Comparison of anesthetic effects of different doses of alfentanil combined with ciprofol in elderly patients undergoing ERCP: a randomized controlled trial
Abstract Background and objects Patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) are often old and poor in physical fitness. The purpose of this study was to investigate the anesthetic effect of different doses of alfentanil combined with ciprofol in elderly patients undergo...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-023-02325-4 |
| _version_ | 1797636695384915968 |
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| author | Jun Hu Xiuxia Gu Wenhao Zhu Xiuli Zhu Fanceng Ji Yanhua Luo Ning Liu |
| author_facet | Jun Hu Xiuxia Gu Wenhao Zhu Xiuli Zhu Fanceng Ji Yanhua Luo Ning Liu |
| author_sort | Jun Hu |
| collection | DOAJ |
| description | Abstract Background and objects Patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) are often old and poor in physical fitness. The purpose of this study was to investigate the anesthetic effect of different doses of alfentanil combined with ciprofol in elderly patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). Methods In this clinical trial, 137 patients, who were candidates for ERCP were randomly divided into three groups. Group A were given 0.15 μg/kg/min of alfentanil in maintenance stage, Group B were given 0.25 μg/kg/min and Group C were given 0.35 μg/kg/min. Mean arterial pressure (MAP), heart rate (HR), oxygen saturation (SpO2) of the patients at each time point including the entry into the operation room (T0), at the beginning of surgery(T1), 10 min after surgery(T2), 20 min after surgery(T3), 30 min after surgery(T4),endoscopy withdrawal (T5) were recorded. Adverse events(including respiratory depression, body movement and hypoxemia),the dosage of ciprofol, the time of operation time and awakening were recorded. Results Compared with Group A, MAP and HR in Group B and Group C was decreased during T1-T5 (P < 0.05). Compared with group B, MAP and HR in group C was decreased during T1-T5 (P < 0.05). Compared with Group A and Group C,the number of adverse reactions of Group B was decreased(P < 0.05). There was no statistical difference in surgical time among the three groups(P > 0.05),but a statistically significant difference in recovery time (P < 0.05). Conclusion The adverse events of alfentanil 0.25μg/kg/min combined with ciprofol were low, and the anesthetic effect was the best. |
| first_indexed | 2024-03-11T12:38:50Z |
| format | Article |
| id | doaj.art-9323dfe99cd642198a90aa4c9bcf98ab |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-03-11T12:38:50Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-9323dfe99cd642198a90aa4c9bcf98ab2023-11-05T12:27:53ZengBMCBMC Anesthesiology1471-22532023-10-012311710.1186/s12871-023-02325-4Comparison of anesthetic effects of different doses of alfentanil combined with ciprofol in elderly patients undergoing ERCP: a randomized controlled trialJun Hu0Xiuxia Gu1Wenhao Zhu2Xiuli Zhu3Fanceng Ji4Yanhua Luo5Ning Liu6Department of Anesthesiology, Weifang People’s HospitalDepartment of Anesthesiology, Weifang People’s HospitalDepartment of Anesthesiology, Dongying Shengli Oilfield Central HospitalDepartment of Anesthesiology, Weifang People’s HospitalDepartment of Anesthesiology, Weifang People’s HospitalDepartment of Anesthesiology, Weifang People’s HospitalDepartment of Anesthesiology, Weifang People’s HospitalAbstract Background and objects Patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) are often old and poor in physical fitness. The purpose of this study was to investigate the anesthetic effect of different doses of alfentanil combined with ciprofol in elderly patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). Methods In this clinical trial, 137 patients, who were candidates for ERCP were randomly divided into three groups. Group A were given 0.15 μg/kg/min of alfentanil in maintenance stage, Group B were given 0.25 μg/kg/min and Group C were given 0.35 μg/kg/min. Mean arterial pressure (MAP), heart rate (HR), oxygen saturation (SpO2) of the patients at each time point including the entry into the operation room (T0), at the beginning of surgery(T1), 10 min after surgery(T2), 20 min after surgery(T3), 30 min after surgery(T4),endoscopy withdrawal (T5) were recorded. Adverse events(including respiratory depression, body movement and hypoxemia),the dosage of ciprofol, the time of operation time and awakening were recorded. Results Compared with Group A, MAP and HR in Group B and Group C was decreased during T1-T5 (P < 0.05). Compared with group B, MAP and HR in group C was decreased during T1-T5 (P < 0.05). Compared with Group A and Group C,the number of adverse reactions of Group B was decreased(P < 0.05). There was no statistical difference in surgical time among the three groups(P > 0.05),but a statistically significant difference in recovery time (P < 0.05). Conclusion The adverse events of alfentanil 0.25μg/kg/min combined with ciprofol were low, and the anesthetic effect was the best.https://doi.org/10.1186/s12871-023-02325-4Endoscopic retrograde cholangiopancreatography (ERCP)AlfentanilCiprofol |
| spellingShingle | Jun Hu Xiuxia Gu Wenhao Zhu Xiuli Zhu Fanceng Ji Yanhua Luo Ning Liu Comparison of anesthetic effects of different doses of alfentanil combined with ciprofol in elderly patients undergoing ERCP: a randomized controlled trial BMC Anesthesiology Endoscopic retrograde cholangiopancreatography (ERCP) Alfentanil Ciprofol |
| title | Comparison of anesthetic effects of different doses of alfentanil combined with ciprofol in elderly patients undergoing ERCP: a randomized controlled trial |
| title_full | Comparison of anesthetic effects of different doses of alfentanil combined with ciprofol in elderly patients undergoing ERCP: a randomized controlled trial |
| title_fullStr | Comparison of anesthetic effects of different doses of alfentanil combined with ciprofol in elderly patients undergoing ERCP: a randomized controlled trial |
| title_full_unstemmed | Comparison of anesthetic effects of different doses of alfentanil combined with ciprofol in elderly patients undergoing ERCP: a randomized controlled trial |
| title_short | Comparison of anesthetic effects of different doses of alfentanil combined with ciprofol in elderly patients undergoing ERCP: a randomized controlled trial |
| title_sort | comparison of anesthetic effects of different doses of alfentanil combined with ciprofol in elderly patients undergoing ercp a randomized controlled trial |
| topic | Endoscopic retrograde cholangiopancreatography (ERCP) Alfentanil Ciprofol |
| url | https://doi.org/10.1186/s12871-023-02325-4 |
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