Quasi-real-time range monitoring by in-beam PET: a case for 15O
Abstract A fast and reliable range monitoring method is required to take full advantage of the high linear energy transfer provided by therapeutic ion beams like carbon and oxygen while minimizing damage to healthy tissue due to range uncertainties. Quasi-real-time range monitoring using in-beam pos...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-11-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-45122-2 |
| _version_ | 1797636988407382016 |
|---|---|
| author | S. Purushothaman D. Kostyleva P. Dendooven E. Haettner H. Geissel C. Schuy U. Weber D. Boscolo T. Dickel C. Graeff C. Hornung E. Kazantseva N. Kuzminchuk-Feuerstein I. Mukha S. Pietri H. Roesch Y. K. Tanaka J. Zhao M. Durante K. Parodi C. Scheidenberger |
| author_facet | S. Purushothaman D. Kostyleva P. Dendooven E. Haettner H. Geissel C. Schuy U. Weber D. Boscolo T. Dickel C. Graeff C. Hornung E. Kazantseva N. Kuzminchuk-Feuerstein I. Mukha S. Pietri H. Roesch Y. K. Tanaka J. Zhao M. Durante K. Parodi C. Scheidenberger |
| author_sort | S. Purushothaman |
| collection | DOAJ |
| description | Abstract A fast and reliable range monitoring method is required to take full advantage of the high linear energy transfer provided by therapeutic ion beams like carbon and oxygen while minimizing damage to healthy tissue due to range uncertainties. Quasi-real-time range monitoring using in-beam positron emission tomography (PET) with therapeutic beams of positron-emitters of carbon and oxygen is a promising approach. The number of implanted ions and the time required for an unambiguous range verification are decisive factors for choosing a candidate isotope. An experimental study was performed at the FRS fragment-separator of GSI Helmholtzzentrum für Schwerionenforschung GmbH, Germany, to investigate the evolution of positron annihilation activity profiles during the implantation of $$^{14}$$ 14 O and $$^{15}$$ 15 O ion beams in a PMMA phantom. The positron activity profile was imaged by a dual-panel version of a Siemens Biograph mCT PET scanner. Results from a similar experiment using ion beams of carbon positron-emitters $$^{11}$$ 11 C and $$^{10}$$ 10 C performed at the same experimental setup were used for comparison. Owing to their shorter half-lives, the number of implanted ions required for a precise positron annihilation activity peak determination is lower for $$^{10}$$ 10 C compared to $$^{11}$$ 11 C and likewise for $$^{14}$$ 14 O compared to $$^{15}$$ 15 O, but their lower production cross-sections make it difficult to produce them at therapeutically relevant intensities. With a similar production cross-section and a 10 times shorter half-life than $$^{11}$$ 11 C, $$^{15}$$ 15 O provides a faster conclusive positron annihilation activity peak position determination for a lower number of implanted ions compared to $$^{11}$$ 11 C. A figure of merit formulation was developed for the quantitative comparison of therapy-relevant positron-emitting beams in the context of quasi-real-time beam monitoring. In conclusion, this study demonstrates that among the positron emitters of carbon and oxygen, $$^{15}$$ 15 O is the most feasible candidate for quasi-real-time range monitoring by in-beam PET that can be produced at therapeutically relevant intensities. Additionally, this study demonstrated that the in-flight production and separation method can produce beams of therapeutic quality, in terms of purity, energy, and energy spread. |
| first_indexed | 2024-03-11T12:42:55Z |
| format | Article |
| id | doaj.art-931d6deb2ac64302b837470478e5dc3f |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T12:42:55Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-931d6deb2ac64302b837470478e5dc3f2023-11-05T12:12:31ZengNature PortfolioScientific Reports2045-23222023-11-0113111710.1038/s41598-023-45122-2Quasi-real-time range monitoring by in-beam PET: a case for 15OS. Purushothaman0D. Kostyleva1P. Dendooven2E. Haettner3H. Geissel4C. Schuy5U. Weber6D. Boscolo7T. Dickel8C. Graeff9C. Hornung10E. Kazantseva11N. Kuzminchuk-Feuerstein12I. Mukha13S. Pietri14H. Roesch15Y. K. Tanaka16J. Zhao17M. Durante18K. Parodi19C. Scheidenberger20GSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHDepartment of Radiation Oncology, Particle Therapy Research Center (PARTREC), University Medical Center Groningen, University of GroningenGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHRIKEN Cluster for Pioneering Research, RIKENGSI Helmholtzzentrum für Schwerionenforschung GmbHGSI Helmholtzzentrum für Schwerionenforschung GmbHDepartment of Medical Physics, Faculty of Physics, Ludwig-Maximilians Universität MünchenGSI Helmholtzzentrum