Three-dimensional ultrasonography measurement of fetal nasal bone length during the midtrimester in Taiwanese women
Objective: To evaluate the normal range of the fetal nasal bone length (NBL) in Taiwanese women using three-dimensional (3D) ultrasound, and compare the NBL of normal fetuses with Down syndrome to determine its significance in screening for trisomy 21. Materials and Methods: A total of 102 consecuti...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-09-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455912001209 |
| _version_ | 1818453282873409536 |
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| author | Pei-Yin Yang Joung-Liang Wu Guang-Perng Yeh Charles Tsung-Che Hsieh |
| author_facet | Pei-Yin Yang Joung-Liang Wu Guang-Perng Yeh Charles Tsung-Che Hsieh |
| author_sort | Pei-Yin Yang |
| collection | DOAJ |
| description | Objective: To evaluate the normal range of the fetal nasal bone length (NBL) in Taiwanese women using three-dimensional (3D) ultrasound, and compare the NBL of normal fetuses with Down syndrome to determine its significance in screening for trisomy 21.
Materials and Methods: A total of 102 consecutive fetuses and another 7 fetuses with trisomy 21, determined by karyotyping at 15–22 weeks' gestation, were evaluated with 3D ultrasound before amniocentesis at Changhua Christian Hospital between November 2003 and April 2004.
Results: The normal range for NBL in the second trimester in the Taiwanese population was investigated, and a linear relationship with gestational age was noted. The NBL increased with advancing gestational age (NBL in cm=0.0264×gestational age in weeks –0.042 (R2=0.2416). The median of the biparietal diameter/nasal bone length ratio had a stable value which tended to change minimally between 15 and 22 weeks of gestation. Chromosomally normal fetuses had statistically longer nasal bones than fetuses with Down syndrome (p=0.014).
Conclusion: We present a reference range for 3D ultrasound measurement of the fetal NBL. A short nasal bone at 15 to 22 weeks is associated with a high risk of trisomy 21. |
| first_indexed | 2024-12-14T21:36:31Z |
| format | Article |
| id | doaj.art-931d1d97cb374d8f881b0989265cb27e |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-14T21:36:31Z |
| publishDate | 2012-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-931d1d97cb374d8f881b0989265cb27e2022-12-21T22:46:34ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592012-09-0151335435810.1016/j.tjog.2012.07.006Three-dimensional ultrasonography measurement of fetal nasal bone length during the midtrimester in Taiwanese womenPei-Yin YangJoung-Liang WuGuang-Perng YehCharles Tsung-Che HsiehObjective: To evaluate the normal range of the fetal nasal bone length (NBL) in Taiwanese women using three-dimensional (3D) ultrasound, and compare the NBL of normal fetuses with Down syndrome to determine its significance in screening for trisomy 21. Materials and Methods: A total of 102 consecutive fetuses and another 7 fetuses with trisomy 21, determined by karyotyping at 15–22 weeks' gestation, were evaluated with 3D ultrasound before amniocentesis at Changhua Christian Hospital between November 2003 and April 2004. Results: The normal range for NBL in the second trimester in the Taiwanese population was investigated, and a linear relationship with gestational age was noted. The NBL increased with advancing gestational age (NBL in cm=0.0264×gestational age in weeks –0.042 (R2=0.2416). The median of the biparietal diameter/nasal bone length ratio had a stable value which tended to change minimally between 15 and 22 weeks of gestation. Chromosomally normal fetuses had statistically longer nasal bones than fetuses with Down syndrome (p=0.014). Conclusion: We present a reference range for 3D ultrasound measurement of the fetal NBL. A short nasal bone at 15 to 22 weeks is associated with a high risk of trisomy 21.http://www.sciencedirect.com/science/article/pii/S1028455912001209fetal nasal bone lengthultrasonography |
| spellingShingle | Pei-Yin Yang Joung-Liang Wu Guang-Perng Yeh Charles Tsung-Che Hsieh Three-dimensional ultrasonography measurement of fetal nasal bone length during the midtrimester in Taiwanese women Taiwanese Journal of Obstetrics & Gynecology fetal nasal bone length ultrasonography |
| title | Three-dimensional ultrasonography measurement of fetal nasal bone length during the midtrimester in Taiwanese women |
| title_full | Three-dimensional ultrasonography measurement of fetal nasal bone length during the midtrimester in Taiwanese women |
| title_fullStr | Three-dimensional ultrasonography measurement of fetal nasal bone length during the midtrimester in Taiwanese women |
| title_full_unstemmed | Three-dimensional ultrasonography measurement of fetal nasal bone length during the midtrimester in Taiwanese women |
| title_short | Three-dimensional ultrasonography measurement of fetal nasal bone length during the midtrimester in Taiwanese women |
| title_sort | three dimensional ultrasonography measurement of fetal nasal bone length during the midtrimester in taiwanese women |
| topic | fetal nasal bone length ultrasonography |
| url | http://www.sciencedirect.com/science/article/pii/S1028455912001209 |
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