Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study)
Abstract Background The increasing prevalence of childhood obesity has become an urgent public health problem, evidence showed that intervention for childhood obesity bring enormous health benefits. However, an effective individualized intervention strategy remains to be developed, and the accompany...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Trials |
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| Online Access: | https://doi.org/10.1186/s13063-024-08046-4 |
| _version_ | 1797247009099350016 |
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| author | Ping-ping Zhang You-xin Wang Fang-jing Shen Yun-fei Xing Jia-ying Gu Xue-ying Li Han Jin Shi-feng Jin Miao Xu Hai-jun Wang Hui Wang Li Li |
| author_facet | Ping-ping Zhang You-xin Wang Fang-jing Shen Yun-fei Xing Jia-ying Gu Xue-ying Li Han Jin Shi-feng Jin Miao Xu Hai-jun Wang Hui Wang Li Li |
| author_sort | Ping-ping Zhang |
| collection | DOAJ |
| description | Abstract Background The increasing prevalence of childhood obesity has become an urgent public health problem, evidence showed that intervention for childhood obesity bring enormous health benefits. However, an effective individualized intervention strategy remains to be developed, and the accompanying remission of related complications, such as nonalcoholic fatty liver disease (NAFLD), needs to be assessed. This study aimed to develop an m-Health-assisted lifestyle intervention program targeting overweight/obese children and assess its effectiveness on indicators of adiposity and NAFLD. Methods This is a cluster-randomized controlled trial that conducted in children with overweight/obesity in Ningbo city, Zhejiang Province, China. Students in Grade 3 (8–10 years old) were recruited from six primary schools, with three be randomized to intervention group and three to usual practice group. The intervention program will last for one academic year and consists of health education, dietary guidance, and physical activity reinforcement. This program is characterized by encouraging four stakeholders, including School, Clinic, famIly, and studENT (SCIENT), to participate in controlling childhood obesity, assisted by m-Health technology. Assessments will be conducted at baseline and 3 months, 9 months, 24 months, and 36 months after baseline. The primary outcome will be the differences between the two groups in students’ body mass index and fatty liver index at the end of the intervention (9 months after baseline). During the implementation process, quality control methods will be adopted. Discussion The program will test the effectiveness of the m-Health-assisted lifestyle intervention on children with obesity and NAFLD. The results of this study will provide evidence for establishing effective lifestyle intervention strategy aimed at childhood obesity and NAFLD and may help develop guidelines for the treatment of obesity and NAFLD in Chinese children. Trial registration Clinicaltrials.gov NCT05482191. Registered on July 2022. |
| first_indexed | 2024-04-24T19:51:52Z |
| format | Article |
| id | doaj.art-9324887467d944d89b25651c7e4ef4e5 |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-04-24T19:51:52Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-9324887467d944d89b25651c7e4ef4e52024-03-24T12:32:55ZengBMCTrials1745-62152024-03-0125111110.1186/s13063-024-08046-4Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study)Ping-ping Zhang0You-xin Wang1Fang-jing Shen2Yun-fei Xing3Jia-ying Gu4Xue-ying Li5Han Jin6Shi-feng Jin7Miao Xu8Hai-jun Wang9Hui Wang10Li Li11Ningbo Center for Healthy Lifestyle Research, The First Affiliated Hospital of Ningbo UniversityDepartment of Maternal and Child Health, School of Public Health, Peking UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo UniversityDepartment of Maternal and Child Health, School of Public Health, Peking UniversityNingbo Center for Healthy Lifestyle Research, The First Affiliated Hospital of Ningbo UniversityDepartment of Maternal and Child Health, School of Public Health, Peking UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo UniversityDepartment of Maternal and Child Health, School of Public Health, Peking UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo UniversityDepartment of Maternal and Child Health, School of Public Health, Peking UniversityDepartment of Maternal and Child Health, School of Public Health, Peking UniversityDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo UniversityAbstract Background The increasing prevalence of childhood obesity has become an urgent public health problem, evidence showed that intervention for childhood obesity bring enormous health benefits. However, an effective individualized intervention strategy remains to be developed, and the accompanying remission of related complications, such as nonalcoholic fatty liver disease (NAFLD), needs to be assessed. This study aimed to develop an m-Health-assisted lifestyle intervention program targeting overweight/obese children and assess its effectiveness on indicators of adiposity and NAFLD. Methods This is a cluster-randomized controlled trial that conducted in children with overweight/obesity in Ningbo city, Zhejiang Province, China. Students in Grade 3 (8–10 years old) were recruited from six primary schools, with three be randomized to intervention group and three to usual practice group. The intervention program will last for one academic year and consists of health education, dietary guidance, and physical activity reinforcement. This program is characterized by encouraging four stakeholders, including School, Clinic, famIly, and studENT (SCIENT), to participate in controlling childhood obesity, assisted by m-Health technology. Assessments will be conducted at baseline and 3 months, 9 months, 24 months, and 36 months after baseline. The primary outcome will be the differences between the two groups in students’ body mass index and fatty liver index at the end of the intervention (9 months after baseline). During the implementation process, quality control methods will be adopted. Discussion The program will test the effectiveness of the m-Health-assisted lifestyle intervention on children with obesity and NAFLD. The results of this study will provide evidence for establishing effective lifestyle intervention strategy aimed at childhood obesity and NAFLD and may help develop guidelines for the treatment of obesity and NAFLD in Chinese children. Trial registration Clinicaltrials.gov NCT05482191. Registered on July 2022.https://doi.org/10.1186/s13063-024-08046-4ChildrenObesityNAFLDLifestyle interventionM-Health |
| spellingShingle | Ping-ping Zhang You-xin Wang Fang-jing Shen Yun-fei Xing Jia-ying Gu Xue-ying Li Han Jin Shi-feng Jin Miao Xu Hai-jun Wang Hui Wang Li Li Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study) Trials Children Obesity NAFLD Lifestyle intervention M-Health |
| title | Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study) |
| title_full | Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study) |
| title_fullStr | Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study) |
| title_full_unstemmed | Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study) |
| title_short | Lifestyle intervention in children with obesity and nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized controlled trial in Ningbo city (the SCIENT study) |
| title_sort | lifestyle intervention in children with obesity and nonalcoholic fatty liver disease nafld study protocol for a randomized controlled trial in ningbo city the scient study |
| topic | Children Obesity NAFLD Lifestyle intervention M-Health |
| url | https://doi.org/10.1186/s13063-024-08046-4 |
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