDI) to characterize and compare alterations to three specific microstructural elements of white matter – myelination, axon density, and axon orientation – in youth born with CHD or born preterm.MethodsParticipants aged 16 to 26 years with operated CHD or born ≤33 weeks gestational age and a group of healthy peers of the same age underwent a brain MRI including mcDESPOT and high angular resolution diffusion imaging acquisitions. Using tractometry, average values of myelin water fraction (MWF), neurite density index (NDI), and orientation dispersion index (ODI) were first calculated and compared between groups for 30 white matter bundles. Afterwards, bundle profiling was performed to further characterize the topology of the detected microstructural alterations.ResultsThe CHD and preterm groups both presented with widespread bundles and bundle segments with lower MWF, accompanied by some occurrences of lower NDI, relative to controls. While there were no differences in ODI between the CHD and control groups, the preterm group presented with both higher and lower ODI compared to the control group and lower ODI compared to the CHD group.DiscussionWhile youth born with CHD or born preterm both presented with apparent deficits in white matter myelination and axon density, youth born preterm presented with a unique profile of altered axonal organization. Future longitudinal studies should aim to better understand the emergence of these common and distinct microstructural alterations, which could orient the development of novel therapeutic approaches. |
| first_indexed | 2024-04-09T13:14:47Z |
| format | Article |
| id | doaj.art-931809a7bc8e48d6b1e207979a9000a5 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T13:14:47Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-931809a7bc8e48d6b1e207979a9000a52023-05-12T04:30:33ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-05-011410.3389/fneur.2023.11670261167026A comparison of altered white matter microstructure in youth born with congenital heart disease or born pretermKaitlyn Easson0Kaitlyn Easson1May Khairy2Charles V. Rohlicek3Christine Saint-Martin4Guillaume Gilbert5Kim-Anh Nguyen6Thuy Mai Luu7Élise Couture8Anne-Monique Nuyt9Pia Wintermark10Sean C. L. Deoni11Maxime Descoteaux12Marie Brossard-Racine13Marie Brossard-Racine14Marie Brossard-Racine15Marie Brossard-Racine16Advances in Brain and Child Development (ABCD) Research Laboratory, Research Institute of the McGill University Health Centre, Montreal, QC, CanadaDepartment of Neurology and Neurosurgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, CanadaDivision of Neonatology, Department of Pediatrics, Montreal Children’s Hospital, Montreal, QC, CanadaDivision of Cardiology, Department of Pediatrics, Montreal Children’s Hospital, Montreal, QC, CanadaDepartment of Medical Imaging, Division of Pediatric Radiology, Montreal Children’s Hospital, Montreal, QC, CanadaMR Clinical Science, Philips Healthcare, Mississauga, ON, CanadaDivision of Neonatology, Department of Pediatrics, Jewish General Hospital, Montreal, QC, CanadaDepartment of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, CanadaDivision of Neonatology, Department of Pediatrics, Montreal Children’s Hospital, Montreal, QC, CanadaDepartment of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, CanadaDivision of Neonatology, Department of Pediatrics, Montreal Children’s Hospital, Montreal, QC, CanadaAdvanced Baby Imaging Lab, Brown University, Providence, RI, United States0Sherbrooke Connectivity Imaging Laboratory (SCIL), Université de Sherbrooke, Sherbrooke, QC, CanadaAdvances in Brain and Child Development (ABCD) Research Laboratory, Research Institute of the McGill University Health Centre, Montreal, QC, CanadaDepartment of Neurology and Neurosurgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, CanadaDivision of Neonatology, Department of Pediatrics, Montreal Children’s Hospital, Montreal, QC, Canada1School of Physical and Occupational Therapy, McGill University, Montreal, QC, CanadaIntroductionAlterations to white matter microstructure as detected by diffusion tensor imaging have been documented in both individuals born with congenital heart disease (CHD) and individuals born preterm. However, it remains unclear if these disturbances are the consequence of similar underlying microstructural disruptions. This study used multicomponent driven equilibrium single pulse observation of T1 and T2 (mcDESPOT) and neurite orientation dispersion and density imaging (NODDI) to characterize and compare alterations to three specific microstructural elements of white matter – myelination, axon density, and axon orientation – in youth born with CHD or born preterm.MethodsParticipants aged 16 to 26 years with operated CHD or born ≤33 weeks gestational age and a group of healthy peers of the same age underwent a brain MRI including mcDESPOT and high angular resolution diffusion imaging acquisitions. Using tractometry, average values of myelin water fraction (MWF), neurite density index (NDI), and orientation dispersion index (ODI) were first calculated and compared between groups for 30 white matter bundles. Afterwards, bundle profiling was performed to further characterize the topology of the detected microstructural alterations.ResultsThe CHD and preterm groups both presented with widespread bundles and bundle segments with lower MWF, accompanied by some occurrences of lower NDI, relative to controls. While there were no differences in ODI between the CHD and control groups, the preterm group presented with both higher and lower ODI compared to the control group and lower ODI compared to the CHD group.DiscussionWhile youth born with CHD or born preterm both presented with apparent deficits in white matter myelination and axon density, youth born preterm presented with a unique profile of altered axonal organization. Future longitudinal studies should aim to better understand the emergence of these common and distinct microstructural alterations, which could orient the development of novel therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fneur.2023.1167026/fullcongenital heart diseasepretermwhite matter microstructureneurite orientation dispersion and density imagingmulticomponent driven equilibrium single pulse observation of T1 and T2 |
| spellingShingle | Kaitlyn Easson Kaitlyn Easson May Khairy Charles V. Rohlicek Christine Saint-Martin Guillaume Gilbert Kim-Anh Nguyen Thuy Mai Luu Élise Couture Anne-Monique Nuyt Pia Wintermark Sean C. L. Deoni Maxime Descoteaux Marie Brossard-Racine Marie Brossard-Racine Marie Brossard-Racine Marie Brossard-Racine A comparison of altered white matter microstructure in youth born with congenital heart disease or born preterm Frontiers in Neurology congenital heart disease preterm white matter microstructure neurite orientation dispersion and density imaging multicomponent driven equilibrium single pulse observation of T1 and T2 |
| title | A comparison of altered white matter microstructure in youth born with congenital heart disease or born preterm |
| title_full | A comparison of altered white matter microstructure in youth born with congenital heart disease or born preterm |
| title_fullStr | A comparison of altered white matter microstructure in youth born with congenital heart disease or born preterm |
| title_full_unstemmed | A comparison of altered white matter microstructure in youth born with congenital heart disease or born preterm |
| title_short | A comparison of altered white matter microstructure in youth born with congenital heart disease or born preterm |
| title_sort | comparison of altered white matter microstructure in youth born with congenital heart disease or born preterm |
| topic | congenital heart disease preterm white matter microstructure neurite orientation dispersion and density imaging multicomponent driven equilibrium single pulse observation of T1 and T2 |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1167026/full |
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