Prognostic value of pretreatment serum albumin−globulin ratio in urothelial carcinoma: A systematic review and meta-analysis
ObjectiveTo evaluate whether pretreatment albumin−globulin ratio (AGR) can be used as a biomarker for predicting the prognosis of patients with urothelial carcinoma (UC).MethodsWe systematically searched PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Google Scholar and Cochr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.992118/full |
| _version_ | 1828422256455319552 |
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| author | Zhongyou Xia Xueqin Fu Jinze Li Ji Wu Chao Niu Yulai Xu Hao Wang Xinzhu Yuan Lingtong Tang |
| author_facet | Zhongyou Xia Xueqin Fu Jinze Li Ji Wu Chao Niu Yulai Xu Hao Wang Xinzhu Yuan Lingtong Tang |
| author_sort | Zhongyou Xia |
| collection | DOAJ |
| description | ObjectiveTo evaluate whether pretreatment albumin−globulin ratio (AGR) can be used as a biomarker for predicting the prognosis of patients with urothelial carcinoma (UC).MethodsWe systematically searched PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Google Scholar and Cochrane Library; the search time was up to May 2022. Stata 16.0 was used for data processing and statistical analysis.ResultsWe identified 12 studies with 5,727 patients from 317 unique citations during the meta-analysis. Our results suggested that a low AGR before treatment was significantly associated with poor overall survival (OS) [hazard ratio (HR) = 1.99, 95% confidence interval (CI) = 1.45-2.75, P < 0.001], cancer-specific survival (CSS) [HR=2.01, 95% CI = 1.50-2.69, P < 0.001] and recurrence-free survival (RFS) [HR=1.39, 95% CI = 1.12-1.72, P = 0.002]. Furthermore, we defined different subgroups according to ethnicity, cancer type, cut-off value, sample size and stage. Similar prognostic outcomes for OS and CSS were observed in most subgroups. However, for subgroup of stage, the low pretreatment AGR only predicted the poor survival of patients with non-metastatic UC.ConclusionOur meta-analysis revealed that the AGR before treatment could be used as a predictive biomarker to indicate the prognosis of UC patients during clinical practice, especially in patients with non-metastatic UC. |
| first_indexed | 2024-12-10T15:45:54Z |
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| id | doaj.art-9321f45123a146fb89299d04c75a6dba |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T15:45:54Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9321f45123a146fb89299d04c75a6dba2022-12-22T01:42:58ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-08-011210.3389/fonc.2022.992118992118Prognostic value of pretreatment serum albumin−globulin ratio in urothelial carcinoma: A systematic review and meta-analysisZhongyou Xia0Xueqin Fu1Jinze Li2Ji Wu3Chao Niu4Yulai Xu5Hao Wang6Xinzhu Yuan7Lingtong Tang8Department of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, ChinaDepartment of Breast Surgery, Guizhou Provincial People’s Hospital, Guiyang, ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, ChinaDepartment of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, ChinaDepartment of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, ChinaDepartment of Urology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, ChinaBlood Purification Center of Department of Nephrology, Nanchong Central Hospital, The Second Clinical College, North Sichuan Medical College (University), Nanchong, ChinaDepartment of Clinical Laboratory, The People’s Hospital of Gao County, Yibin, ChinaObjectiveTo evaluate whether pretreatment albumin−globulin ratio (AGR) can be used as a biomarker for predicting the prognosis of patients with urothelial carcinoma (UC).MethodsWe systematically searched PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Google Scholar and Cochrane Library; the search time was up to May 2022. Stata 16.0 was used for data processing and statistical analysis.ResultsWe identified 12 studies with 5,727 patients from 317 unique citations during the meta-analysis. Our results suggested that a low AGR before treatment was significantly associated with poor overall survival (OS) [hazard ratio (HR) = 1.99, 95% confidence interval (CI) = 1.45-2.75, P < 0.001], cancer-specific survival (CSS) [HR=2.01, 95% CI = 1.50-2.69, P < 0.001] and recurrence-free survival (RFS) [HR=1.39, 95% CI = 1.12-1.72, P = 0.002]. Furthermore, we defined different subgroups according to ethnicity, cancer type, cut-off value, sample size and stage. Similar prognostic outcomes for OS and CSS were observed in most subgroups. However, for subgroup of stage, the low pretreatment AGR only predicted the poor survival of patients with non-metastatic UC.ConclusionOur meta-analysis revealed that the AGR before treatment could be used as a predictive biomarker to indicate the prognosis of UC patients during clinical practice, especially in patients with non-metastatic UC.https://www.frontiersin.org/articles/10.3389/fonc.2022.992118/fullbladder cancerupper tract urothelial carcinomaurothelial canceralbumin−globulin ratioprognosis |
| spellingShingle | Zhongyou Xia Xueqin Fu Jinze Li Ji Wu Chao Niu Yulai Xu Hao Wang Xinzhu Yuan Lingtong Tang Prognostic value of pretreatment serum albumin−globulin ratio in urothelial carcinoma: A systematic review and meta-analysis Frontiers in Oncology bladder cancer upper tract urothelial carcinoma urothelial cancer albumin−globulin ratio prognosis |
| title | Prognostic value of pretreatment serum albumin−globulin ratio in urothelial carcinoma: A systematic review and meta-analysis |
| title_full | Prognostic value of pretreatment serum albumin−globulin ratio in urothelial carcinoma: A systematic review and meta-analysis |
| title_fullStr | Prognostic value of pretreatment serum albumin−globulin ratio in urothelial carcinoma: A systematic review and meta-analysis |
| title_full_unstemmed | Prognostic value of pretreatment serum albumin−globulin ratio in urothelial carcinoma: A systematic review and meta-analysis |
| title_short | Prognostic value of pretreatment serum albumin−globulin ratio in urothelial carcinoma: A systematic review and meta-analysis |
| title_sort | prognostic value of pretreatment serum albumin globulin ratio in urothelial carcinoma a systematic review and meta analysis |
| topic | bladder cancer upper tract urothelial carcinoma urothelial cancer albumin−globulin ratio prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.992118/full |
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