Nutritional perspectives on sickle cell disease in Africa: a systematic review
Abstract Background Sickle cell disease (SCD) is an inherited blood disorder that predominantly affects individuals in sub-Saharan Africa. However, research that elucidates links between SCD pathophysiology and nutritional status in African patients is lacking. This systematic review aimed to assess...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Nutrition |
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| Online Access: | https://doi.org/10.1186/s40795-021-00410-w |
| _version_ | 1818610017940537344 |
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| author | Eunice Berko Nartey Jonathan Spector Seth Adu-Afarwuah Catherine L. Jones Alan Jackson Agartha Ohemeng Rajiv Shah Alice Koryo-Dabrah Amma Benneh-Akwasi Kuma Hyacinth I. Hyacinth Matilda Steiner-Asiedu |
| author_facet | Eunice Berko Nartey Jonathan Spector Seth Adu-Afarwuah Catherine L. Jones Alan Jackson Agartha Ohemeng Rajiv Shah Alice Koryo-Dabrah Amma Benneh-Akwasi Kuma Hyacinth I. Hyacinth Matilda Steiner-Asiedu |
| author_sort | Eunice Berko Nartey |
| collection | DOAJ |
| description | Abstract Background Sickle cell disease (SCD) is an inherited blood disorder that predominantly affects individuals in sub-Saharan Africa. However, research that elucidates links between SCD pathophysiology and nutritional status in African patients is lacking. This systematic review aimed to assess the landscape of studies in sub-Saharan Africa that focused on nutritional aspects of SCD, and highlights gaps in knowledge that could inform priority-setting for future research. Methods The study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Inclusion criteria comprised original, peer-reviewed research published between January 1995 and November 2020 involving individuals in Africa with any phenotypic variant of SCD and at least one nutritional status outcome. Nutritional status outcomes were defined as those that assessed dietary intakes, growth/anthropometry, or nutritional biomarkers. Databases used were Ovid Embase, Medline, Biosis and Web of Science. Results The search returned 526 articles, of which 76 were included in the final analyses. Most investigations (67%) were conducted in Nigeria. Studies were categorized into one of three main categories: descriptive studies of anthropometric characteristics (49%), descriptive studies of macro- or micronutrient status (41%), and interventional studies (11%). Findings consistently included growth impairment, especially among children and adolescents from sub-Saharan Africa. Studies assessing macro- and micronutrients generally had small sample sizes and were exploratory in nature. Only four randomized trials were identified, which measured the impact of lime juice, long-chain fatty acids supplementation, ready-to-use supplementary food (RUSF), and oral arginine on health outcomes. Conclusions The findings reveal a moderate number of descriptive studies, most with small sample sizes, that focused on various aspects of nutrition and SCD in African patients. There was a stark dearth of interventional studies that could be used to inform evidence-based changes in clinical practice. Findings from the investigations were generally consistent with data from other regional settings, describing a significant risk of growth faltering and malnutrition among individuals with SCD. There is an unmet need for clinical research to better understand the potential benefits of nutrition-related interventions for patients with SCD in sub-Saharan Africa to promote optimal growth and improve health outcomes. |
| first_indexed | 2024-12-16T15:07:45Z |
| format | Article |
| id | doaj.art-932129c6fa8340de9877234fa71f188e |
| institution | Directory Open Access Journal |
| issn | 2055-0928 |
| language | English |
| last_indexed | 2024-12-16T15:07:45Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nutrition |
