Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing
Summary: Internal brain states affect sensory perception, cognition, and learning. Many neocortical areas exhibit changes in the pattern and synchrony of neuronal activity during quiet versus active behaviors. Active behaviors are typically associated with desynchronized cortical dynamics. Increased...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-12-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124714009590 |
| _version_ | 1818916559606775808 |
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| author | Emmanuel Eggermann Yves Kremer Sylvain Crochet Carl C.H. Petersen |
| author_facet | Emmanuel Eggermann Yves Kremer Sylvain Crochet Carl C.H. Petersen |
| author_sort | Emmanuel Eggermann |
| collection | DOAJ |
| description | Summary: Internal brain states affect sensory perception, cognition, and learning. Many neocortical areas exhibit changes in the pattern and synchrony of neuronal activity during quiet versus active behaviors. Active behaviors are typically associated with desynchronized cortical dynamics. Increased thalamic firing contributes importantly to desynchronize mouse barrel cortex during active whisker sensing. However, a whisking-related cortical state change persists after thalamic inactivation, which is mediated at least in part by acetylcholine, as we show here by using whole-cell recordings, local pharmacology, axonal calcium imaging, and optogenetic stimulation. During whisking, we find prominent cholinergic signals in the barrel cortex, which suppress spontaneous cortical activity. The desynchronized state of barrel cortex during whisking is therefore driven by at least two distinct signals with opposing functions: increased thalamic activity driving glutamatergic excitation of the cortex and increased cholinergic input suppressing spontaneous cortical activity. : Eggermann et al. now find that the desynchronized state of the barrel cortex during active whisker sensing is accompanied by increased cholinergic input, which suppresses slow spontaneous cortical activity in excitatory layer 2/3 barrel cortex neurons. |
| first_indexed | 2024-12-20T00:20:06Z |
| format | Article |
| id | doaj.art-931b3fbd80d04fb095753ef42b5bc0eb |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-20T00:20:06Z |
| publishDate | 2014-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-931b3fbd80d04fb095753ef42b5bc0eb2022-12-21T20:00:13ZengElsevierCell Reports2211-12472014-12-019516541660Cholinergic Signals in Mouse Barrel Cortex during Active Whisker SensingEmmanuel Eggermann0Yves Kremer1Sylvain Crochet2Carl C.H. Petersen3Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, SwitzerlandLaboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, SwitzerlandLaboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland; Corresponding authorLaboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland; Corresponding authorSummary: Internal brain states affect sensory perception, cognition, and learning. Many neocortical areas exhibit changes in the pattern and synchrony of neuronal activity during quiet versus active behaviors. Active behaviors are typically associated with desynchronized cortical dynamics. Increased thalamic firing contributes importantly to desynchronize mouse barrel cortex during active whisker sensing. However, a whisking-related cortical state change persists after thalamic inactivation, which is mediated at least in part by acetylcholine, as we show here by using whole-cell recordings, local pharmacology, axonal calcium imaging, and optogenetic stimulation. During whisking, we find prominent cholinergic signals in the barrel cortex, which suppress spontaneous cortical activity. The desynchronized state of barrel cortex during whisking is therefore driven by at least two distinct signals with opposing functions: increased thalamic activity driving glutamatergic excitation of the cortex and increased cholinergic input suppressing spontaneous cortical activity. : Eggermann et al. now find that the desynchronized state of the barrel cortex during active whisker sensing is accompanied by increased cholinergic input, which suppresses slow spontaneous cortical activity in excitatory layer 2/3 barrel cortex neurons.http://www.sciencedirect.com/science/article/pii/S2211124714009590 |
| spellingShingle | Emmanuel Eggermann Yves Kremer Sylvain Crochet Carl C.H. Petersen Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing Cell Reports |
| title | Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing |
| title_full | Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing |
| title_fullStr | Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing |
| title_full_unstemmed | Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing |
| title_short | Cholinergic Signals in Mouse Barrel Cortex during Active Whisker Sensing |
| title_sort | cholinergic signals in mouse barrel cortex during active whisker sensing |
| url | http://www.sciencedirect.com/science/article/pii/S2211124714009590 |
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