EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism
The DHA/EPA enriched ethanolamine plasmalogens (EPA-PlsEtn) are widely present in seafood, and EPA-PlsEtn exhibits unique effects on improving cognitive functions. However, there were no reports on the alleviation of dietary EPA-PlsEtn on atherosclerosis. In the present study, supplementation with E...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464620300487 |
| _version_ | 1818723066947043328 |
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| author | Lin Ding Lingyu Zhang Haohao Shi Changhu Xue Teruyoshi Yanagita Tiantian Zhang Yuming Wang |
| author_facet | Lin Ding Lingyu Zhang Haohao Shi Changhu Xue Teruyoshi Yanagita Tiantian Zhang Yuming Wang |
| author_sort | Lin Ding |
| collection | DOAJ |
| description | The DHA/EPA enriched ethanolamine plasmalogens (EPA-PlsEtn) are widely present in seafood, and EPA-PlsEtn exhibits unique effects on improving cognitive functions. However, there were no reports on the alleviation of dietary EPA-PlsEtn on atherosclerosis. In the present study, supplementation with EPA-PlsEtn for 8 weeks dramatically reduced atherosclerotic lesions by 78% and serum LDL-c levels by 73.9% compared with model group. EPA-PlsEtn possessed lowest hepatic cholesterol levels associated with increased bile acids synthesis and excretion into feces. EPA-PlsEtn increased CYP7A1 expression through suppressing FXR activation. The increased proportion of bile acid TMCA, FXR antagonist, might contribute to the increased bile acid synthesis. In conclusion, different with EPA in form of EE or PC, EPA-PlsEtn efficiently alleviated atherosclerosis via lowering cholesterol levels by suppressing FXR expression. These findings provided new evidence and thought to explain the unique bioactivity of EPA-PlsEtn and new sight to re-understand the structure-activities relationship of DHA/EPA. |
| first_indexed | 2024-12-17T21:04:37Z |
| format | Article |
| id | doaj.art-93225ef623154f42ad85a36030cb8da0 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T21:04:37Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-93225ef623154f42ad85a36030cb8da02022-12-21T21:32:38ZengElsevierJournal of Functional Foods1756-46462020-03-0166103824EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolismLin Ding0Lingyu Zhang1Haohao Shi2Changhu Xue3Teruyoshi Yanagita4Tiantian Zhang5Yuming Wang6College of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao 266003, PR ChinaCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao 266003, PR ChinaCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao 266003, PR ChinaCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao 266003, PR China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, Shandong Province, PR ChinaLaboratory of Nutrition Biochemistry, Department of Applied Biochemistry and Food Science, Saga University, Saga, JapanCollege of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao 266003, PR China; Corresponding authors at: College of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao 266003, PR China (Y. Wang).College of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao 266003, PR China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, Shandong Province, PR China; Corresponding authors at: College of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao 266003, PR China (Y. Wang).The DHA/EPA enriched ethanolamine plasmalogens (EPA-PlsEtn) are widely present in seafood, and EPA-PlsEtn exhibits unique effects on improving cognitive functions. However, there were no reports on the alleviation of dietary EPA-PlsEtn on atherosclerosis. In the present study, supplementation with EPA-PlsEtn for 8 weeks dramatically reduced atherosclerotic lesions by 78% and serum LDL-c levels by 73.9% compared with model group. EPA-PlsEtn possessed lowest hepatic cholesterol levels associated with increased bile acids synthesis and excretion into feces. EPA-PlsEtn increased CYP7A1 expression through suppressing FXR activation. The increased proportion of bile acid TMCA, FXR antagonist, might contribute to the increased bile acid synthesis. In conclusion, different with EPA in form of EE or PC, EPA-PlsEtn efficiently alleviated atherosclerosis via lowering cholesterol levels by suppressing FXR expression. These findings provided new evidence and thought to explain the unique bioactivity of EPA-PlsEtn and new sight to re-understand the structure-activities relationship of DHA/EPA.http://www.sciencedirect.com/science/article/pii/S1756464620300487PlasmalogenHyperlipemiaAtherosclerosisCholesterol metabolismBile acid |
| spellingShingle | Lin Ding Lingyu Zhang Haohao Shi Changhu Xue Teruyoshi Yanagita Tiantian Zhang Yuming Wang EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism Journal of Functional Foods Plasmalogen Hyperlipemia Atherosclerosis Cholesterol metabolism Bile acid |
| title | EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism |
| title_full | EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism |
| title_fullStr | EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism |
| title_full_unstemmed | EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism |
| title_short | EPA-enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism |
| title_sort | epa enriched ethanolamine plasmalogen alleviates atherosclerosis via mediating bile acids metabolism |
| topic | Plasmalogen Hyperlipemia Atherosclerosis Cholesterol metabolism Bile acid |
| url | http://www.sciencedirect.com/science/article/pii/S1756464620300487 |
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