| spelling | doaj.art-932129c6fa8340de9877234fa71f188e2022-12-21T22:27:04ZengBMCBMC Nutrition2055-09282021-03-017112110.1186/s40795-021-00410-wNutritional perspectives on sickle cell disease in Africa: a systematic reviewEunice Berko Nartey0Jonathan Spector1Seth Adu-Afarwuah2Catherine L. Jones3Alan Jackson4Agartha Ohemeng5Rajiv Shah6Alice Koryo-Dabrah7Amma Benneh-Akwasi Kuma8Hyacinth I. Hyacinth9Matilda Steiner-Asiedu10Department of Nutrition and Food Science, University of GhanaNovartis Institute for Tropical DiseasesDepartment of Nutrition and Food Science, University of GhanaNovartis Institute for Tropical DiseasesEmeritus Professor of Human Nutrition, Southampton General Hospital (MP 113)Department of Nutrition and Food Science, University of GhanaNovartis Global Health and Corporate ResponsibilityDepartment of Nutrition and Dietetics, University of Health and Allied SciencesDepartment of Hematology, School of Medicine and Surgery, University of GhanaAflac Cancer and Blood Disorder Center of Children’s Healthcare of Atlanta and Emory University Department of PediatricsDepartment of Nutrition and Food Science, University of GhanaAbstract Background Sickle cell disease (SCD) is an inherited blood disorder that predominantly affects individuals in sub-Saharan Africa. However, research that elucidates links between SCD pathophysiology and nutritional status in African patients is lacking. This systematic review aimed to assess the landscape of studies in sub-Saharan Africa that focused on nutritional aspects of SCD, and highlights gaps in knowledge that could inform priority-setting for future research. Methods The study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Inclusion criteria comprised original, peer-reviewed research published between January 1995 and November 2020 involving individuals in Africa with any phenotypic variant of SCD and at least one nutritional status outcome. Nutritional status outcomes were defined as those that assessed dietary intakes, growth/anthropometry, or nutritional biomarkers. Databases used were Ovid Embase, Medline, Biosis and Web of Science. Results The search returned 526 articles, of which 76 were included in the final analyses. Most investigations (67%) were conducted in Nigeria. Studies were categorized into one of three main categories: descriptive studies of anthropometric characteristics (49%), descriptive studies of macro- or micronutrient status (41%), and interventional studies (11%). Findings consistently included growth impairment, especially among children and adolescents from sub-Saharan Africa. Studies assessing macro- and micronutrients generally had small sample sizes and were exploratory in nature. Only four randomized trials were identified, which measured the impact of lime juice, long-chain fatty acids supplementation, ready-to-use supplementary food (RUSF), and oral arginine on health outcomes. Conclusions The findings reveal a moderate number of descriptive studies, most with small sample sizes, that focused on various aspects of nutrition and SCD in African patients. There was a stark dearth of interventional studies that could be used to inform evidence-based changes in clinical practice. Findings from the investigations were generally consistent with data from other regional settings, describing a significant risk of growth faltering and malnutrition among individuals with SCD. There is an unmet need for clinical research to better understand the potential benefits of nutrition-related interventions for patients with SCD in sub-Saharan Africa to promote optimal growth and improve health outcomes.https://doi.org/10.1186/s40795-021-00410-wNutritional statusMalnutritionSickle cell diseaseSickle cell anemiaSystematic review |
| spellingShingle | Eunice Berko Nartey Jonathan Spector Seth Adu-Afarwuah Catherine L. Jones Alan Jackson Agartha Ohemeng Rajiv Shah Alice Koryo-Dabrah Amma Benneh-Akwasi Kuma Hyacinth I. Hyacinth Matilda Steiner-Asiedu Nutritional perspectives on sickle cell disease in Africa: a systematic review BMC Nutrition Nutritional status Malnutrition Sickle cell disease Sickle cell anemia Systematic review |
| title | Nutritional perspectives on sickle cell disease in Africa: a systematic review |
| title_full | Nutritional perspectives on sickle cell disease in Africa: a systematic review |
| title_fullStr | Nutritional perspectives on sickle cell disease in Africa: a systematic review |
| title_full_unstemmed | Nutritional perspectives on sickle cell disease in Africa: a systematic review |
| title_short | Nutritional perspectives on sickle cell disease in Africa: a systematic review |
| title_sort | nutritional perspectives on sickle cell disease in africa a systematic review |
| topic | Nutritional status Malnutrition Sickle cell disease Sickle cell anemia Systematic review |
| url | https://doi.org/10.1186/s40795-021-00410-w |
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