für Schwerionenforschung GmbHAbstract A fast and reliable range monitoring method is required to take full advantage of the high linear energy transfer provided by therapeutic ion beams like carbon and oxygen while minimizing damage to healthy tissue due to range uncertainties. Quasi-real-time range monitoring using in-beam positron emission tomography (PET) with therapeutic beams of positron-emitters of carbon and oxygen is a promising approach. The number of implanted ions and the time required for an unambiguous range verification are decisive factors for choosing a candidate isotope. An experimental study was performed at the FRS fragment-separator of GSI Helmholtzzentrum für Schwerionenforschung GmbH, Germany, to investigate the evolution of positron annihilation activity profiles during the implantation of $$^{14}$$ 14 O and $$^{15}$$ 15 O ion beams in a PMMA phantom. The positron activity profile was imaged by a dual-panel version of a Siemens Biograph mCT PET scanner. Results from a similar experiment using ion beams of carbon positron-emitters $$^{11}$$ 11 C and $$^{10}$$ 10 C performed at the same experimental setup were used for comparison. Owing to their shorter half-lives, the number of implanted ions required for a precise positron annihilation activity peak determination is lower for $$^{10}$$ 10 C compared to $$^{11}$$ 11 C and likewise for $$^{14}$$ 14 O compared to $$^{15}$$ 15 O, but their lower production cross-sections make it difficult to produce them at therapeutically relevant intensities. With a similar production cross-section and a 10 times shorter half-life than $$^{11}$$ 11 C, $$^{15}$$ 15 O provides a faster conclusive positron annihilation activity peak position determination for a lower number of implanted ions compared to $$^{11}$$ 11 C. A figure of merit formulation was developed for the quantitative comparison of therapy-relevant positron-emitting beams in the context of quasi-real-time beam monitoring. In conclusion, this study demonstrates that among the positron emitters of carbon and oxygen, $$^{15}$$ 15 O is the most feasible candidate for quasi-real-time range monitoring by in-beam PET that can be produced at therapeutically relevant intensities. Additionally, this study demonstrated that the in-flight production and separation method can produce beams of therapeutic quality, in terms of purity, energy, and energy spread.https://doi.org/10.1038/s41598-023-45122-2 |
| spellingShingle | S. Purushothaman D. Kostyleva P. Dendooven E. Haettner H. Geissel C. Schuy U. Weber D. Boscolo T. Dickel C. Graeff C. Hornung E. Kazantseva N. Kuzminchuk-Feuerstein I. Mukha S. Pietri H. Roesch Y. K. Tanaka J. Zhao M. Durante K. Parodi C. Scheidenberger Quasi-real-time range monitoring by in-beam PET: a case for 15O Scientific Reports |
| title | Quasi-real-time range monitoring by in-beam PET: a case for 15O |
| title_full | Quasi-real-time range monitoring by in-beam PET: a case for 15O |
| title_fullStr | Quasi-real-time range monitoring by in-beam PET: a case for 15O |
| title_full_unstemmed | Quasi-real-time range monitoring by in-beam PET: a case for 15O |
| title_short | Quasi-real-time range monitoring by in-beam PET: a case for 15O |
| title_sort | quasi real time range monitoring by in beam pet a case for 15o |
| url | https://doi.org/10.1038/s41598-023-45122-2 |
| work_keys_str_mv | AT spurushothaman quasirealtimerangemonitoringbyinbeampetacasefor15o AT dkostyleva quasirealtimerangemonitoringbyinbeampetacasefor15o AT pdendooven quasirealtimerangemonitoringbyinbeampetacasefor15o AT ehaettner quasirealtimerangemonitoringbyinbeampetacasefor15o AT hgeissel quasirealtimerangemonitoringbyinbeampetacasefor15o AT cschuy quasirealtimerangemonitoringbyinbeampetacasefor15o AT uweber quasirealtimerangemonitoringbyinbeampetacasefor15o AT dboscolo quasirealtimerangemonitoringbyinbeampetacasefor15o AT tdickel quasirealtimerangemonitoringbyinbeampetacasefor15o AT cgraeff quasirealtimerangemonitoringbyinbeampetacasefor15o AT chornung quasirealtimerangemonitoringbyinbeampetacasefor15o AT ekazantseva quasirealtimerangemonitoringbyinbeampetacasefor15o AT nkuzminchukfeuerstein quasirealtimerangemonitoringbyinbeampetacasefor15o AT imukha quasirealtimerangemonitoringbyinbeampetacasefor15o AT spietri quasirealtimerangemonitoringbyinbeampetacasefor15o AT hroesch quasirealtimerangemonitoringbyinbeampetacasefor15o AT yktanaka quasirealtimerangemonitoringbyinbeampetacasefor15o AT jzhao quasirealtimerangemonitoringbyinbeampetacasefor15o AT mdurante quasirealtimerangemonitoringbyinbeampetacasefor15o AT kparodi quasirealtimerangemonitoringbyinbeampetacasefor15o AT cscheidenberger quasirealtimerangemonitoringbyinbeampetacasefor15o |