Development and Characterization of Cationic Nanostructured Lipid Carriers as Drug Delivery Systems for miRNA-27a

Development and Characterization of Cationic Nanostructured Lipid Carriers as Drug Delivery Systems for miRNA-27a

Although miRNA-27a has been identified as a promising candidate for miRNA mimic therapy of obesity, its application is limited due to enzymatic degradation and low membrane permeation. To overcome these problems, we developed cationic nanostructured lipid carriers (cNLCs) using high-pressure homogen...

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Bibliographic Details
Main Authors: Amina Tucak-Smajić, Ivana Ruseska, Ilse Letofsky-Papst, Edina Vranić, Andreas Zimmer
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Pharmaceuticals
Subjects:
drug delivery system
miRNA-27a
cationic lipid nanoparticle
anti-adipogenic effect
3T3-L1 cell
cellular uptake
Online Access:https://www.mdpi.com/1424-8247/16/7/1007

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