The current therapeutic strategies in ovarian cancer treatment
Introduction: ovarian cancer is one of the most common and lethal tumor in women. This happens as a result of late-stage cancer detention and an increased chemoresistance to standard therapy. The current development in therapies to kill the cancer cells and its spread tendencies has emerged as a key...
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| Format: | Article |
| Language: | Spanish |
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Universidad de Ciencias Médicas de Guantánamo
2023-07-01
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| Series: | Revista Información Científica |
| Subjects: | |
| Online Access: | https://revinfcientifica.sld.cu/index.php/ric/article/view/4190 |
| _version_ | 1797373010552815616 |
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| author | Carmita Lemus-Valdés Alejandro Padrón-Albertus |
| author_facet | Carmita Lemus-Valdés Alejandro Padrón-Albertus |
| author_sort | Carmita Lemus-Valdés |
| collection | DOAJ |
| description | Introduction: ovarian cancer is one of the most common and lethal tumor in women. This happens as a result of late-stage cancer detention and an increased chemoresistance to standard therapy. The current development in therapies to kill the cancer cells and its spread tendencies has emerged as a key alternative to treat tumors.
Objective: to describe the current therapeutic strategies lead to confront different capabilities of tumor cells found in the ovarian cancer treatment.
Method: a search of literuture was carried out in the following databases ScienceDirect, Redalyc, Latindex, ResearchGate, PubMed, Elsevier, ClinicalTrials.gov, SpringerLink, LARVOL's CLIN, Cuban Public Registry of Clinical Trials, from January to April 2023. A total of 50 text concerning ovarian cancer subject and alternative for treatment were selected.
Development: the driving factors that promoted the use of ovarian cancer therapies were pointed out. The current therapeutic targets used in the treatment of this neoplasia were described, as well as the use of multiple approved drugs or in process of approval, including the synergistic drug combinations.
Final considerations: there are a lot of options currently being implemented in ovarian cancer treatment. Despite clinical efficacy of targeted therapy, it´s presented still restricted to specific molecular subtypes and none of the assays illustrated survival benefit in general; the results obtained in the process of drugs development specifically targeting genome instability and sustained angiogenesis have been remarkable. |
| first_indexed | 2024-03-08T18:44:09Z |
| format | Article |
| id | doaj.art-9327c606183d4320b6fd99bb0e5ae6c6 |
| institution | Directory Open Access Journal |
| issn | 1028-9933 |
| language | Spanish |
| last_indexed | 2024-03-08T18:44:09Z |
| publishDate | 2023-07-01 |
| publisher | Universidad de Ciencias Médicas de Guantánamo |
| record_format | Article |
| series | Revista Información Científica |
| spelling | doaj.art-9327c606183d4320b6fd99bb0e5ae6c62023-12-29T01:40:35ZspaUniversidad de Ciencias Médicas de GuantánamoRevista Información Científica1028-99332023-07-01102010.5281/zenodo.81484082455The current therapeutic strategies in ovarian cancer treatmentCarmita Lemus-Valdés0Alejandro Padrón-Albertus1Universidad de La Habana. Facultad de BiologíaUniversidad de La Habana. Facultad de BiologíaIntroduction: ovarian cancer is one of the most common and lethal tumor in women. This happens as a result of late-stage cancer detention and an increased chemoresistance to standard therapy. The current development in therapies to kill the cancer cells and its spread tendencies has emerged as a key alternative to treat tumors. Objective: to describe the current therapeutic strategies lead to confront different capabilities of tumor cells found in the ovarian cancer treatment. Method: a search of literuture was carried out in the following databases ScienceDirect, Redalyc, Latindex, ResearchGate, PubMed, Elsevier, ClinicalTrials.gov, SpringerLink, LARVOL's CLIN, Cuban Public Registry of Clinical Trials, from January to April 2023. A total of 50 text concerning ovarian cancer subject and alternative for treatment were selected. Development: the driving factors that promoted the use of ovarian cancer therapies were pointed out. The current therapeutic targets used in the treatment of this neoplasia were described, as well as the use of multiple approved drugs or in process of approval, including the synergistic drug combinations. Final considerations: there are a lot of options currently being implemented in ovarian cancer treatment. Despite clinical efficacy of targeted therapy, it´s presented still restricted to specific molecular subtypes and none of the assays illustrated survival benefit in general; the results obtained in the process of drugs development specifically targeting genome instability and sustained angiogenesis have been remarkable.https://revinfcientifica.sld.cu/index.php/ric/article/view/4190cáncer de ovariocáncer epitelial de ovariofármaco antitumoralquimiorresistenciaterapia molecular dirigida |
| spellingShingle | Carmita Lemus-Valdés Alejandro Padrón-Albertus The current therapeutic strategies in ovarian cancer treatment Revista Información Científica cáncer de ovario cáncer epitelial de ovario fármaco antitumoral quimiorresistencia terapia molecular dirigida |
| title | The current therapeutic strategies in ovarian cancer treatment |
| title_full | The current therapeutic strategies in ovarian cancer treatment |
| title_fullStr | The current therapeutic strategies in ovarian cancer treatment |
| title_full_unstemmed | The current therapeutic strategies in ovarian cancer treatment |
| title_short | The current therapeutic strategies in ovarian cancer treatment |
| title_sort | current therapeutic strategies in ovarian cancer treatment |
| topic | cáncer de ovario cáncer epitelial de ovario fármaco antitumoral quimiorresistencia terapia molecular dirigida |
| url | https://revinfcientifica.sld.cu/index.php/ric/article/view/4190 |
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