Sphingolipids in Major Depression
Major depression is one of the most common and severe diseases affecting the world's population. However, the pathogenesis of the disease remains inadequately defined. Previously, a lack of monoaminergic neurotransmitters was the focus of pathophysiological concepts; however, recent concepts fo...
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| Format: | Article |
| Language: | English |
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Cell Physiol Biochem Press GmbH & Co KG
2015-12-01
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| Series: | Neurosignals |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/442603 |
| _version_ | 1828761129178890240 |
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| author | Peter L. Jernigan Richard S. Hoehn Heike Grassmé Michael J. Edwards Christian P Müller Johannes Kornhuber Erich Gulbins |
| author_facet | Peter L. Jernigan Richard S. Hoehn Heike Grassmé Michael J. Edwards Christian P Müller Johannes Kornhuber Erich Gulbins |
| author_sort | Peter L. Jernigan |
| collection | DOAJ |
| description | Major depression is one of the most common and severe diseases affecting the world's population. However, the pathogenesis of the disease remains inadequately defined. Previously, a lack of monoaminergic neurotransmitters was the focus of pathophysiological concepts; however, recent concepts focus on a alteration of neurogenesis in the hippocampus. This concept suggests that neurogenesis is decreased in major depression with a rarefication of neuronal networks and a lack of new, immature neurons in the hippocampus, events that may result in the clinical symptoms of major depression. However, molecular targets involved in the pathogenesis of major depression and, in particular, a reduction of neurogenesis, are largely unknown. We have recently discovered that an inhibition of the acid sphingomyelinase/ceramide system mediates the effects of tri- and tetracyclic antidepressants. Moreover, an accumulation of ceramide in the hippocampus results in depression-like symptoms. This suggests the acid sphingomyelinase/ceramide system is very important in the pathogenesis of major depression. |
| first_indexed | 2024-12-11T01:24:58Z |
| format | Article |
| id | doaj.art-931f38645d4645e0b960498f8408fe02 |
| institution | Directory Open Access Journal |
| issn | 1424-862X 1424-8638 |
| language | English |
| last_indexed | 2024-12-11T01:24:58Z |
| publishDate | 2015-12-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Neurosignals |
| spelling | doaj.art-931f38645d4645e0b960498f8408fe022022-12-22T01:25:34ZengCell Physiol Biochem Press GmbH & Co KGNeurosignals1424-862X1424-86382015-12-01231495810.1159/000442603442603Sphingolipids in Major DepressionPeter L. JerniganRichard S. HoehnHeike GrassméMichael J. EdwardsChristian P MüllerJohannes KornhuberErich GulbinsMajor depression is one of the most common and severe diseases affecting the world's population. However, the pathogenesis of the disease remains inadequately defined. Previously, a lack of monoaminergic neurotransmitters was the focus of pathophysiological concepts; however, recent concepts focus on a alteration of neurogenesis in the hippocampus. This concept suggests that neurogenesis is decreased in major depression with a rarefication of neuronal networks and a lack of new, immature neurons in the hippocampus, events that may result in the clinical symptoms of major depression. However, molecular targets involved in the pathogenesis of major depression and, in particular, a reduction of neurogenesis, are largely unknown. We have recently discovered that an inhibition of the acid sphingomyelinase/ceramide system mediates the effects of tri- and tetracyclic antidepressants. Moreover, an accumulation of ceramide in the hippocampus results in depression-like symptoms. This suggests the acid sphingomyelinase/ceramide system is very important in the pathogenesis of major depression.http://www.karger.com/Article/FullText/442603Acid sphingomyelinaseMajor depressionNeurogenesisCeramide |
| spellingShingle | Peter L. Jernigan Richard S. Hoehn Heike Grassmé Michael J. Edwards Christian P Müller Johannes Kornhuber Erich Gulbins Sphingolipids in Major Depression Neurosignals Acid sphingomyelinase Major depression Neurogenesis Ceramide |
| title | Sphingolipids in Major Depression |
| title_full | Sphingolipids in Major Depression |
| title_fullStr | Sphingolipids in Major Depression |
| title_full_unstemmed | Sphingolipids in Major Depression |
| title_short | Sphingolipids in Major Depression |
| title_sort | sphingolipids in major depression |
| topic | Acid sphingomyelinase Major depression Neurogenesis Ceramide |
| url | http://www.karger.com/Article/FullText/442603 |
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