Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients
The primary objective of this study was to compare the plasma levels of copper, selenium, and zinc between critically ill COVID-19 patients and less severe COVID-19 patients. The secondary objective was to investigate the association of these trace element levels with adverse outcomes, including the...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/15/3308 |
| _version_ | 1797586250539991040 |
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| author | Hannah Wozniak Christophe Le Terrier Steve Primmaz Noémie Suh Sébastien Lenglet Aurélien Thomas Nicolas Vuilleumier Sabrina Pagano Aude de Watteville Silvia Stringhini Idris Guessous Hervé Quintard Claudia Paula Heidegger Jérôme Pugin |
| author_facet | Hannah Wozniak Christophe Le Terrier Steve Primmaz Noémie Suh Sébastien Lenglet Aurélien Thomas Nicolas Vuilleumier Sabrina Pagano Aude de Watteville Silvia Stringhini Idris Guessous Hervé Quintard Claudia Paula Heidegger Jérôme Pugin |
| author_sort | Hannah Wozniak |
| collection | DOAJ |
| description | The primary objective of this study was to compare the plasma levels of copper, selenium, and zinc between critically ill COVID-19 patients and less severe COVID-19 patients. The secondary objective was to investigate the association of these trace element levels with adverse outcomes, including the duration of mechanical ventilation, occurrence of septic shock, and mortality in critically ill COVID-19 patients. All COVID-19 patients admitted to the ICU of the Geneva University Hospitals between 9 March 2020 and 19 May 2020 were included in the study. Plasma levels of copper, selenium and zinc were measured on admission to the ICU and compared with levels measured in COVID-19 patients hospitalized on the ward and in non-hospitalized COVID-19 patients. To analyze the association of trace elements with clinical outcomes, multivariate linear and logistic regressions were performed. Patients in the ICU had significantly lower levels of selenium and zinc and higher levels of copper compared to COVID-19 patients hospitalized on the ward and in non-hospitalized COVID-19 patients. In ICU patients, lower zinc levels tended to be associated with more septic shock and increased mortality compared to those with higher zinc levels (<i>p</i> = 0.07 for both). Having lower copper or selenium levels was associated with a longer time under mechanical ventilation (<i>p</i> = 0.01 and 0.04, respectively). These associations remained significant in multivariate analyses (<i>p</i> = 0.03 for copper and <i>p</i> = 0.04 for selenium). These data support the need for interventional studies to assess the potential benefit of zinc, copper and selenium supplementation in severe COVID-19 patients. |
| first_indexed | 2024-03-11T00:19:41Z |
| format | Article |
| id | doaj.art-93204f4e8e2b4bc6aa8cd01872febc10 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T00:19:41Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-93204f4e8e2b4bc6aa8cd01872febc102023-11-18T23:22:51ZengMDPI AGNutrients2072-66432023-07-011515330810.3390/nu15153308Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 PatientsHannah Wozniak0Christophe Le Terrier1Steve Primmaz2Noémie Suh3Sébastien Lenglet4Aurélien Thomas5Nicolas Vuilleumier6Sabrina Pagano7Aude de Watteville8Silvia Stringhini9Idris Guessous10Hervé Quintard11Claudia Paula Heidegger12Jérôme Pugin13Division of Intensive Care, Geneva University Hospitals, the Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandDivision of Intensive Care, Geneva University Hospitals, the Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandDivision of Intensive Care, Geneva University Hospitals, the Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandDivision of Intensive Care, Geneva University Hospitals, the Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandForensic Toxicology and Chemistry Unit, CURML, Lausanne University Hospital, Geneva University Hospitals, 1205 Geneva, SwitzerlandForensic Toxicology and Chemistry Unit, CURML, Lausanne University Hospital, Geneva University Hospitals, 1205 Geneva, SwitzerlandDivision of Laboratory Medicine, Diagnostics Department, Geneva University Hospitals, Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandDivision of Laboratory Medicine, Diagnostics Department, Geneva University Hospitals, Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandDivision of Intensive Care, Geneva University Hospitals, the Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, SwitzerlandUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, 1205 Geneva, SwitzerlandDivision of Intensive Care, Geneva University Hospitals, the Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandDivision of Intensive Care, Geneva University Hospitals, the Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandDivision of Intensive Care, Geneva University Hospitals, the Faculty of Medicine, University of Geneva, 1205 Geneva, SwitzerlandThe primary objective of this study was to compare the plasma levels of copper, selenium, and zinc between critically ill COVID-19 patients and less severe COVID-19 patients. The secondary objective was to investigate the association of these trace element levels with adverse outcomes, including the duration of mechanical ventilation, occurrence of septic shock, and mortality in critically ill COVID-19 patients. All COVID-19 patients admitted to the ICU of the Geneva University Hospitals between 9 March 2020 and 19 May 2020 were included in the study. Plasma levels of copper, selenium and zinc were measured on admission to the ICU and compared with levels measured in COVID-19 patients hospitalized on the ward and in non-hospitalized COVID-19 patients. To analyze the association of trace elements with clinical outcomes, multivariate linear and logistic regressions were performed. Patients in the ICU had significantly lower levels of selenium and zinc and higher levels of copper compared to COVID-19 patients hospitalized on the ward and in non-hospitalized COVID-19 patients. In ICU patients, lower zinc levels tended to be associated with more septic shock and increased mortality compared to those with higher zinc levels (<i>p</i> = 0.07 for both). Having lower copper or selenium levels was associated with a longer time under mechanical ventilation (<i>p</i> = 0.01 and 0.04, respectively). These associations remained significant in multivariate analyses (<i>p</i> = 0.03 for copper and <i>p</i> = 0.04 for selenium). These data support the need for interventional studies to assess the potential benefit of zinc, copper and selenium supplementation in severe COVID-19 patients.https://www.mdpi.com/2072-6643/15/15/3308COVID-19copperseleniumzincintensive care unittrace elements |
| spellingShingle | Hannah Wozniak Christophe Le Terrier Steve Primmaz Noémie Suh Sébastien Lenglet Aurélien Thomas Nicolas Vuilleumier Sabrina Pagano Aude de Watteville Silvia Stringhini Idris Guessous Hervé Quintard Claudia Paula Heidegger Jérôme Pugin Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients Nutrients COVID-19 copper selenium zinc intensive care unit trace elements |
| title | Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients |
| title_full | Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients |
| title_fullStr | Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients |
| title_full_unstemmed | Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients |
| title_short | Association of Trace Element Levels with Outcomes in Critically Ill COVID-19 Patients |
| title_sort | association of trace element levels with outcomes in critically ill covid 19 patients |
| topic | COVID-19 copper selenium zinc intensive care unit trace elements |
| url | https://www.mdpi.com/2072-6643/15/15/3308 |
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