Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical,...
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| author | Marlene Fabiola Escobedo-Monge Enrique Barrado Joaquín Parodi-Román María Antonieta Escobedo-Monge María Carmen Torres-Hinojal José Manuel Marugán-Miguelsanz |
| author_facet | Marlene Fabiola Escobedo-Monge Enrique Barrado Joaquín Parodi-Román María Antonieta Escobedo-Monge María Carmen Torres-Hinojal José Manuel Marugán-Miguelsanz |
| author_sort | Marlene Fabiola Escobedo-Monge |
| collection | DOAJ |
| description | Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaningfully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population. |
| first_indexed | 2024-03-10T06:18:20Z |
| format | Article |
| id | doaj.art-9321a763364748b3850e2aed66ecf0ed |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T06:18:20Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9321a763364748b3850e2aed66ecf0ed2023-11-22T19:30:47ZengMDPI AGNutrients2072-66432021-10-011310357810.3390/nu13103578Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional StudyMarlene Fabiola Escobedo-Monge0Enrique Barrado1Joaquín Parodi-Román2María Antonieta Escobedo-Monge3María Carmen Torres-Hinojal4José Manuel Marugán-Miguelsanz5Faculty of Medicine, Valladolid University, Avenida Ramón y Cajal, 7, 47005 Valladolid, SpainDepartment of Analytical Chemistry, Science Faculty, Valladolid University, Campus Miguel Delibes, Calle Paseo de Belén, 7, 47011 Valladolid, SpainScience Faculty, Cadiz University, Paseo de Carlos III, 28, 11003 Cádiz, SpainDepartment of Chemistry, Science Faculty, University of Burgos, Plaza Misael Bañuelos sn, 09001 Burgos, SpainFaculty of Medicine, Valladolid University, Avenida Ramón y Cajal, 7, 47005 Valladolid, SpainDepartment of Pediatrics of the Faculty of Medicine, Valladolid University, Avenida Ramón y Cajal, 7, 47005 Valladolid, SpainCopper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaningfully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population.https://www.mdpi.com/2072-6643/13/10/3578hypocupremiahypercupremiainflammatory responserisk of zinc deficiencyserum zinc/copper ratio |
| spellingShingle | Marlene Fabiola Escobedo-Monge Enrique Barrado Joaquín Parodi-Román María Antonieta Escobedo-Monge María Carmen Torres-Hinojal José Manuel Marugán-Miguelsanz Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study Nutrients hypocupremia hypercupremia inflammatory response risk of zinc deficiency serum zinc/copper ratio |
| title | Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study |
| title_full | Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study |
| title_fullStr | Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study |
| title_full_unstemmed | Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study |
| title_short | Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study |
| title_sort | copper and copper zn ratio in a series of children with chronic diseases a cross sectional study |
| topic | hypocupremia hypercupremia inflammatory response risk of zinc deficiency serum zinc/copper ratio |
| url | https://www.mdpi.com/2072-6643/13/10/3578 |
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