Activity-dependent constraints on catecholamine signaling
Summary: Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and condition...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723015784 |
| _version_ | 1827583847981645824 |
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| author | Li Li Akshay N. Rana Esther M. Li Jiesi Feng Yulong Li Michael R. Bruchas |
| author_facet | Li Li Akshay N. Rana Esther M. Li Jiesi Feng Yulong Li Michael R. Bruchas |
| author_sort | Li Li |
| collection | DOAJ |
| description | Summary: Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity in vivo depleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together, these findings provide a more complete understanding of the inverted-U relationship, offering insights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling. |
| first_indexed | 2024-03-08T23:12:39Z |
| format | Article |
| id | doaj.art-931a469d7461421e8327d7fdce776273 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-08T23:12:39Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-931a469d7461421e8327d7fdce7762732023-12-15T07:23:54ZengElsevierCell Reports2211-12472023-12-014212113566Activity-dependent constraints on catecholamine signalingLi Li0Akshay N. Rana1Esther M. Li2Jiesi Feng3Yulong Li4Michael R. Bruchas5Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Seattle Children’s Research Institute, Seattle, WA 98101, USA; Corresponding authorDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USADepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Psychology, University of Washington, Seattle, WA 98105, USAState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, ChinaState Key Laboratory of Membrane Biology, School of Life Sciences, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, New Cornerstone Science Laboratory, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, ChinaDepartment of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98195, USA; Center for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195, USA; Department of Bioengineering, University of Washington, Seattle, WA 98105, USA; Department of Pharmacology, University of Washington, Seattle, WA 98195, USA; Corresponding authorSummary: Catecholamine signaling is thought to modulate cognition in an inverted-U relationship, but the mechanisms are unclear. We measured norepinephrine and dopamine release, postsynaptic calcium responses, and interactions between tonic and phasic firing modes under various stimuli and conditions. High tonic activity in vivo depleted catecholamine stores, desensitized postsynaptic responses, and decreased phasic transmission. Together, these findings provide a more complete understanding of the inverted-U relationship, offering insights into psychiatric disorders and neurodegenerative diseases with impaired catecholamine signaling.http://www.sciencedirect.com/science/article/pii/S2211124723015784CP: Neuroscience |
| spellingShingle | Li Li Akshay N. Rana Esther M. Li Jiesi Feng Yulong Li Michael R. Bruchas Activity-dependent constraints on catecholamine signaling Cell Reports CP: Neuroscience |
| title | Activity-dependent constraints on catecholamine signaling |
| title_full | Activity-dependent constraints on catecholamine signaling |
| title_fullStr | Activity-dependent constraints on catecholamine signaling |
| title_full_unstemmed | Activity-dependent constraints on catecholamine signaling |
| title_short | Activity-dependent constraints on catecholamine signaling |
| title_sort | activity dependent constraints on catecholamine signaling |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723015784 |
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