Differences between Survival Rates and Patterns of Failure of Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma Who Received Single-Fraction Stereotactic Body Radiotherapy
We investigated the survival and patterns of failure in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) in early stage non-small cell lung cancer (NSCLC) treated with single-fraction stereotactic body radiation therapy (SF-SBRT) of 27–34 Gray. A single-institution retrospective review of pati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/16/4/755 |
| _version_ | 1797298704560947200 |
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| author | Tyler V. Schrand Austin J. Iovoli Neil D. Almeida Han Yu Nadia Malik Mark Farrugia Anurag K. Singh |
| author_facet | Tyler V. Schrand Austin J. Iovoli Neil D. Almeida Han Yu Nadia Malik Mark Farrugia Anurag K. Singh |
| author_sort | Tyler V. Schrand |
| collection | DOAJ |
| description | We investigated the survival and patterns of failure in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) in early stage non-small cell lung cancer (NSCLC) treated with single-fraction stereotactic body radiation therapy (SF-SBRT) of 27–34 Gray. A single-institution retrospective review of patients with biopsy-proven early stage ADC or SCC undergoing definitive SF-SBRT between September 2008 and February 2023 was performed. The primary outcomes were overall survival (OS) and disease-free survival (DFS). The secondary outcomes included local failure (LF), nodal failure (NF), and distant failure (DF). Of 292 eligible patients 174 had adenocarcinoma and 118 had squamous cell carcinoma. There was no significant change in any outcome except distant failure. Patients with ADC were significantly more likely to experience distant failure than patients with SCC (<i>p</i> = 0.0081). In conclusion, while SF-SBRT produced similar LF, NF, DFS, and OS, the higher rate of distant failure in ADC patients suggests that ongoing trials of SBRT and systemic therapy combinations should report their outcomes by histology. |
| first_indexed | 2024-03-07T22:38:49Z |
| format | Article |
| id | doaj.art-931a22fa7d244025ac4d9b7cb70b97b6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-07T22:38:49Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-931a22fa7d244025ac4d9b7cb70b97b62024-02-23T15:10:47ZengMDPI AGCancers2072-66942024-02-0116475510.3390/cancers16040755Differences between Survival Rates and Patterns of Failure of Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma Who Received Single-Fraction Stereotactic Body RadiotherapyTyler V. Schrand0Austin J. Iovoli1Neil D. Almeida2Han Yu3Nadia Malik4Mark Farrugia5Anurag K. Singh6Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USADepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USADepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USADepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USADepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USADepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USADepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USAWe investigated the survival and patterns of failure in adenocarcinoma (ADC) and squamous cell carcinoma (SCC) in early stage non-small cell lung cancer (NSCLC) treated with single-fraction stereotactic body radiation therapy (SF-SBRT) of 27–34 Gray. A single-institution retrospective review of patients with biopsy-proven early stage ADC or SCC undergoing definitive SF-SBRT between September 2008 and February 2023 was performed. The primary outcomes were overall survival (OS) and disease-free survival (DFS). The secondary outcomes included local failure (LF), nodal failure (NF), and distant failure (DF). Of 292 eligible patients 174 had adenocarcinoma and 118 had squamous cell carcinoma. There was no significant change in any outcome except distant failure. Patients with ADC were significantly more likely to experience distant failure than patients with SCC (<i>p</i> = 0.0081). In conclusion, while SF-SBRT produced similar LF, NF, DFS, and OS, the higher rate of distant failure in ADC patients suggests that ongoing trials of SBRT and systemic therapy combinations should report their outcomes by histology.https://www.mdpi.com/2072-6694/16/4/755SBRTlung cancerNSCLCradiotherapyradiation |
| spellingShingle | Tyler V. Schrand Austin J. Iovoli Neil D. Almeida Han Yu Nadia Malik Mark Farrugia Anurag K. Singh Differences between Survival Rates and Patterns of Failure of Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma Who Received Single-Fraction Stereotactic Body Radiotherapy Cancers SBRT lung cancer NSCLC radiotherapy radiation |
| title | Differences between Survival Rates and Patterns of Failure of Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma Who Received Single-Fraction Stereotactic Body Radiotherapy |
| title_full | Differences between Survival Rates and Patterns of Failure of Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma Who Received Single-Fraction Stereotactic Body Radiotherapy |
| title_fullStr | Differences between Survival Rates and Patterns of Failure of Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma Who Received Single-Fraction Stereotactic Body Radiotherapy |
| title_full_unstemmed | Differences between Survival Rates and Patterns of Failure of Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma Who Received Single-Fraction Stereotactic Body Radiotherapy |
| title_short | Differences between Survival Rates and Patterns of Failure of Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma Who Received Single-Fraction Stereotactic Body Radiotherapy |
| title_sort | differences between survival rates and patterns of failure of patients with lung adenocarcinoma and squamous cell carcinoma who received single fraction stereotactic body radiotherapy |
| topic | SBRT lung cancer NSCLC radiotherapy radiation |
| url | https://www.mdpi.com/2072-6694/16/4/755 |
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